Estimating transmission dynamics of COVID-19 from cross-sectional viral load distributions in the roll-out of vaccination programs

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Grant Data
Project Title
Estimating transmission dynamics of COVID-19 from cross-sectional viral load distributions in the roll-out of vaccination programs
Principal Investigator
Dr Leung, Sze Man Kathy   (Principal Investigator (PI))
Co-Investigator(s)
Professor Wu Joseph Tsz Kei   (Co-Investigator)
Dr Lau Eric Ho Yin   (Co-Investigator)
Duration
19
Start Date
2022-09-01
Amount
531260
Conference Title
Estimating transmission dynamics of COVID-19 from cross-sectional viral load distributions in the roll-out of vaccination programs
Presentation Title
Keywords
COVID-19, Ct value, epidemiology, SARS-CoV-2, vaccination, viral load
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
21200122
Grant Type
Health and Medical Research Fund - Full Grant
Funding Year
2021
Status
On-going
Objectives
We propose to develop a model to estimate the effective reproductive number (Rt) in real-time by integrating the cross-sectional distributions of Ct values. If data are sufficient, we will also compare the distributions of Ct values from vaccinated and unvaccinated infections to estimate the vaccine efficacy in reducing mild or asymptomatic infections and hence transmissibility of COVID-19