Molecular control of hypertrophic chondrocyte cell fate and lineage extension
Grant Data
Project Title
Molecular control of hypertrophic chondrocyte cell fate and lineage extension
Principal Investigator
Professor Cheah, Kathryn Song Eng
(Principal Investigator (PI))
Co-Investigator(s)
Professor Zhou Zhongjun
(Co-Investigator)
Professor Chan Danny
(Co-Investigator)
Duration
42
Start Date
2018-01-01
Amount
1229763
Conference Title
Molecular control of hypertrophic chondrocyte cell fate and lineage extension
Presentation Title
Keywords
adipogenesis, irx transcription factors, osteogenesis, skeletal development, wnt signaling
Discipline
Developmental Biology,Disease Model Development
Panel
Biology and Medicine (M)
HKU Project Code
17129017
Grant Type
General Research Fund (GRF)
Funding Year
2017
Status
Completed
Objectives
1 a) Identify and define transition states and lineage hierarchy in the HC-Ob lineage extension and b) determine the molecular impact of Ctnnb1 deficiency on HC-Ob transition states. 2 Determine the roles and relationship between Ctnnb1-mediated Wnt signaling, and Irx3 and Irx5 in HC-Ob lineage transitions and control of osteogenesis versus adipogenesis 3 Integrate results and formulate mechanistic model of Ctnnb1-Irx3/5 gene regulatory network control of HC cell fate