Monitoring the transmission advantage of mutant strains of SARS-CoV-2

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Grant Data
Project Title
Monitoring the transmission advantage of mutant strains of SARS-CoV-2
Principal Investigator
Dr Leung, Sze Man Kathy   (Principal Investigator (PI))
Co-Investigator(s)
Dr Lam Tsan Yuk   (Co-Investigator)
Professor Wu Joseph Tsz Kei   (Co-Investigator)
Duration
24
Start Date
2021-10-01
Amount
856102
Conference Title
Monitoring the transmission advantage of mutant strains of SARS-CoV-2
Presentation Title
Keywords
coronavirus, COVID-19, fitness, mutant, phylogenetics, SARS-CoV-2
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
06200097
Grant Type
HMRF Research Fellowship Scheme
Funding Year
2021
Status
On-going
Objectives
The SARS-CoV-2 lineage carrying the amino acid change D614G has become the dominant variant in the global COVID-19 pandemic. The rapid spread of G614 suggests it may have a transmission advantage over the wildtype D614. However, no assessment has been conducted to date to quantify the epidemiological the wildtype D614. However, no assessment has been conducted to date to quantify the epidemiological fitness of G614 compared with its wildtype counterpart D614. Our aim is to perform a systematic evaluation of epidemiological fitness of other SARS-CoV-2 mutant strains that are becoming more prevalent during the COVID-19 pandemic.