A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications

Professor Man Kwan   (Co-principal investigator)

Professor Guan Xin-Yuan   (Co-principal investigator)

Professor Lo Chung Mau   (Co-principal investigator)

36

2015-06-15

5327100

A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications

CD133, HBV, liver cancer, organoid, tumor-initiating cells

CancerMolecular Biology

C7027-14G

Collaborative Research Fund (CRF) - Group Research Project

2014

Completed

1) To examine the role of Hepatitis B virus (HBV) oncoprotein, truncated HBx (HBx-ΔC) in the regulation of CSC-like properties in CD133+ HCC via modulating distinct differentiation and growth signaling pathways. 2) To characterize the functional roles of deregulated genes and signaling pathways, with particular relevance to chromatin modification enzymes and redox regulation, in the maintenance, progression and differentiation of CD133+ liver CSCs. 3) To compare the differential transcriptomic and epigenomic profile between CD133+ cells isolated from fetal liver, non-tumor liver and HCC patient organoid culture lines.