Article: Microsatellite instability in mitochondrial genome of common female cancers

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleMicrosatellite instability in mitochondrial genome of common female cancers
AuthorsWang, Y1
Liu, VWS1
Tsang, PCK1
Chiu, PM1
Cheung, ANY1
Khoo, US1
Nagley, P2
Ngan, HYS1
KeywordsBreast cancer
Gynecological cancer
Mitochondrial DNA
Mitochondrial microsatellite instability
Issue Date2006
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/
CitationInternational Journal Of Gynecological Cancer, 2006, v. 16 SUPPL. 1, p. 259-266 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1525-1438.2006.00412.x
AbstractTo investigate the occurrence of mitochondrial genome instability in primary cervical, endometrial, ovarian, and breast carcinomas, we analyzed 12 microsatellite regions in mitochondrial DNA (mtDNA) of tumor tissues and their matched normal controls. Four of the 12 microsatellite markers starting at nucleotide position (np) 303, 514, 956, and 16184, respectively, exhibited instability as indicated by the change in length of short base-repetitive sequences of mtDNA in cancer tissue relative to that in control normal tissue from the same patient. About 25.4% of cervical cancers, 48.4% of endometrial cancers, 21.9% of ovarian cancers, and 29.4% of breast cancers carried one or more mitochondrial microsatellite instability (mtMSI). mtMSI was frequently detected in the D-loop region but rarely occurred in the coding region. A relatively long C tract interrupted by a T residue is the mtMSI hot spot in all four types of cancer studied. Different tumors have different mtMSI profiles. In particular, the frequency of mtMSI in endometrial cancer was significantly higher than in the other three types of cancer. Furthermore, carriers of a germ-line T to C polymorphism at np 16189 could be more susceptible to breast cancer development in light of the higher frequency detected in cancer patients than in normal individuals. © 2006, IGCS.
ISSN1048-891X
2011 Impact Factor: 1.646
2011 SCImago Journal Rankings: 0.181
DOIhttp://dx.doi.org/10.1111/j.1525-1438.2006.00412.x
ISI Accession Number IDWOS:000236269900042
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWang, Y
dc.contributor.authorLiu, VWS
dc.contributor.authorTsang, PCK
dc.contributor.authorChiu, PM
dc.contributor.authorCheung, ANY
dc.contributor.authorKhoo, US
dc.contributor.authorNagley, P
dc.contributor.authorNgan, HYS
dc.date.accessioned2010-09-06T09:27:53Z
dc.date.available2010-09-06T09:27:53Z
dc.date.issued2006
dc.description.abstractTo investigate the occurrence of mitochondrial genome instability in primary cervical, endometrial, ovarian, and breast carcinomas, we analyzed 12 microsatellite regions in mitochondrial DNA (mtDNA) of tumor tissues and their matched normal controls. Four of the 12 microsatellite markers starting at nucleotide position (np) 303, 514, 956, and 16184, respectively, exhibited instability as indicated by the change in length of short base-repetitive sequences of mtDNA in cancer tissue relative to that in control normal tissue from the same patient. About 25.4% of cervical cancers, 48.4% of endometrial cancers, 21.9% of ovarian cancers, and 29.4% of breast cancers carried one or more mitochondrial microsatellite instability (mtMSI). mtMSI was frequently detected in the D-loop region but rarely occurred in the coding region. A relatively long C tract interrupted by a T residue is the mtMSI hot spot in all four types of cancer studied. Different tumors have different mtMSI profiles. In particular, the frequency of mtMSI in endometrial cancer was significantly higher than in the other three types of cancer. Furthermore, carriers of a germ-line T to C polymorphism at np 16189 could be more susceptible to breast cancer development in light of the higher frequency detected in cancer patients than in normal individuals. © 2006, IGCS.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal Of Gynecological Cancer, 2006, v. 16 SUPPL. 1, p. 259-266 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1525-1438.2006.00412.x
dc.identifier.doihttp://dx.doi.org/10.1111/j.1525-1438.2006.00412.x
dc.identifier.epage266
dc.identifier.hkuros113123
dc.identifier.isiWOS:000236269900042
dc.identifier.issn1048-891X
2011 Impact Factor: 1.646
2011 SCImago Journal Rankings: 0.181
dc.identifier.issueSUPPL. 1
dc.identifier.openurl
dc.identifier.pmid16515601
dc.identifier.scopuseid_2-s2.0-33645356201
dc.identifier.spage259
dc.identifier.urihttp://hdl.handle.net/10722/87299
dc.identifier.volume16
dc.languageeng
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/
dc.publisher.placeUnited States
dc.relation.ispartofInternational Journal of Gynecological Cancer
dc.relation.referencesReferences in Scopus
dc.subject.meshAdenocarcinoma - genetics
dc.subject.meshBreast Neoplasms - genetics
dc.subject.meshDNA, Mitochondrial - genetics
dc.subject.meshEndometrial Neoplasms - genetics
dc.subject.meshFemale
dc.subject.meshGenital Neoplasms, Female - genetics
dc.subject.meshGenomic Instability - genetics
dc.subject.meshHumans
dc.subject.meshMicrosatellite Repeats - genetics
dc.subject.meshMutation
dc.subject.meshOvarian Neoplasms - genetics
dc.subject.meshPolymorphism, Genetic
dc.subject.meshUterine Cervical Neoplasms - genetics
dc.subjectBreast cancer
dc.subjectGynecological cancer
dc.subjectMitochondrial DNA
dc.subjectMitochondrial microsatellite instability
dc.titleMicrosatellite instability in mitochondrial genome of common female cancers
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Monash University