The role of smoking on the regulation of ACE2-mediated infectability of COVID-19
Grant Data
Project Title
The role of smoking on the regulation of ACE2-mediated infectability of COVID-19
Principal Investigator
Dr Mak, Judith Choi Wo
(Principal Investigator (PI))
Co-Investigator(s)
Dr Liang Yingmin
(Co-Investigator)
Dr Hui Pui Yan
(Co-Investigator)
Dr Chan Michael Chi Wai
(Co-Investigator)
Duration
12
Start Date
2020-12-01
Amount
1997000
Conference Title
The role of smoking on the regulation of ACE2-mediated infectability of COVID-19
Presentation Title
Keywords
infectability of COVID-19, smoking on the regulation of ACE2
Discipline
Others - Medicine, Dentistry and Health
HKU Project Code
COVID190201
Grant Type
Commissioned Research on the Novel Coronavirus Disease (COVID-19)
Funding Year
2020
Status
On-going
Objectives
The broad goal of this research is to exploit how the expression of angiotensin-converting enzyme 2 (??ACE2) is regulated in airway epithelia under smoking in vitro and in vivo before and after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Emphasis will be placed on its roles in viral replication and renin-angiotensin system (RAS) in relation to disease severity.