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Article: Microsatellite instability in mitochondrial genome of common female cancers

TitleMicrosatellite instability in mitochondrial genome of common female cancers
Authors
KeywordsBreast cancer
Gynecological cancer
Mitochondrial DNA
Mitochondrial microsatellite instability
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/
Citation
International Journal Of Gynecological Cancer, 2006, v. 16 SUPPL. 1, p. 259-266 How to Cite?
AbstractTo investigate the occurrence of mitochondrial genome instability in primary cervical, endometrial, ovarian, and breast carcinomas, we analyzed 12 microsatellite regions in mitochondrial DNA (mtDNA) of tumor tissues and their matched normal controls. Four of the 12 microsatellite markers starting at nucleotide position (np) 303, 514, 956, and 16184, respectively, exhibited instability as indicated by the change in length of short base-repetitive sequences of mtDNA in cancer tissue relative to that in control normal tissue from the same patient. About 25.4% of cervical cancers, 48.4% of endometrial cancers, 21.9% of ovarian cancers, and 29.4% of breast cancers carried one or more mitochondrial microsatellite instability (mtMSI). mtMSI was frequently detected in the D-loop region but rarely occurred in the coding region. A relatively long C tract interrupted by a T residue is the mtMSI hot spot in all four types of cancer studied. Different tumors have different mtMSI profiles. In particular, the frequency of mtMSI in endometrial cancer was significantly higher than in the other three types of cancer. Furthermore, carriers of a germ-line T to C polymorphism at np 16189 could be more susceptible to breast cancer development in light of the higher frequency detected in cancer patients than in normal individuals. © 2006, IGCS.
Persistent Identifierhttp://hdl.handle.net/10722/87299
ISSN
2015 Impact Factor: 2.116
2015 SCImago Journal Rankings: 0.830
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_HK
dc.contributor.authorLiu, VWSen_HK
dc.contributor.authorTsang, PCKen_HK
dc.contributor.authorChiu, PMen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorNagley, Pen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:27:53Z-
dc.date.available2010-09-06T09:27:53Z-
dc.date.issued2006en_HK
dc.identifier.citationInternational Journal Of Gynecological Cancer, 2006, v. 16 SUPPL. 1, p. 259-266en_HK
dc.identifier.issn1048-891Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/87299-
dc.description.abstractTo investigate the occurrence of mitochondrial genome instability in primary cervical, endometrial, ovarian, and breast carcinomas, we analyzed 12 microsatellite regions in mitochondrial DNA (mtDNA) of tumor tissues and their matched normal controls. Four of the 12 microsatellite markers starting at nucleotide position (np) 303, 514, 956, and 16184, respectively, exhibited instability as indicated by the change in length of short base-repetitive sequences of mtDNA in cancer tissue relative to that in control normal tissue from the same patient. About 25.4% of cervical cancers, 48.4% of endometrial cancers, 21.9% of ovarian cancers, and 29.4% of breast cancers carried one or more mitochondrial microsatellite instability (mtMSI). mtMSI was frequently detected in the D-loop region but rarely occurred in the coding region. A relatively long C tract interrupted by a T residue is the mtMSI hot spot in all four types of cancer studied. Different tumors have different mtMSI profiles. In particular, the frequency of mtMSI in endometrial cancer was significantly higher than in the other three types of cancer. Furthermore, carriers of a germ-line T to C polymorphism at np 16189 could be more susceptible to breast cancer development in light of the higher frequency detected in cancer patients than in normal individuals. © 2006, IGCS.en_HK
dc.languageengen_HK
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/en_HK
dc.relation.ispartofInternational Journal of Gynecological Canceren_HK
dc.subjectBreast canceren_HK
dc.subjectGynecological canceren_HK
dc.subjectMitochondrial DNAen_HK
dc.subjectMitochondrial microsatellite instabilityen_HK
dc.subject.meshAdenocarcinoma - geneticsen_HK
dc.subject.meshBreast Neoplasms - geneticsen_HK
dc.subject.meshDNA, Mitochondrial - geneticsen_HK
dc.subject.meshEndometrial Neoplasms - geneticsen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshGenital Neoplasms, Female - geneticsen_HK
dc.subject.meshGenomic Instability - geneticsen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMicrosatellite Repeats - geneticsen_HK
dc.subject.meshMutationen_HK
dc.subject.meshOvarian Neoplasms - geneticsen_HK
dc.subject.meshPolymorphism, Geneticen_HK
dc.subject.meshUterine Cervical Neoplasms - geneticsen_HK
dc.titleMicrosatellite instability in mitochondrial genome of common female cancersen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1048-891X&volume=Suppl 1&spage=259&epage=266&date=2006&atitle=Microsatellite+instability+in+mitochondrial+genome+of+common+female+cancersen_HK
dc.identifier.emailLiu, VWS: vwsliu@hkusua.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.authorityLiu, VWS=rp00341en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1525-1438.2006.00412.xen_HK
dc.identifier.pmid16515601-
dc.identifier.scopuseid_2-s2.0-33645356201en_HK
dc.identifier.hkuros113123en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33645356201&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume16en_HK
dc.identifier.issueSUPPL. 1en_HK
dc.identifier.spage259en_HK
dc.identifier.epage266en_HK
dc.identifier.isiWOS:000236269900042-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridWang, Y=8637619000en_HK
dc.identifier.scopusauthoridLiu, VWS=7006405113en_HK
dc.identifier.scopusauthoridTsang, PCK=7102404070en_HK
dc.identifier.scopusauthoridChiu, PM=7103182596en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridNagley, P=7006184213en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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