Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Grant Data
Project Title
Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Principal Investigator
Professor Guan, Xin-Yuan
(Project Coordinator (PC))
Co-Investigator(s)
Dr Fu Grace Li
(Co-principal investigator)
Professor Chen Zhiwei
(Co-principal investigator)
Professor Ma Stephanie Kwai Yee
(Co-principal investigator)
Duration
36
Start Date
2015-04-01
Amount
3487091
Conference Title
Investigation of effects and molecular mechanisms of FGFR2-positive cancer-associate fibroblasts on tumor microenvironment in esophageal squamous cell carcinoma
Presentation Title
Keywords
cancer microenvironment, cancer-associated fibroblast, esophageal cancer, FGFR2, immune surveillance
Discipline
Cancer,Cell Biology
HKU Project Code
C7038-14G
Grant Type
Collaborative Research Fund (CRF) - Group Research Project
Funding Year
2014
Status
Completed
Objectives
1) To characterize FGFR2+ cancer-associated fibroblasts (CAFs) in ESCC; 2) To investigate the effect of FGFR2+ CAFs on ESCC stemness; 3) To study the role of d42PD1/TLR4 pathway in modulating host immune surveillance.
All Publications
Title | Author(s) | Issue Date | |
---|---|---|---|
TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling Journal:Nature Communications | 2018 | ||
RNA editing of SLC22A3 drives early tumor invasion and metastasis in familial esophageal cancer Journal:Proceedings of the National Academy of Sciences | 2017 | ||
2018 | |||
2016 | |||
2015 | |||
Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma Journal:Nature Communications | 2016 | ||
2017 | |||
Expansion of cancer stem cell pool initiates lung cancer recurrence before angiogenesis Journal:Proceedings of the National Academy of Sciences | 2018 | ||
2016 |