Name Card
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Professor Ngan, Hextan Yuen Sheung 顏婉嫦

Title:
Professor, Chair of Obstetrics and Gynaecology
Tsao Yin Kai Professor in Obstetrics & Gynaecology
Clinical Professor
Head, Department of Obstetrics and Gynaecology
Tsao Yin-Kai Professorship in Obstetrics and Gynaecology
Honorary Clinical Professor

Contact Information
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Tel:
2255 4260
Office:

Professor Ngan, Hextan Yuen Sheung 顏婉嫦

Title:
Professor, Chair of Obstetrics and Gynaecology
Tsao Yin Kai Professor in Obstetrics & Gynaecology
Clinical Professor
Head, Department of Obstetrics and Gynaecology
Tsao Yin-Kai Professorship in Obstetrics and Gynaecology
Honorary Clinical Professor

Also Cited As:
Ngan, Yuen-sheung, Hextan
Ngan, YS
Ngan, HY
Ngan, H
Hextan

Biography

Prof. Hextan YS Ngan is a Chair Professor and the Head of Department of Obstetrics & Gynaecology, the University of Hong Kong. She is also the team leader of Oncology Division of this department. Her research interests include basic, clinical and translational cancer research in gynaecology oncology. Her basic research interests have focus on the characterization of putative oncogenes and tumor suppressor genes, as well as their associated signaling pathways involved in the pathogenesis of ovarian, endometrial and cervical carcinomas. Her research group was the first to identify p73alpha is involved in enhancement of the radiosensitive in cervical cancer cells through with the upregulation of p21. Importantly, her group has recently found that the breast cancer–associated gene 3 (BCA3) acts as a novel protein interacting partner of TAp73 and potentiates TAp73 in mediating γ-irradiation–induced apoptosis. These studies reveal the significance of p73 in the radiosensitivity of cervical cancer cells. Moreover, her group has recently reported an important oncogenic transcriptional factor, FOXM1, is frequently overexpressed in cervical and ovarian cancers, and is significantly correlated with the progression and aggressiveness of these cancers. The inhibitory targeting of FOXM1 by RNAi, specific inhibitor e.g. thiostrepton, or even AMPK activators such as metformin could remarkably abrogate the oncogenic capacities of these cancer cells. Ovarian cancer is a relatively poor survival rate disease because of chemoresistance and high rate in tumor recurrence. Hence, her group is particularly interested in the delineation of the underlying mechanisms associated with tumorigenesis and chemoresistance of this disease. Recent studies her group has not only identified the oncogenic role of FOXM1 in ovarian cancer, they also have found the signaling adaptors, GRB7 and its variant GRB7v, are aberrantly upregulated and associated with a variety of oncogenic capacities by modulating differential signaling pathways. These findings may shed the light of exploring potential therapeutic interventions through targeting these genes. Future studies will include the study of the impacts of tumor microenvironment and cancer cell metabolism on these key pathways involved in the aggressiveness and chemoresistance of ovarian cancer.

Her clinical translational research effort have focused on cervical cancer screening especially on the role of HPV testing as well as on psychosocial studies including quality of life. In addition, the identification of new molecular markers in addition to routine HPV screening test is another area of her interested research. Currently her group is conducting a study to compare different HPV test. Lastly, her group has also taken part in contract clinical trials mainly in ovarian cancer treatment and HPV vaccines.

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
CAI, C
2012-12-01The Best Oral Presentation: The 17th Research Postgraduate Symposium December 13-14, 2012
Research Achievement
Leung, THY
2010-02-01Interaction of TAp73 and BCA3 enhances the sensitivity of cervical cancer cells in response to irradiation-induced apoptosis. AACR Scholar-in-Training Award: AACR Special conference: Cell death mechanism and cancer therapy, 2010 (San Diego, USA)
Research Achievement
Wong, GW
Chan, KY
Yang, MS
Tsang, CH
Ji, SL
Lo, CK
Szeto, E
Wong, ESY
2010-09-01Integrated Human Papilloma Virus Analysis as Adjunct for Triage of Atypical Cervical Cytology.: Health Research Symposium 2010, 11 Sept 2010 organised by Food and Health Bureau, HKSAR. - Best RFCID Poster Presentation Award
Research Achievement
2003-03-01p73 expression and radiosensitivity in cervical carcinomas/Abstract/ AACR Scholar-in-training award: American Association for Cancer Research (AACR) 94th annual meeting
Research Achievement
2013-09-01Gold Medal in recognition of the significant contribution to our knowledge of trophoblastic disease at the conference: International Society for the Study of Trophoblastic Diseases (ISSTD), VII World Congress on Gestational Trophoblasic Diseases, September 19-23
Research Achievement
KWAN, HT
2010-12-01The outstanding poster presentation: The 15th Research Postgraduate Symposium December 1-2, 2010
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
2009-2012ChairmanEducation Committee of the Hong Kong College of Obstetricians and Gynaecologists
01/2004-12/2006AdvisorWHO Technical Advisory Group on Comprehensive Cervical Cancer Control: a guide for essential practice
01/2006-12/2007ChairmanGynaecological Oncology Subspecialty Board of the Hong Kong College of Obstetricians and Gynaecologists
01/2003-12/2003SecretaryGynaecological Oncology Subspecialty Board of the Hong Kong College of Obstetricians and Gynaecologists
01/1996-12/2009Council memberAsia and Oceania Federation of Obstetrics and Gynaecology
05/2006-11/2006TreasurerAsia and Oceania Federation of Obstetrics and Gynaecology
01/2003-12/2004MemberColposcopy Accreditation Sub-committee of the Hong Kong College of Obstetricians and Gynaecologists
01/2007-12/2009Senior Vice-PresidentHong Kong College of Obstetricians and Gynaecologists
01/2004-12/2006Junior Vice-PresidentHong Kong College of Obstetricians and Gynaecologists
01/2003-12/2006MemberInternational Gynecologic Cancer Society, Education Committee
01/2000-12/2004PresidentHong Kong Society of Colposcopy and Cervical Pathology
2003-2014Regional council memberInternational Planned Parenthood Federation
2008-2014Regional Exexutive Committee memberInternational Planned Parenthood Federation
01/2003-12/2003MemberCouncil of the Hong Kong College of Obstetricians and Gynaecologists
01/2007-12/2009ChairmanQuality Assurance Committee of the Hong Kong College of Obstetricians and Gynaecologists
01/2000-12/2006ChairmanInternational Federation of Gynecology and Obstetrics, Gynecological Oncology Committee
01/2007-12/2009MemberInternational Federation of Gynecology and Obstetrics, Gynecological Oncology Committee
1/2/2013-30/9/2016MemberGrant Review Board (Health and Medical Research Fund, Food & Health Bureau)
2005-2009HK representativeAsia Oceania Research Organization on Genital Infectious & Neoplasia (AOGIN)
01/2002-12/2007MemberEducation Committee of the Hong Kong College of Obstetricians and Gynaecologists
01/2007-MemberFellowship Selection Committee of the Hong Kong College of Obstetricians and Gynaecologists
01/2006-12/2007MemberSubspecialty Committee of the Hong Kong College of Obstetricians and Gynaecologists
2010-Vice-PresidentAsian Gynecologic Oncology Group (AGOG)
2001-2004, 2004-2007, 2007-2010, 2010-2012, 2012-presentUICC TNM Expert Advisory Panel on Gynaecologic Cancer
2009-Honorary MemberThe Society for Colposcopy & Cervical Pathology of Singapore
01/2002-12/2002MemberExperts Nominated by Council under Gynaecological Oncology of the Hong Kong College of Obstetricians and Gynaecologists
1/8/2012-ChairmanClinical Work Group for Women’s Services, HKWC
01/2006-ChairAsian Gynecologic Cancer Group, Protocol Review Committee
01/2002-12/2002&01/2004-12/2005MemberGynaecological Oncology Subspecialty Board of the Hong Kong College of Obstetricians and Gynaecologists
2013-Founding member, Council MemberThe Hong Kong Society of Robotic Surgery
2009-Council MemeberAsian Society of Gynecologic Oncology (ASGO)
2002-2006MemberTNM Prognostic Factor Core Group on TNM Project, UICC
2005ChairmanProtocol Review Committee of Asian Gynecologic Oncology Group
2008-2009Member of Scientific CommitteeFIGO XIX World Congress of Gynecology and Obstetrics
2012-2015MemberFIGO Subcommittee on Cervical Cancer
01/2005-12/2007MemberContinuous Professional Development Sub-committee of the Hong Kong College of Obstetricians and Gynaecologists
2010-MemberThe National TNM Cancer Staging Committee of China
2008-2010President-electAsia Oceania research organization on Genital Infections and Neoplasia (AOGIN)
2010-2012PresidentAsia Oceania research organization on Genital Infections and Neoplasia (AOGIN)
01/2003-6/2015MemberInternship Sub-committee, the Licentiate Committee of the Medical Council of Hong Kong
01/2005-12/2008ChairGynaecological Oncology Board of the Hong Kong College of Obstetricians and Gynaecologists
2005Founding memberAsian Gynecologic Oncology Group
2010-2012Member of Scientific CommitteeThe 14th Biennial Meeting of the International Gynecologic Cancer Society
01/2002-12/2002MemberStructured Oral Examination Sub-committee of the Hong Kong College of Obstetricians and Gynaecologists
1/10/2013-31/7/2018ChairmanCredentialing Committee, HKWC
01/2004-12/2007MemberFinance and Executive Committee of the Hong Kong College of Obstetricians and Gynaecologists
2010-2012Chair of Organizing CommitteeAOGIN 2012 Conference
01/2004-12/2006College representativeEducation Committee, Hong Kong Academy of Medicine
01/2002-12/2004MemberManpower and Subspecialty Committee of the Hong Kong College of Obstetricians and Gynaecologists
2010-2012PresidentThe Hong Kong College of Obstetricians and Gynaecologists
2014Co-opted Member to CouncilThe Hong Kong College of Obstetricians and Gynaecologists
2011-2014Regional Exexutive Committee memberInternational Planned Parenthood Federation
2009-2010Member of Scientific CommitteeThe 13th Biennial Meeting of the International Gynecologic Cancer Society
01/1998-12/2006MemberQuality Assurance Committee of the Hong Kong College of Obstetricians and Gynaecologists
01/2005-Board memberAsia Oceania research organization of Genital Infections & Neoplasia (AOGIN)
2007-2009MemberFIGO Working Group on Combating Cervical Cancer
01/2002-12/2002&01/2005-12/2006MemberManpower Committee of the Hong Kong College of Obstetricians and Gynaecologists
2012-2014Member of Scientific CommitteeThe 15th Biennial Meeting of the International Gynecologic Cancer Society
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