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Conference Paper: Tax-induced recruitment of TORC family coactivators is required for transcriptional activation of HTLV-I LTR

TitleTax-induced recruitment of TORC family coactivators is required for transcriptional activation of HTLV-I LTR
Authors
Issue Date2007
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aid
Citation
The 13th International Conference on Human Retrovirology HTLV and Related Viruses, Hakone, Japan, 21-25 May 2007. In AIDS Research and Human Retroviruses, 2007, v. 23 n. 4, p. 646 How to Cite?
AbstractHTLV-I Tax is pivotally involved in leukemogenesis, and it potently transactivates viral transcription from the LTR. Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. We have recently shown that all three members of the newly identified TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3, relocating them to specific intranuclear subdomains. a chromatin immunoprecipitation assay indicates an association of TORC1, TORC2, and TORC3 with the 21-bp repeats of the HTLV-1 LTR. Depletion of TORC coactivators was accomplished using RNAi-inhibited Tax-dependent transcriptional activation of HTLV-1 LTR. Thus, TORC members are essential Tax coactivators for viral transcription.
Persistent Identifierhttp://hdl.handle.net/10722/95970
ISSN
2015 Impact Factor: 1.949
2015 SCImago Journal Rankings: 1.024

 

DC FieldValueLanguage
dc.contributor.authorSiu, YTen_HK
dc.contributor.authorJin, Den_HK
dc.date.accessioned2010-09-25T16:19:16Z-
dc.date.available2010-09-25T16:19:16Z-
dc.date.issued2007en_HK
dc.identifier.citationThe 13th International Conference on Human Retrovirology HTLV and Related Viruses, Hakone, Japan, 21-25 May 2007. In AIDS Research and Human Retroviruses, 2007, v. 23 n. 4, p. 646en_HK
dc.identifier.issn0889-2229en_HK
dc.identifier.urihttp://hdl.handle.net/10722/95970-
dc.description.abstractHTLV-I Tax is pivotally involved in leukemogenesis, and it potently transactivates viral transcription from the LTR. Mechanisms through which Tax activates LTR have been established, but coactivators of this process remain to be identified and characterized. We have recently shown that all three members of the newly identified TORC family of transcriptional regulators are coactivators of Tax for LTR-driven expression. TORC coactivation requires CREB, but not ATF4 or other bZIP factors. Tax physically interacts with TORC1, TORC2, and TORC3, relocating them to specific intranuclear subdomains. a chromatin immunoprecipitation assay indicates an association of TORC1, TORC2, and TORC3 with the 21-bp repeats of the HTLV-1 LTR. Depletion of TORC coactivators was accomplished using RNAi-inhibited Tax-dependent transcriptional activation of HTLV-1 LTR. Thus, TORC members are essential Tax coactivators for viral transcription.-
dc.languageengen_HK
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/aiden_HK
dc.relation.ispartofAIDS Research and Human Retrovirusesen_HK
dc.titleTax-induced recruitment of TORC family coactivators is required for transcriptional activation of HTLV-I LTRen_HK
dc.typeConference_Paperen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0889-2229&volume=23&spage=646&epage=&date=2007&atitle=Tax-induced+recruitment+of+TORC+family+coactivators+is+required+for+transcriptional+activation+of+HTLV-I+LTRen_HK
dc.identifier.emailSiu, YT: ytsiu@hkucc.hku.hken_HK
dc.identifier.emailJin, D: dyjin@hkucc.hku.hken_HK
dc.identifier.authorityJin, D=rp00452en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1089/aid.2007.9997-
dc.identifier.hkuros127317en_HK
dc.identifier.hkuros127313-
dc.identifier.volume23en_HK
dc.identifier.spage646en_HK

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