File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Prevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: A study of a large blood donor population

TitlePrevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: A study of a large blood donor population
Authors
Issue Date2010
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
Citation
Gut, 2010, v. 59 n. 10, p. 1389-1393 How to Cite?
AbstractBackground and aims: The aim of the present study was to determine the population prevalence of occult hepatitis B (OHB) infection and its clinical profile in a highly endemic area of chronic hepatitis B virus disease. Methods: OHB was first identified by individual sample testing for hepatitis B surface antigen (HBsAg) followed by nucleic acid testing (NAT) and vice versa for 3044 (cohort 1, stored sera from donation within 1 year) and 9990 (cohort 2, prospective study) blood donors, respectively. OHB was confirmed meticulously by ≥2 out of 3 tests with detectable hepatitis B virus (HBV) DNA using a sensitive standardised assay. Detailed serology and viral load in the serum and liver were studied. Results: The prevalence of OHB was 0.13% (4/3044) and 0.11% (11/9967) for cohort 1 and 2, respectively. In cohort 2, 10 out of 11 OHB samples were positive for anti-HBc (hepatitis B core antigen) antibody (all were immunoglobulin G). Seven had detectable anti-HBs. The serum HBV DNA levels were extremely low (highest 14.1 IU/ml). Of the six donors who underwent liver biopsies, all had normal liver biochemistry, extremely low liver HBV DNA (highest 6.21 copies/cell) and nearly normal liver histology. For those with viral sequence generation, none had the common HBsAg mutant G145R. Conclusions: The prevalence of OHB in a highly endemic area of chronic HBV was very low, thus implying a low impact on transfusion services. To implement universal screening, the high cost of NAT should be taken into account. OHB blood donors had very low HBV replication, and normal liver biochemistry and histology, conferring a favourable prognosis.
Persistent Identifierhttp://hdl.handle.net/10722/125086
ISSN
2023 Impact Factor: 23.0
2023 SCImago Journal Rankings: 8.052
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorLee, CKen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorFung, Jen_HK
dc.contributor.authorHung, Ien_HK
dc.contributor.authorHsu, Aen_HK
dc.contributor.authorBut, DYKen_HK
dc.contributor.authorCheung, TKen_HK
dc.contributor.authorChan, Pen_HK
dc.contributor.authorYuen, JCHen_HK
dc.contributor.authorFung, FKCen_HK
dc.contributor.authorSeto, WKen_HK
dc.contributor.authorLin, CKen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-10-31T11:10:35Z-
dc.date.available2010-10-31T11:10:35Z-
dc.date.issued2010en_HK
dc.identifier.citationGut, 2010, v. 59 n. 10, p. 1389-1393en_HK
dc.identifier.issn0017-5749en_HK
dc.identifier.urihttp://hdl.handle.net/10722/125086-
dc.description.abstractBackground and aims: The aim of the present study was to determine the population prevalence of occult hepatitis B (OHB) infection and its clinical profile in a highly endemic area of chronic hepatitis B virus disease. Methods: OHB was first identified by individual sample testing for hepatitis B surface antigen (HBsAg) followed by nucleic acid testing (NAT) and vice versa for 3044 (cohort 1, stored sera from donation within 1 year) and 9990 (cohort 2, prospective study) blood donors, respectively. OHB was confirmed meticulously by ≥2 out of 3 tests with detectable hepatitis B virus (HBV) DNA using a sensitive standardised assay. Detailed serology and viral load in the serum and liver were studied. Results: The prevalence of OHB was 0.13% (4/3044) and 0.11% (11/9967) for cohort 1 and 2, respectively. In cohort 2, 10 out of 11 OHB samples were positive for anti-HBc (hepatitis B core antigen) antibody (all were immunoglobulin G). Seven had detectable anti-HBs. The serum HBV DNA levels were extremely low (highest 14.1 IU/ml). Of the six donors who underwent liver biopsies, all had normal liver biochemistry, extremely low liver HBV DNA (highest 6.21 copies/cell) and nearly normal liver histology. For those with viral sequence generation, none had the common HBsAg mutant G145R. Conclusions: The prevalence of OHB in a highly endemic area of chronic HBV was very low, thus implying a low impact on transfusion services. To implement universal screening, the high cost of NAT should be taken into account. OHB blood donors had very low HBV replication, and normal liver biochemistry and histology, conferring a favourable prognosis.en_HK
dc.languageengen_HK
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/en_HK
dc.relation.ispartofGuten_HK
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshBlood Donors - statistics and numerical data-
dc.subject.meshCarrier State - epidemiology - pathology-
dc.subject.meshHepatitis B, Chronic - epidemiology - pathology-
dc.titlePrevalence of occult hepatitis B infection in a highly endemic area for chronic hepatitis B: A study of a large blood donor populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0017-5749&volume=59&issue=10&spage=1389&epage=1393&date=2010&atitle=Prevalence+of+occult+hepatitis+B+infection+in+a+highly+endemic+area+for+chronic+hepatitis+B:+a+study+of+a+large+blood+donor+populationen_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailFung, J: jfung@sicklehut.comen_HK
dc.identifier.emailHung, I: ivanhung@hkucc.hku.hken_HK
dc.identifier.emailSeto, WK: wkseto2@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityFung, J=rp00518en_HK
dc.identifier.authorityHung, I=rp00508en_HK
dc.identifier.authoritySeto, WK=rp01659en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1136/gut.2010.209148en_HK
dc.identifier.pmid20675695-
dc.identifier.scopuseid_2-s2.0-77957190181en_HK
dc.identifier.hkuros179939en_HK
dc.identifier.hkuros213682-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77957190181&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume59en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1389en_HK
dc.identifier.epage1393en_HK
dc.identifier.isiWOS:000282661300017-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridLee, CK=36087620900en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridFung, J=23091109300en_HK
dc.identifier.scopusauthoridHung, I=7006103457en_HK
dc.identifier.scopusauthoridHsu, A=16204995400en_HK
dc.identifier.scopusauthoridBut, DYK=24343113400en_HK
dc.identifier.scopusauthoridCheung, TK=7103334158en_HK
dc.identifier.scopusauthoridChan, P=7403497841en_HK
dc.identifier.scopusauthoridYuen, JCH=7102620480en_HK
dc.identifier.scopusauthoridFung, FKC=36604274400en_HK
dc.identifier.scopusauthoridSeto, WK=23390675900en_HK
dc.identifier.scopusauthoridLin, CK=12752556900en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.issnl0017-5749-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats