Significance of novel mutations detected by serial whole exome sequencing in relapsed or refractory acute promyelocytic leukaemia resistant to arsenic trioxide
Grant Data
Project Title
Significance of novel mutations detected by serial whole exome sequencing in relapsed or refractory acute promyelocytic leukaemia resistant to arsenic trioxide
Principal Investigator
Professor Singh, Gill Harinder Harry
(Principal Investigator (PI))
Duration
12
Start Date
2017-01-01
Amount
44320
Conference Title
Significance of novel mutations detected by serial whole exome sequencing in relapsed or refractory acute promyelocytic leukaemia resistant to arsenic trioxide
Keywords
Acute promyelocytic leukaemia, arsenic trioxide, resistance
Discipline
Blood/HematologyCancer
HKU Project Code
201611159024
Grant Type
Seed Fund for PI Research – Basic Research
Funding Year
2016
Status
On-going
Objectives
1. To determine the functional role of novel mutations detected using whole exome sequencing in patients with acute promyelocytic leukaemia demonstrating resistance to arsenic trioxide 2. To determine the frequencies of these mutations in a cohort of patients with with acute promyelocytic leukaemia refractory to arsenic trioxide.