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- PMID: 21944585
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Article: Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors
Title | Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors |
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Authors | |
Keywords | Association study Familial aggregation Genetics Lumbar disk degeneration Twin studies |
Issue Date | 2011 |
Publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cort |
Citation | Orthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 479-486 How to Cite? |
Abstract | Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years. © 2011 Elsevier Inc. |
Persistent Identifier | http://hdl.handle.net/10722/147641 |
ISSN | 2023 Impact Factor: 1.4 2023 SCImago Journal Rankings: 0.683 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Kao, PYP | en_HK |
dc.contributor.author | Chan, D | en_HK |
dc.contributor.author | Samartzis, D | en_HK |
dc.contributor.author | Sham, PC | en_HK |
dc.contributor.author | Song, YQ | en_HK |
dc.date.accessioned | 2012-05-29T06:05:10Z | - |
dc.date.available | 2012-05-29T06:05:10Z | - |
dc.date.issued | 2011 | en_HK |
dc.identifier.citation | Orthopedic Clinics Of North America, 2011, v. 42 n. 4, p. 479-486 | en_HK |
dc.identifier.issn | 0030-5898 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/147641 | - |
dc.description.abstract | Lumbar disk degeneration (LDD) is a common musculoskeletal condition. Genetic risk factors have been suggested to play a major role in its cause. This article reviews the main research strategies that have been used to study the genetics of LDD, and the genes that thus far have been identified to influence susceptibility to LDD. With the rapid progress in genomic technologies, further advances in the genetics of LDD are expected in the next few years. © 2011 Elsevier Inc. | en_HK |
dc.language | eng | en_US |
dc.publisher | WB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/cort | en_HK |
dc.relation.ispartof | Orthopedic Clinics of North America | en_HK |
dc.rights | NOTICE: this is the author’s version of a work that was accepted for publication in Orthopedic Clinics of North America. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Orthopedic Clinics of North America, 2011, v. 42 n. 4, p. 479-486. DOI: 10.1016/j.ocl.2011.07.011 | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Association study | en_HK |
dc.subject | Familial aggregation | en_HK |
dc.subject | Genetics | en_HK |
dc.subject | Lumbar disk degeneration | en_HK |
dc.subject | Twin studies | en_HK |
dc.subject.mesh | Age Factors | en_US |
dc.subject.mesh | Cross-Sectional Studies | en_US |
dc.subject.mesh | Disease Progression | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Genetic Predisposition To Disease - Epidemiology | en_US |
dc.subject.mesh | Genetic Testing | en_US |
dc.subject.mesh | Genomics | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Intervertebral Disc Degeneration - Genetics - Physiopathology | en_US |
dc.subject.mesh | Low Back Pain - Genetics - Physiopathology | en_US |
dc.subject.mesh | Lumbar Vertebrae | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Prognosis | en_US |
dc.subject.mesh | Risk Factors | en_US |
dc.subject.mesh | Severity Of Illness Index | en_US |
dc.title | Genetics of Lumbar Disk Degeneration: Technology, Study Designs, and Risk Factors | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Chan, D: chand@hku.hk | en_HK |
dc.identifier.email | Samartzis, D: dspine@hku.hk | en_HK |
dc.identifier.email | Sham, PC: pcsham@hku.hk | en_HK |
dc.identifier.email | Song, YQ: songy@hku.hk | en_HK |
dc.identifier.authority | Chan, D=rp00540 | en_HK |
dc.identifier.authority | Samartzis, D=rp01430 | en_HK |
dc.identifier.authority | Sham, PC=rp00459 | en_HK |
dc.identifier.authority | Song, YQ=rp00488 | en_HK |
dc.description.nature | postprint | en_US |
dc.identifier.doi | 10.1016/j.ocl.2011.07.011 | en_HK |
dc.identifier.pmid | 21944585 | - |
dc.identifier.scopus | eid_2-s2.0-80053184385 | en_HK |
dc.identifier.hkuros | 205924 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80053184385&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 42 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 479 | en_HK |
dc.identifier.epage | 486 | en_HK |
dc.identifier.isi | WOS:000208681100004 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | YuPing Kao, P=51664291000 | en_HK |
dc.identifier.scopusauthorid | Chan, D=7402216545 | en_HK |
dc.identifier.scopusauthorid | Samartzis, D=34572771100 | en_HK |
dc.identifier.scopusauthorid | Sham, PC=34573429300 | en_HK |
dc.identifier.scopusauthorid | Song, YQ=7404921212 | en_HK |
dc.identifier.issnl | 0030-5898 | - |