Rationalizing scaffold design with optimal cell niche for mesenchymal stem cell-based therapy in disc degeneration


Grant Data
Project Title
Rationalizing scaffold design with optimal cell niche for mesenchymal stem cell-based therapy in disc degeneration
Principal Investigator
Professor Chan, Barbara Pui   (Principal Investigator (PI))
Co-Investigator(s)
Professor Du Yanan   (Co-principal investigator)
Duration
48
Start Date
2015-01-01
Amount
1098911
Conference Title
Rationalizing scaffold design with optimal cell niche for mesenchymal stem cell-based therapy in disc degeneration
Presentation Title
Keywords
intervertebral disc degeneration, mesenchymal stem cell, multiphoton photochemical crosslinking, Stem cell niche
Discipline
Biomedical Engineering,Biomaterials
Panel
Engineering (E)
HKU Project Code
N_HKU713/14
Grant Type
External Grant
Funding Year
2014
Status
Completed
Objectives
1) To screen for the optimal cell niche maintaining phenotype and function of NP cells; 2) To study MSC fate and phenotypic changes upon exposure to the optimal cell niche; 3) To translate the optimal cell niche into scaffold design for IVD tissue engineering