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Article: Obesity susceptibility genetic variants identified from recent genome-wide association studies: Implications in a Chinese population

TitleObesity susceptibility genetic variants identified from recent genome-wide association studies: Implications in a Chinese population
Authors
Issue Date2010
PublisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.org
Citation
Journal Of Clinical Endocrinology And Metabolism, 2010, v. 95 n. 3, p. 1395-1403 How to Cite?
AbstractContext: Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants. Objective: This study aimed to examine 13 previously reported obesity and/or BMI-associated loci for associations with obesity in Chinese. Design and Study Participants: This was a cross-sectional case-control study in 470 obese cases (BMI ≥27.5 kg/m 2) and 700 normal-weight controls (18.5 ≤ BMI ≤ 23.0 kg/m 2). Results: A significant association with obesity could be replicated (one tailed P<0.05) in seven of the 13 single-nucleotide polymorphisms (SNPs) in the case-control study. These included GNPDA2 rs10938397 (P=7.3X10 -4); FTO rs8050136 (P=8X10 -4);MC4Rrs17782313 (P=1.2X10 -3); KCTD15 rs29941 (P = 8 X 10 -3); SFRS10-ETV5-DGKG rs7647305 (P = 0.023); SEC16B-RASAL2 rs10913469 (P = 0.041); and NEGR1 rs3101336 (P = 0.046). Combined genetic risk scores were calculated, and we observed ORs ranging from 1.17 to 1.23 for each unit increase in the genetic risk scores. Associations with obesity-related quantitative traits were analyzed separately for cases and controls. KCTD15 SNP rs29941 (P=1X10 -3) was significantly associated with fasting glucose in the control group, whereas only the FTO SNP rs8050136 was associated with BMI (P=3.5X10 -3) in the obese group. However, in an extension study of 1938 subjects from the population-based Hong Kong Cardiovascular Risk Factors Prevalence Study, rs8050136, rs10938397, and rs17782313 showed significant associations with BMI. Conclusion: We have succeeded in replicating, in a Chinese population, the associations with obesity in seven SNPs reported in recent genome-wide association studies. Further functional and fine-mapping studies to elucidate the roles of these putative obesity-related genes and genetic variants are warranted. Copyright © 2010 by The Endocrine Society.
Persistent Identifierhttp://hdl.handle.net/10722/91512
ISSN
2015 Impact Factor: 5.531
2015 SCImago Journal Rankings: 2.940
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

This study was financially supported by the Committee on Research and Conference Grants seeding fund for basic research from the University of Hong Kong (to K.S.L.L.) C.Y.Y.C. and K.L.O. are recipients of the University of Hong Kong postgraduate fellowships. P.C.S. received support from the Genomics Strategic Research Theme of the University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorCheung, CYYen_HK
dc.contributor.authorTso, AWKen_HK
dc.contributor.authorCheung, BMYen_HK
dc.contributor.authorXu, Aen_HK
dc.contributor.authorOng, KLen_HK
dc.contributor.authorFong, CHYen_HK
dc.contributor.authorWat, NMSen_HK
dc.contributor.authorJanus, EDen_HK
dc.contributor.authorSham, PCen_HK
dc.contributor.authorLam, KSLen_HK
dc.date.accessioned2010-09-17T10:20:36Z-
dc.date.available2010-09-17T10:20:36Z-
dc.date.issued2010en_HK
dc.identifier.citationJournal Of Clinical Endocrinology And Metabolism, 2010, v. 95 n. 3, p. 1395-1403en_HK
dc.identifier.issn0021-972Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/91512-
dc.description.abstractContext: Recent large-scale genome-wide association studies identified novel genetic variants associated with obesity and body mass index (BMI) in addition to the well-described FTO and MC4R genetic variants. Objective: This study aimed to examine 13 previously reported obesity and/or BMI-associated loci for associations with obesity in Chinese. Design and Study Participants: This was a cross-sectional case-control study in 470 obese cases (BMI ≥27.5 kg/m 2) and 700 normal-weight controls (18.5 ≤ BMI ≤ 23.0 kg/m 2). Results: A significant association with obesity could be replicated (one tailed P<0.05) in seven of the 13 single-nucleotide polymorphisms (SNPs) in the case-control study. These included GNPDA2 rs10938397 (P=7.3X10 -4); FTO rs8050136 (P=8X10 -4);MC4Rrs17782313 (P=1.2X10 -3); KCTD15 rs29941 (P = 8 X 10 -3); SFRS10-ETV5-DGKG rs7647305 (P = 0.023); SEC16B-RASAL2 rs10913469 (P = 0.041); and NEGR1 rs3101336 (P = 0.046). Combined genetic risk scores were calculated, and we observed ORs ranging from 1.17 to 1.23 for each unit increase in the genetic risk scores. Associations with obesity-related quantitative traits were analyzed separately for cases and controls. KCTD15 SNP rs29941 (P=1X10 -3) was significantly associated with fasting glucose in the control group, whereas only the FTO SNP rs8050136 was associated with BMI (P=3.5X10 -3) in the obese group. However, in an extension study of 1938 subjects from the population-based Hong Kong Cardiovascular Risk Factors Prevalence Study, rs8050136, rs10938397, and rs17782313 showed significant associations with BMI. Conclusion: We have succeeded in replicating, in a Chinese population, the associations with obesity in seven SNPs reported in recent genome-wide association studies. Further functional and fine-mapping studies to elucidate the roles of these putative obesity-related genes and genetic variants are warranted. Copyright © 2010 by The Endocrine Society.en_HK
dc.languageengen_HK
dc.publisherThe Endocrine Society. The Journal's web site is located at http://jcem.endojournals.orgen_HK
dc.relation.ispartofJournal of Clinical Endocrinology and Metabolismen_HK
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAsian Continental Ancestry Group - genetics-
dc.subject.meshGenetic Predisposition to Disease - genetics-
dc.subject.meshObesity - genetics - metabolism-
dc.titleObesity susceptibility genetic variants identified from recent genome-wide association studies: Implications in a Chinese populationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0021-972X&volume=95&issue=3&spage=1395&epage=1403&date=2010&atitle=Obesity+susceptibility+genetic+variants+identified+from+recent+genome-wide+association+studies:+implications+in+a+chinese+population-
dc.identifier.emailTso, AWK: awk.tso@gmail.comen_HK
dc.identifier.emailCheung, BMY: mycheung@hku.hken_HK
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_HK
dc.identifier.emailSham, PC: pcsham@hku.hken_HK
dc.identifier.emailLam, KSL: ksllam@hku.hken_HK
dc.identifier.authorityTso, AWK=rp00535en_HK
dc.identifier.authorityCheung, BMY=rp01321en_HK
dc.identifier.authorityXu, A=rp00485en_HK
dc.identifier.authoritySham, PC=rp00459en_HK
dc.identifier.authorityLam, KSL=rp00343en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1210/jc.2009-1465en_HK
dc.identifier.pmid20061430-
dc.identifier.scopuseid_2-s2.0-77749233777en_HK
dc.identifier.hkuros175935-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77749233777&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume95en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1395en_HK
dc.identifier.epage1403en_HK
dc.identifier.isiWOS:000275197500052-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridCheung, CYY=36022243200en_HK
dc.identifier.scopusauthoridTso, AWK=6701371436en_HK
dc.identifier.scopusauthoridCheung, BMY=7103294806en_HK
dc.identifier.scopusauthoridXu, A=7202655409en_HK
dc.identifier.scopusauthoridOng, KL=8340854000en_HK
dc.identifier.scopusauthoridFong, CHY=14033917100en_HK
dc.identifier.scopusauthoridWat, NMS=6602131754en_HK
dc.identifier.scopusauthoridJanus, ED=7006936536en_HK
dc.identifier.scopusauthoridSham, PC=34573429300en_HK
dc.identifier.scopusauthoridLam, KSL=8082870600en_HK
dc.identifier.citeulike7211631-

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