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Conference Paper: Physiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids

TitlePhysiological β-catenin signaling regulates pluripotency genes in cancer microcell hybrids
Authors
Cheng, YCheung, AKLKo, JMYPhoon, YPLung, ML
Issue Date2012
PublisherAmerican Association for Cancer Research.
Citation
The 103rd Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012. How to Cite?
AbstractBoth β-catenin signaling and Nanog were previously reported to be involved in cell fusion-mediated somatic cell reprogramming. It remains unclear as to how the β-catenin signaling pathway is initiated and whether this pathway may directly control the expression of core stem cell factors such as Nanog and Oct4. Since β-catenin signaling is a predominating force for the regulation of cellular fate and basic levels of this signaling are needed for somatic cell reprogramming, we speculate that transfer of a single copy of chromosome 3, where β-catenin maps and is controlled by its natural regulators, into somatic cancer cells may appropriately induce this pathway and switch on the expression of endogenous pluripotency genes in recipient cells. We previously generated …
DescriptionPoster Session 15 - Markers of Cancer Stem and iPS Cells: abstract no. 420
Persistent Identifierhttp://hdl.handle.net/10722/149233

 

DC FieldValueLanguage
dc.contributor.authorCheng, Yen_US
dc.contributor.authorCheung, AKLen_US
dc.contributor.authorKo, JMYen_US
dc.contributor.authorPhoon, YPen_US
dc.contributor.authorLung, MLen_US
dc.date.accessioned2012-06-22T06:31:39Z-
dc.date.available2012-06-22T06:31:39Z-
dc.date.issued2012en_US
dc.identifier.citationThe 103rd Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012.en_US
dc.identifier.urihttp://hdl.handle.net/10722/149233-
dc.descriptionPoster Session 15 - Markers of Cancer Stem and iPS Cells: abstract no. 420-
dc.description.abstractBoth β-catenin signaling and Nanog were previously reported to be involved in cell fusion-mediated somatic cell reprogramming. It remains unclear as to how the β-catenin signaling pathway is initiated and whether this pathway may directly control the expression of core stem cell factors such as Nanog and Oct4. Since β-catenin signaling is a predominating force for the regulation of cellular fate and basic levels of this signaling are needed for somatic cell reprogramming, we speculate that transfer of a single copy of chromosome 3, where β-catenin maps and is controlled by its natural regulators, into somatic cancer cells may appropriately induce this pathway and switch on the expression of endogenous pluripotency genes in recipient cells. We previously generated …-
dc.languageengen_US
dc.publisherAmerican Association for Cancer Research.en_US
dc.relation.ispartofAnnual Meeting of the American Association for Cancer Research, AACR 2012en_US
dc.titlePhysiological β-catenin signaling regulates pluripotency genes in cancer microcell hybridsen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheng, Y: yuecheng@hku.hken_US
dc.identifier.emailCheung, AKL: arthurhk@hku.hken_US
dc.identifier.emailKo, JMY: joko@hku.hken_US
dc.identifier.emailPhoon, YP: yeepeng@hku.hken_US
dc.identifier.emailLung, ML: mlilung@hku.hk-
dc.identifier.authorityCheng, Y=rp01320en_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros199893en_US
dc.publisher.placeUnited States-
dc.description.otherThe 103rd Annual Meeting of the American Association for Cancer Research (AACR 2012), Chicago, IL., 31 March-4 April 2012.-

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