File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Apoptotic activity in gestational trophoblastic disease correlates with clinical outcome: Assessment by the caspase-related M30 CytoDeath antibody

TitleApoptotic activity in gestational trophoblastic disease correlates with clinical outcome: Assessment by the caspase-related M30 CytoDeath antibody
Authors
KeywordsApoptosis
Caspase
Gestational trophoblastic disease
M30
Issue Date2001
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 2001, v. 38 n. 3, p. 243-249 How to Cite?
AbstractAims: The objective of this study was to assess apoptotic activity in gestational trophoblastic disease (GTD) and its prognostic value in hydatidiform mole (HM). Methods and results: Expression of the specific caspase cleavage site within cytokeratin 18 was assessed immunohistochemically using the monoclonal antibody M30 CytoDeath in 12 spontaneous abortions, 22 partial and 57 complete HM, eight choriocarcinoma (CCA) and 28 normal placentas. The M30 immunoreactivity occurred predominantly in the syncytiotrophoblasts. A significantly higher M30 index in HM and CCA was found when compared with normal placentas and spontaneous abortions (P < 0.001). The M30 index of those HM which spontaneously regressed was significantly higher than those HM which developed persistent disease requiring chemotherapy (P < 0.001). The M30 index correlated with another apoptotic index previously detected by TdT-mediated dUTP nick-end labelling (TUNEL) (P = 0.007) and the proliferation index assessed by the Ki67 antigen (P = 0.034). Conclusions: We conclude that apoptosis is important in the pathogenesis of GTD. Assessment of apoptotic activity in HM by the M30 index may be considered as an alternative prognostic indicator for predicting the clinical behaviour.
Persistent Identifierhttp://hdl.handle.net/10722/87203
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChiu, PMen_HK
dc.contributor.authorNgan, YSen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T09:26:39Z-
dc.date.available2010-09-06T09:26:39Z-
dc.date.issued2001en_HK
dc.identifier.citationHistopathology, 2001, v. 38 n. 3, p. 243-249en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87203-
dc.description.abstractAims: The objective of this study was to assess apoptotic activity in gestational trophoblastic disease (GTD) and its prognostic value in hydatidiform mole (HM). Methods and results: Expression of the specific caspase cleavage site within cytokeratin 18 was assessed immunohistochemically using the monoclonal antibody M30 CytoDeath in 12 spontaneous abortions, 22 partial and 57 complete HM, eight choriocarcinoma (CCA) and 28 normal placentas. The M30 immunoreactivity occurred predominantly in the syncytiotrophoblasts. A significantly higher M30 index in HM and CCA was found when compared with normal placentas and spontaneous abortions (P < 0.001). The M30 index of those HM which spontaneously regressed was significantly higher than those HM which developed persistent disease requiring chemotherapy (P < 0.001). The M30 index correlated with another apoptotic index previously detected by TdT-mediated dUTP nick-end labelling (TUNEL) (P = 0.007) and the proliferation index assessed by the Ki67 antigen (P = 0.034). Conclusions: We conclude that apoptosis is important in the pathogenesis of GTD. Assessment of apoptotic activity in HM by the M30 index may be considered as an alternative prognostic indicator for predicting the clinical behaviour.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectApoptosisen_HK
dc.subjectCaspaseen_HK
dc.subjectGestational trophoblastic diseaseen_HK
dc.subjectM30en_HK
dc.subject.meshAbortion, Spontaneous - metabolismen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCaspases - metabolismen_HK
dc.subject.meshChoriocarcinoma - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHumansen_HK
dc.subject.meshHydatidiform Mole - metabolism - pathologyen_HK
dc.subject.meshIn Situ Nick-End Labelingen_HK
dc.subject.meshKeratins - metabolismen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshTrophoblastic Neoplasms - metabolism - pathologyen_HK
dc.subject.meshTrophoblastic Tumor, Placental Site - metabolism - pathologyen_HK
dc.subject.meshUterine Neoplasms - metabolism - pathologyen_HK
dc.titleApoptotic activity in gestational trophoblastic disease correlates with clinical outcome: Assessment by the caspase-related M30 CytoDeath antibodyen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=38&issue=3&spage=243&epage=249&date=2001&atitle=Apoptotic+activity+in+gestational+trophoblastic+disease+correlates+with+clinical+outcome:+assessment+by+the+caspase-related+M30+CytoDeath+antibodyen_HK
dc.identifier.emailNgan, YS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityNgan, YS=rp00346en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1046/j.1365-2559.2001.01065.xen_HK
dc.identifier.pmid11260306-
dc.identifier.scopuseid_2-s2.0-0034818856en_HK
dc.identifier.hkuros63781en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0034818856&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume38en_HK
dc.identifier.issue3en_HK
dc.identifier.spage243en_HK
dc.identifier.epage249en_HK
dc.identifier.isiWOS:000168050000010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChiu, PM=7103182596en_HK
dc.identifier.scopusauthoridNgan, YS=34571944100en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats