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Conference Paper: Importance of zinc-binding domain of matrix metalloproteinase 19 (MMP19) in tumor suppression and anti-angiogenesis of nasopharyngeal carcinoma

TitleImportance of zinc-binding domain of matrix metalloproteinase 19 (MMP19) in tumor suppression and anti-angiogenesis of nasopharyngeal carcinoma
Authors
Chan, KCKo, JMYLung, HLSedlacek, RLung, ML
Issue Date2010
PublisherAmerican Association for Cancer Research.
Citation
The 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010. How to Cite?
AbstractBACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases consisting of more than 20 enzymes. MMP19 shares the typical MMP structural domains. It degrades various ECM components including collagen type IV, nidogen-1, fibronectin, tenascin-C isoform, aggrecan, and laminin-5-gamma-2-chain. In our previous studies, MMP19 was identified as a candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC). It was down-regulated in NPC cell lines and NPC biopsies, when compared to an immortalized normal nasopharyngeal epithelial cell line and corresponding non-tumor nasopharyngeal tissues. Transfection of wild-type (WT) MMP19 into the ...
DescriptionPoster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3069
Persistent Identifierhttp://hdl.handle.net/10722/126825

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorKo, JMYen_HK
dc.contributor.authorLung, HLen_HK
dc.contributor.authorSedlacek, Ren_HK
dc.contributor.authorLung, MLen_HK
dc.date.accessioned2010-10-31T12:50:45Z-
dc.date.available2010-10-31T12:50:45Z-
dc.date.issued2010en_HK
dc.identifier.citationThe 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126825-
dc.descriptionPoster Session 5 - Novel Tumor Suppressor Genes 1: abstract no. 3069-
dc.description.abstractBACKGROUND AND AIMS: Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases consisting of more than 20 enzymes. MMP19 shares the typical MMP structural domains. It degrades various ECM components including collagen type IV, nidogen-1, fibronectin, tenascin-C isoform, aggrecan, and laminin-5-gamma-2-chain. In our previous studies, MMP19 was identified as a candidate tumor suppressor gene (TSG) in nasopharyngeal carcinoma (NPC). It was down-regulated in NPC cell lines and NPC biopsies, when compared to an immortalized normal nasopharyngeal epithelial cell line and corresponding non-tumor nasopharyngeal tissues. Transfection of wild-type (WT) MMP19 into the ...-
dc.languageengen_HK
dc.publisherAmerican Association for Cancer Research.-
dc.relation.ispartofAnnual Meeting of the American Association for Cancer Research, AACR 2010-
dc.titleImportance of zinc-binding domain of matrix metalloproteinase 19 (MMP19) in tumor suppression and anti-angiogenesis of nasopharyngeal carcinomaen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KC: mentoscan@yahoo.com.hken_HK
dc.identifier.emailKo, JMY: joko@HKUCC-COM.hku.hken_HK
dc.identifier.emailLung, HL: hllung2@hku.hken_HK
dc.identifier.emailLung, ML: mlilung@hku.hken_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros170955en_HK
dc.publisher.placeUnited States-
dc.description.otherThe 101st Annual Meeting of the American Association for Cancer Research (AACR 2010), Washington, DC., 17-21 April 2010.-

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