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Article: Chromosomal distribution of the human cardiovascular transcriptome

TitleChromosomal distribution of the human cardiovascular transcriptome
Authors
KeywordsChromosome mapping
Gene expression profiling
Genomics
Transcript expression analysis
Issue Date2003
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygeno
Citation
Genomics, 2003, v. 81 n. 5, p. 519-524 How to Cite?
AbstractOn the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacterized cardiovascular expressed-sequence tags (cvESTs) to 5-Mb chromosomal 'windows' on the basis of publicly available sequence mapping data. On a whole-genome level (36,617 genes), chromosome 17 (19.2% in fetal, 16.5% in adult) contained the highest proportion of cvESTs, whereas chromosome Y (2.0% in fetal and adult) contained the lowest. In total, 50 of the 639 windows contained a significantly higher proportion of cvESTs (P < 0.003) compared with the genome-wide cvEST gene density, particularly on gene-dense chromosomes (that is, 17, 19, 22) as opposed to gene-rich chromosomes (for example, 1, 2, 11). This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome. © 2003 Elsevier Science (USA). All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/148328
ISSN
2023 Impact Factor: 3.4
2023 SCImago Journal Rankings: 0.850
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorBarrans, JDen_US
dc.contributor.authorIp, Jen_US
dc.contributor.authorLam, CWen_US
dc.contributor.authorHwang, ILen_US
dc.contributor.authorDzau, VJen_US
dc.contributor.authorLiew, CCen_US
dc.date.accessioned2012-05-29T06:12:15Z-
dc.date.available2012-05-29T06:12:15Z-
dc.date.issued2003en_US
dc.identifier.citationGenomics, 2003, v. 81 n. 5, p. 519-524en_US
dc.identifier.issn0888-7543en_US
dc.identifier.urihttp://hdl.handle.net/10722/148328-
dc.description.abstractOn the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacterized cardiovascular expressed-sequence tags (cvESTs) to 5-Mb chromosomal 'windows' on the basis of publicly available sequence mapping data. On a whole-genome level (36,617 genes), chromosome 17 (19.2% in fetal, 16.5% in adult) contained the highest proportion of cvESTs, whereas chromosome Y (2.0% in fetal and adult) contained the lowest. In total, 50 of the 639 windows contained a significantly higher proportion of cvESTs (P < 0.003) compared with the genome-wide cvEST gene density, particularly on gene-dense chromosomes (that is, 17, 19, 22) as opposed to gene-rich chromosomes (for example, 1, 2, 11). This report provides insight into a possible role for complex tissue-specific gene regulation in the human genome. © 2003 Elsevier Science (USA). All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygenoen_US
dc.relation.ispartofGenomicsen_US
dc.subjectChromosome mapping-
dc.subjectGene expression profiling-
dc.subjectGenomics-
dc.subjectTranscript expression analysis-
dc.subject.meshCardiovascular System - Metabolismen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshDna, Complementaryen_US
dc.subject.meshDatabases, Nucleic Aciden_US
dc.subject.meshExpressed Sequence Tagsen_US
dc.subject.meshGene Expression Profilingen_US
dc.subject.meshHumansen_US
dc.titleChromosomal distribution of the human cardiovascular transcriptomeen_US
dc.typeArticleen_US
dc.identifier.emailLam, CW:ching-wanlam@pathology.hku.hken_US
dc.identifier.authorityLam, CW=rp00260en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/S0888-7543(03)00008-9en_US
dc.identifier.pmid12706110-
dc.identifier.scopuseid_2-s2.0-0037405387en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037405387&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue5en_US
dc.identifier.spage519en_US
dc.identifier.epage524en_US
dc.identifier.isiWOS:000182464800008-
dc.publisher.placeUnited Statesen_US
dc.identifier.issnl0888-7543-

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