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Article: SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese

TitleSNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese
Authors
Fan, YHSong, YQChan, DTakahashi, YIkegawa, SMatsumoto, MKou, ICheah, KSESham, PCheung, KMCLuk, KDK
KeywordsAdolescent idiopathic scoliosis
Replication study
rs11190870
Southern Chinese
Issue Date2012
PublisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10038/index.htm
Citation
Journal Of Human Genetics, 2012, v. 57 n. 4, p. 244-246 How to Cite?
DOI: http://dx.doi.org/10.1038/jhg.2012.11
AbstractA study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10 -10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS. © 2012 The Japan Society of Human Genetics All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/147662
ISSN
1434-5161
2021 Impact Factor: 3.755
2020 SCImago Journal Rankings: 1.055
ISI Accession Number ID
WOS:000303416800005
Funding AgencyGrant Number
Seed Funding Programme for Basic Research
University of Hong Kong (HKU)
HKU Strategic Research Themes on Genomics and on Development Reproduction
AOSPINE
Tam Sai Kit Endowment Fund
Funding Information:

This study was supported by grants from the Seed Funding Programme for Basic Research, the University of Hong Kong (HKU), the HKU Strategic Research Themes on Genomics and on Development & Reproduction, AOSPINE and the Tam Sai Kit Endowment Fund. We thank Josephine Lam for technical help.

References
References in Scopus
Grants
Developmental genomics and skeletal research

 

DC FieldValueLanguage
dc.contributor.authorFan, YHen_HK
dc.contributor.authorSong, YQen_HK
dc.contributor.authorChan, Den_HK
dc.contributor.authorTakahashi, Yen_HK
dc.contributor.authorIkegawa, Sen_HK
dc.contributor.authorMatsumoto, Men_HK
dc.contributor.authorKou, Ien_HK
dc.contributor.authorCheah, KSEen_HK
dc.contributor.authorSham, Pen_HK
dc.contributor.authorCheung, KMCen_HK
dc.contributor.authorLuk, KDKen_HK
dc.date.accessioned2012-05-29T06:05:20Z-
dc.date.available2012-05-29T06:05:20Z-
dc.date.issued2012en_HK
dc.identifier.citationJournal Of Human Genetics, 2012, v. 57 n. 4, p. 244-246en_HK
dc.identifier.issn1434-5161en_HK
dc.identifier.urihttp://hdl.handle.net/10722/147662-
dc.description.abstractA study was conducted to validate the most significant single nucleotide polymorphism (SNP) from a genome-wide association study of Japanese adolescent idiopathic scoliosis (AIS) patients in an independent southern Chinese population. In total, 300 AIS patients fulfilled the clinical criteria and 788 controls with MRI scans of the spine were included in the replication study. We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population. The results suggest that SNP rs11190870 is significantly associated with AIS (P=9.1 × 10 -10; odds ratio1.85; 95% confidence interval=1.52-2.25). The results of this study confirm that SNP rs11190870 is associated with AIS. © 2012 The Japan Society of Human Genetics All rights reserved.en_HK
dc.languageengen_US
dc.publisherSpringer Japan. The Journal's web site is located at http://link.springer.de/link/service/journals/10038/index.htmen_HK
dc.relation.ispartofJournal of Human Geneticsen_HK
dc.subjectAdolescent idiopathic scoliosisen_HK
dc.subjectReplication studyen_HK
dc.subjectrs11190870en_HK
dc.subjectSouthern Chineseen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAsian Continental Ancestry Group - geneticsen_HK
dc.subject.meshCase-Control Studiesen_HK
dc.subject.meshChilden_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGene Frequencyen_HK
dc.subject.meshGenetic Predisposition to Diseaseen_HK
dc.subject.meshGenetics, Populationen_HK
dc.subject.meshGenome-Wide Association Studyen_HK
dc.subject.meshHomeodomain Proteins - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMagnetic Resonance Imagingen_HK
dc.subject.meshMaleen_HK
dc.subject.meshOdds Ratioen_HK
dc.subject.meshPolymorphism, Single Nucleotideen_HK
dc.subject.meshScoliosis - geneticsen_HK
dc.subject.meshSex Factorsen_HK
dc.subject.meshTranscription Factors - geneticsen_HK
dc.subject.meshYoung Adulten_HK
dc.titleSNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chineseen_HK
dc.typeArticleen_HK
dc.identifier.emailChan, D: chand@hku.hken_HK
dc.identifier.emailCheah, KSE: hrmbdkc@hku.hken_HK
dc.identifier.emailSham, P: pcsham@hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK: hcm21000@hku.hken_HK
dc.identifier.authorityChan, D=rp00540en_HK
dc.identifier.authorityCheah, KSE=rp00342en_HK
dc.identifier.authoritySham, P=rp00459en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/jhg.2012.11en_HK
dc.identifier.pmid22301463-
dc.identifier.scopuseid_2-s2.0-84860300759en_HK
dc.identifier.hkuros200628-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84860300759&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume57en_HK
dc.identifier.issue4en_HK
dc.identifier.spage244en_HK
dc.identifier.epage246en_HK
dc.identifier.isiWOS:000303416800005-
dc.publisher.placeJapanen_HK
dc.relation.projectDevelopmental genomics and skeletal research-
dc.identifier.scopusauthoridFan, YH=37461378000en_HK
dc.identifier.scopusauthoridSong, YQ=47761560700en_HK
dc.identifier.scopusauthoridChan, D=7402216545en_HK
dc.identifier.scopusauthoridTakahashi, Y=37108651300en_HK
dc.identifier.scopusauthoridIkegawa, S=7102780383en_HK
dc.identifier.scopusauthoridMatsumoto, M=35429991100en_HK
dc.identifier.scopusauthoridKou, I=22985136000en_HK
dc.identifier.scopusauthoridCheah, KSE=35387746200en_HK
dc.identifier.scopusauthoridSham, P=34573429300en_HK
dc.identifier.scopusauthoridCheung, KMC=7402406754en_HK
dc.identifier.scopusauthoridLuk, KDK=7201921573en_HK
dc.identifier.issnl1434-5161-

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