Professor Jin, DY 金冬雁
I did my PhD study with Prof. Yun-De Hou at the State Key Laboratory for Molecular Virology in Beijing in 1986-1991. I received postdoctoral training with Dr. Kuan-Teh Jeang at the National Institute of Allergy and Infectious Diseases in 1994-1999. I joined the University of Hong Kong in 1999 and am now a Professor in the Department of Biochemistry.
My research is focusing primarily on the molecular basis of viral diseases and cancer. We use a combination of biochemical and genetic approaches to conduct basic research in molecular virology and oncology with the aim of applying the knowledge gained to prevention and control of human diseases. In my study of a viral oncogenic protein named Tax produced by human T-cell leukemia virus type 1, which causes a highly lethal blood cancer known as adult T-cell leukemia, I identified in 1998 a cellular protein named MAD1, a key component of a cell cycle checkpoint that guard against abnormal division of cells. In 2006, my group characterized another cellular protein, which is also crippled by Tax to give rise to abnormal numbers of chromosomes in leukemic cells. Our work in 2008 revealed how Epstein-Barr virus uses a viral small RNA molecule to promote the survival of tumor cells in nasopharyngeal carcinoma. In 2011, we found that the virus sensor RIG-I needs an RNA-binding protein partner called PACT to initiate and sustain host antiviral defense.
One major area of my current research is in the regulatory mechanism of innate antiviral response. Novel cellular and viral regulatory factors that govern antiviral response will be identified and characterized. Particularly, cellular machinery to sense viral nucleic acids, features of viral nucleic acids being sensed, and enzymes that cleave the second messenger will be dissected. We aspire to substantially advance current understanding of viral and cellular regulators of innate antiviral response. Our findings might also reveal novel strategies for developing antiviral and immunomodulatory agents including vaccine adjuvants.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2004-10-01||Science Press Golden Jubilee Award for Outstanding Scientific Publication: Science Press, Beijing, China||Others|
|1998-07-01||(U.S.) National Institutes of Health Fellows Award for Research Excellence (FARE)||Research Achievement|
|2014-01-01||Croucher Senior Research Fellowship (Croucher Award, 2014): Croucher Foundation||Research Achievement|
|2007-07-01||2007 Faculty Research Output Prize: The University of Hong Kong, Nature Cell Biology||Research Achievement|
|1998-07-01||(U.S.) National Institutes of Health Fogarty Visiting Fellow Award, 1997-1998||Research Achievement|
|2008-12-01||Outstanding Researcher Award 2008-2009: University of Hong Kong||Research Achievement|
|2004-04-01||Characterization Of Novel Putative Tumor Suppressor Gene, DLC2 (deleted In Liver Cancer 2), In Hepatocellular Carcinoma: 95th American Association For Cancer Research Annual Meeting, Florida, 2004||Research Achievement|
|2012-02-01||Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract: 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society||Research Achievement|
|2002-07-01||Global Research Initiative Program (GRIP) New Foreign Investigator Award (2002-2007): Fogarty International Center, National Institutes of Health||Research Achievement|
|2001-04-01||Leukemia and Lymphoma Society Scholar Award (2001-2006): Leukemia and Lymphoma Society||Research Achievement|
|2001-12-01||National Natural Science Award of China: State Council, PR China||Research Achievement|
|2002-01-01||National Outstanding Young Investigator Award (Category B): Nantional Natural Science Foundation of China, 國家傑出青年基金(B類), 國家自然科學基金會||Research Achievement|
|2004-12-01||Identification of multiple isoforms of DLC2, a novel tumor suppressor gene, and their functional characterization in hepatocellular carcinoma: the 4th International Meeting Hepatocellular Carcinoma: Eastern and Western Experiences, 2004||Research Achievement|
|2015-01-01||Outstanding Research Student Supervisor Award: The University of Hong Kong||Teaching Accomplishment|
|2016-09-01||Poster Presentation Award of Annual Scientific Meeting of the Hong Kong Society for Immunology 2016: the Hong Kong Society for Immunology||Research Achievement|
|Term Period||Position||Professional Societies|
|Life-time||Full Member||Society of Chinese Bioscientists in America|
|01/2005-date||Full Member||American Society for Cell Biology|
|Life-time||Full Member||The Society of Hong Kong Scholars|
|01/2000-date||Full Member||American Society for Microbiology|
|Life-time||Council Member||Hong Kong Society of Biochemistry and Molecular Biology|
|Life-time||Full Member||American Society for Virology|
|1/2014-date||Full Member||International Association for Research on Epstein-Barr Virus and Associated Diseases (EBV Association)|
|1/2014-date||Council Member||Hong Kong Society for Immunology|
|1/2013-date||Full Member||International Retrovirology Association|
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