File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Determinants of daytime blood pressure in relation to obstructive sleep apnea in men

TitleDeterminants of daytime blood pressure in relation to obstructive sleep apnea in men
Authors
KeywordsConventional risk factors
Daytime blood pressure
Obstructive sleep apnea
Sympathetic activity
Issue Date2009
PublisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/
Citation
Lung, 2009, v. 187 n. 5, p. 291-298 How to Cite?
AbstractThis study investigated the roles of different potential pathophysiological mechanisms in the determination of blood pressure in relation to obstructive sleep apnea. The study was designed as a cross-sectional study. Consecutive healthy male subjects who were to undergo polysomnography were recruited. Demographic and anthropometric data were collected. Blood pressure measurements were taken in the evening before sleep and the next morning on waking. Overnight urinary samples for catecholamines and fasting blood for cortisol, insulin, glucose, and lipids were taken. Ninety-four men were analyzed, with a mean age of 43.7 ± 9.3 years and mean apnea-hypopnea index (AHI) of 27.5 ± 26.2 events/h. Sixty-nine patients (73%) had obstructive sleep apnea (AHI ≥5). Urinary catecholamines were positively correlated with severity of sleep apnea, independent of obesity. Blood pressure measurements correlated with age, obesity, severity of sleep apnea, and urinary catecholamines. Regression analysis showed that sleep indices and urinary catecholamines were independent determinants of morning systolic and diastolic blood pressure, respectively, while total cholesterol and waist circumference were respective additional factors. Urinary catecholamines and waist circumference were determinants of evening blood pressure, with morning cortisol being an additional determinant for diastolic blood pressure. Obstructive sleep apnea and related sympathetic activity contributed significantly to the determination of daytime blood pressure in overweight middle-aged men without overt cardiometabolic diseases, and other contributing factors include abdominal obesity, total cholesterol, and cortisol levels. © 2009 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/126483
ISSN
2023 Impact Factor: 4.6
2023 SCImago Journal Rankings: 1.293
ISI Accession Number ID
Funding AgencyGrant Number
Lee Wing Tat Cardiorespiratory Research Fund, Department of Medicine, University of Hong Kong
Funding Information:

This study was supported by the Lee Wing Tat Cardiorespiratory Research Fund, Department of Medicine, University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLam, JCMen_HK
dc.contributor.authorYan, CSWen_HK
dc.contributor.authorLai, AYKen_HK
dc.contributor.authorTam, Sen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorLam, Ben_HK
dc.contributor.authorIp, MSMen_HK
dc.date.accessioned2010-10-31T12:31:17Z-
dc.date.available2010-10-31T12:31:17Z-
dc.date.issued2009en_HK
dc.identifier.citationLung, 2009, v. 187 n. 5, p. 291-298en_HK
dc.identifier.issn0341-2040en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126483-
dc.description.abstractThis study investigated the roles of different potential pathophysiological mechanisms in the determination of blood pressure in relation to obstructive sleep apnea. The study was designed as a cross-sectional study. Consecutive healthy male subjects who were to undergo polysomnography were recruited. Demographic and anthropometric data were collected. Blood pressure measurements were taken in the evening before sleep and the next morning on waking. Overnight urinary samples for catecholamines and fasting blood for cortisol, insulin, glucose, and lipids were taken. Ninety-four men were analyzed, with a mean age of 43.7 ± 9.3 years and mean apnea-hypopnea index (AHI) of 27.5 ± 26.2 events/h. Sixty-nine patients (73%) had obstructive sleep apnea (AHI ≥5). Urinary catecholamines were positively correlated with severity of sleep apnea, independent of obesity. Blood pressure measurements correlated with age, obesity, severity of sleep apnea, and urinary catecholamines. Regression analysis showed that sleep indices and urinary catecholamines were independent determinants of morning systolic and diastolic blood pressure, respectively, while total cholesterol and waist circumference were respective additional factors. Urinary catecholamines and waist circumference were determinants of evening blood pressure, with morning cortisol being an additional determinant for diastolic blood pressure. Obstructive sleep apnea and related sympathetic activity contributed significantly to the determination of daytime blood pressure in overweight middle-aged men without overt cardiometabolic diseases, and other contributing factors include abdominal obesity, total cholesterol, and cortisol levels. © 2009 Springer Science+Business Media, LLC.en_HK
dc.languageengen_HK
dc.publisherSpringer New York LLC. The Journal's web site is located at http://link.springer.de/link/service/journals/00408/en_HK
dc.relation.ispartofLungen_HK
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectConventional risk factorsen_HK
dc.subjectDaytime blood pressureen_HK
dc.subjectObstructive sleep apneaen_HK
dc.subjectSympathetic activityen_HK
dc.subject.meshAdult-
dc.subject.meshBlood Pressure-
dc.subject.meshCircadian Rhythm-
dc.subject.meshHypertension - etiology - metabolism - physiopathology-
dc.subject.meshSleep Apnea, Obstructive - complications - metabolism - physiopathology-
dc.titleDeterminants of daytime blood pressure in relation to obstructive sleep apnea in menen_HK
dc.typeArticleen_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.emailIp, MSM: msmip@hku.hken_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00408-009-9161-7en_HK
dc.identifier.pmid19653037-
dc.identifier.scopuseid_2-s2.0-70349240253en_HK
dc.identifier.hkuros174581en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70349240253&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume187en_HK
dc.identifier.issue5en_HK
dc.identifier.spage291en_HK
dc.identifier.epage298en_HK
dc.identifier.isiWOS:000269880700004-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, JCM=25923453500en_HK
dc.identifier.scopusauthoridYan, CSW=35106566600en_HK
dc.identifier.scopusauthoridLai, AYK=25641477800en_HK
dc.identifier.scopusauthoridTam, S=7202037323en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridLam, B=9246012800en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.citeulike5400216-
dc.identifier.issnl0341-2040-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats