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Article: Replicative MCM7 protein as a proliferation marker in endometrial carcinoma: A tissue microarray and clinicopathological analysis

TitleReplicative MCM7 protein as a proliferation marker in endometrial carcinoma: A tissue microarray and clinicopathological analysis
Authors
KeywordsEndometrial carcinoma
Ki67
Minichromosome maintenance protein 7 (MCM7)
Prognosis
Proliferation
Tissue microarray
Issue Date2005
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HIS
Citation
Histopathology, 2005, v. 46 n. 3, p. 307-313 How to Cite?
AbstractAims: To assess, in tissue microarray (TMA), the proliferative activity of endometrial carcinoma using one of the minichromosome maintenance (MCM) proteins (MCM7), and to explore its potential value for prognosis. MCM proteins are essential for eukaryotic DNA replication and have recently been used to define the proliferative compartments in human tissues. Methods and results: Immunohistochemistry for MCM7 and Ki67 was performed on TMAs constructed from 212 cases of endometrial carcinoma. MCM7 and Ki67 expression was quantified according to the extent of nuclear staining. An analysis was carried out of the association between MCM7 expression and that of Ki67 and the clinicopathological characteristics of endometrial carcinoma. MCM7 and Ki67 immunoreactivity was clearly evident in the nuclei of tumour cells. MCM7 and Ki67 labelling indices in endometrial carcinomas correlated with each other (P < 0.001). A significant correlation existed between the MCM7 labelling index and histological grade (P = 0.008) and patients' age at diagnosis (P < 0.001). Well-differentiated carcinomas and younger patients had a lower MCM7 index. Poor survival was observed in patients with endometrial carcinoma with a high MCM7 index (P = 0.03) and MCM7 was found to be an independent prognostic factor by multivariate analysis (P = 0.04). The Ki67 labelling index correlated with histological grade (P = 0.01) but had no significant prognostic impact (P = 0.50). Conclusions: In this TMA study on endometrial carcinoma, MCM7 was found to be a more reliable and useful marker than Ki67 in assessing tumour proliferation and in the prognosis of patients. © 2005 Blackwell Publishing Limited.
Persistent Identifierhttp://hdl.handle.net/10722/87030
ISSN
2015 Impact Factor: 3.425
2015 SCImago Journal Rankings: 1.488
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, SSen_HK
dc.contributor.authorXue, WCen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorChan, KYKen_HK
dc.contributor.authorTam, IYSen_HK
dc.contributor.authorChiu, PMen_HK
dc.contributor.authorIp, PPCen_HK
dc.contributor.authorTam, KFen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T09:24:24Z-
dc.date.available2010-09-06T09:24:24Z-
dc.date.issued2005en_HK
dc.identifier.citationHistopathology, 2005, v. 46 n. 3, p. 307-313en_HK
dc.identifier.issn0309-0167en_HK
dc.identifier.urihttp://hdl.handle.net/10722/87030-
dc.description.abstractAims: To assess, in tissue microarray (TMA), the proliferative activity of endometrial carcinoma using one of the minichromosome maintenance (MCM) proteins (MCM7), and to explore its potential value for prognosis. MCM proteins are essential for eukaryotic DNA replication and have recently been used to define the proliferative compartments in human tissues. Methods and results: Immunohistochemistry for MCM7 and Ki67 was performed on TMAs constructed from 212 cases of endometrial carcinoma. MCM7 and Ki67 expression was quantified according to the extent of nuclear staining. An analysis was carried out of the association between MCM7 expression and that of Ki67 and the clinicopathological characteristics of endometrial carcinoma. MCM7 and Ki67 immunoreactivity was clearly evident in the nuclei of tumour cells. MCM7 and Ki67 labelling indices in endometrial carcinomas correlated with each other (P < 0.001). A significant correlation existed between the MCM7 labelling index and histological grade (P = 0.008) and patients' age at diagnosis (P < 0.001). Well-differentiated carcinomas and younger patients had a lower MCM7 index. Poor survival was observed in patients with endometrial carcinoma with a high MCM7 index (P = 0.03) and MCM7 was found to be an independent prognostic factor by multivariate analysis (P = 0.04). The Ki67 labelling index correlated with histological grade (P = 0.01) but had no significant prognostic impact (P = 0.50). Conclusions: In this TMA study on endometrial carcinoma, MCM7 was found to be a more reliable and useful marker than Ki67 in assessing tumour proliferation and in the prognosis of patients. © 2005 Blackwell Publishing Limited.en_HK
dc.languageengen_HK
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/HISen_HK
dc.relation.ispartofHistopathologyen_HK
dc.rightsHistopathology. Copyright © Blackwell Publishing Ltd.en_HK
dc.subjectEndometrial carcinomaen_HK
dc.subjectKi67en_HK
dc.subjectMinichromosome maintenance protein 7 (MCM7)en_HK
dc.subjectPrognosisen_HK
dc.subjectProliferationen_HK
dc.subjectTissue microarrayen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAged, 80 and overen_HK
dc.subject.meshCell Cycle Proteins - analysisen_HK
dc.subject.meshCell Proliferationen_HK
dc.subject.meshDNA Replicationen_HK
dc.subject.meshDNA-Binding Proteins - analysisen_HK
dc.subject.meshEndometrial Neoplasms - metabolism - pathologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunohistochemistryen_HK
dc.subject.meshKi-67 Antigen - analysisen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshMultivariate Analysisen_HK
dc.subject.meshNeoplasm Stagingen_HK
dc.subject.meshNuclear Proteins - analysisen_HK
dc.subject.meshPrognosisen_HK
dc.subject.meshSurvival Analysisen_HK
dc.subject.meshTissue Array Analysisen_HK
dc.subject.meshTumor Markers, Biological - analysisen_HK
dc.titleReplicative MCM7 protein as a proliferation marker in endometrial carcinoma: A tissue microarray and clinicopathological analysisen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0309-0167&volume=46&issue=3&spage=307&epage=313&date=2005&atitle=Replicative+MCM7+protein+as+a+proliferation+marker+in+endometrial+carcinoma:+A+tissue+microarray+and+clinicopathological+analysisen_HK
dc.identifier.emailKhoo, US: uskhoo@hku.hken_HK
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_HK
dc.identifier.emailChan, KYK: kelvinc@pathology.hku.hken_HK
dc.identifier.emailCheung, ANY: anycheun@hkucc.hku.hken_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityChan, KYK=rp00453en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1365-2559.2005.02069.xen_HK
dc.identifier.pmid15720416-
dc.identifier.scopuseid_2-s2.0-20044364352en_HK
dc.identifier.hkuros102353en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20044364352&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume46en_HK
dc.identifier.issue3en_HK
dc.identifier.spage307en_HK
dc.identifier.epage313en_HK
dc.identifier.isiWOS:000227133900007-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLi, SS=14834253300en_HK
dc.identifier.scopusauthoridXue, WC=7103165268en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridChan, KYK=7406034195en_HK
dc.identifier.scopusauthoridTam, IYS=8244035800en_HK
dc.identifier.scopusauthoridChiu, PM=7103182596en_HK
dc.identifier.scopusauthoridIp, PPC=7003622683en_HK
dc.identifier.scopusauthoridTam, KF=7201692816en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK
dc.identifier.citeulike99287-

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