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Article: Proliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix

TitleProliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervix
Authors
KeywordsAdenocarcinoma
AIS
MI/AI ratio
Issue Date2004
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 2004, v. 92 n. 3, p. 866-872 How to Cite?
AbstractObjectives. To determine the Mitotic Index (MI), Apoptotic Index (AI), the ratio of the two indices (MI/AI) in normal endocervical glands, adenocarcinoma in situ (AIS) and invasive adenocarcinoma of cervix, and to evaluate the relationship among these indices with various clinicopathological features. Methods. The MI, AI and MI/AI ratio in cervical adenocarcinoma were evaluated based on: (1) cell morphology in hematoxylin and eosin-stained sections; (2) immunohistochemical study for Ki67 antigen and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL). Eighty cases of invasive adenocarcinoma and eighteen cases of adenocarcinoma in situ (AIS) adjacent to invasive adenocarcinoma were included. Adjacent normal endocervical epithelium in 26 cases of adenocarcinoma was included as control. Results. The MI, AI and MI/AI in normal endocervical glands, AIS and invasive carcinomas showed statistically significant differences (P < 0.001). A significant positive correlation was found between AI and MI, as assessed by morphological features (P < 0.001) and immunohistochemistry (P = 0.006). The MI/AI ratio, determined by morphology, significantly correlated with staging (P = 0.023) and survival (P = 0.0045). Multivariate survival analysis showed that both MI/AI ratio determined by morphology (P < 0.001) and stage of tumor (P = 0.03) had independent prognostic value in invasive adenocarcinoma. Conclusions. Tumor proliferation significantly correlated with apoptotic activity in cervical adenocarcinoma. The MI/AI ratio was an independent prognostic factor associated with patient survival. Histological determination of MI/AI ratio proved to be an economical and potentially useful adjunct in predicting clinical outcome of patients with cervical adenocarcinoma. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/87079
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLeung, TWen_HK
dc.contributor.authorXue, WCen_HK
dc.contributor.authorCheung, ANYen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorNgan, HYSen_HK
dc.date.accessioned2010-09-06T09:25:03Z-
dc.date.available2010-09-06T09:25:03Z-
dc.date.issued2004en_HK
dc.identifier.citationGynecologic Oncology, 2004, v. 92 n. 3, p. 866-872en_HK
dc.identifier.issn0090-8258en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87079-
dc.description.abstractObjectives. To determine the Mitotic Index (MI), Apoptotic Index (AI), the ratio of the two indices (MI/AI) in normal endocervical glands, adenocarcinoma in situ (AIS) and invasive adenocarcinoma of cervix, and to evaluate the relationship among these indices with various clinicopathological features. Methods. The MI, AI and MI/AI ratio in cervical adenocarcinoma were evaluated based on: (1) cell morphology in hematoxylin and eosin-stained sections; (2) immunohistochemical study for Ki67 antigen and terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labeling (TUNEL). Eighty cases of invasive adenocarcinoma and eighteen cases of adenocarcinoma in situ (AIS) adjacent to invasive adenocarcinoma were included. Adjacent normal endocervical epithelium in 26 cases of adenocarcinoma was included as control. Results. The MI, AI and MI/AI in normal endocervical glands, AIS and invasive carcinomas showed statistically significant differences (P < 0.001). A significant positive correlation was found between AI and MI, as assessed by morphological features (P < 0.001) and immunohistochemistry (P = 0.006). The MI/AI ratio, determined by morphology, significantly correlated with staging (P = 0.023) and survival (P = 0.0045). Multivariate survival analysis showed that both MI/AI ratio determined by morphology (P < 0.001) and stage of tumor (P = 0.03) had independent prognostic value in invasive adenocarcinoma. Conclusions. Tumor proliferation significantly correlated with apoptotic activity in cervical adenocarcinoma. The MI/AI ratio was an independent prognostic factor associated with patient survival. Histological determination of MI/AI ratio proved to be an economical and potentially useful adjunct in predicting clinical outcome of patients with cervical adenocarcinoma. © 2004 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_HK
dc.relation.ispartofGynecologic Oncologyen_HK
dc.subjectAdenocarcinomaen_HK
dc.subjectAISen_HK
dc.subjectMI/AI ratioen_HK
dc.subject.meshAdenocarcinoma - pathologyen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshApoptosisen_HK
dc.subject.meshCarcinoma in Situ - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMitotic Indexen_HK
dc.subject.meshNeoplasm Invasivenessen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshUterine Cervical Neoplasms - pathologyen_HK
dc.titleProliferation to apoptosis ratio as a prognostic marker in adenocarcinoma of uterine cervixen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0090-8258&volume=92&issue=3&spage=866&epage=872 &date=2004&atitle=Proliferation+to+apoptosis+ratio+as+a+prognostic+marker+in+adenocarcinoma+of+uterine+cervixen_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ygyno.2003.11.051en_HK
dc.identifier.pmid14984954-
dc.identifier.scopuseid_2-s2.0-1342300677en_HK
dc.identifier.hkuros86854en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-1342300677&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue3en_HK
dc.identifier.spage866en_HK
dc.identifier.epage872en_HK
dc.identifier.isiWOS:000220057700021-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, TW=7202110195en_HK
dc.identifier.scopusauthoridXue, WC=7103165268en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK

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