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Article: Small-for-size liver graft injury-impact on tumor behavior

TitleSmall-for-size liver graft injury-impact on tumor behavior
Authors
KeywordsMedical sciences
Surgery
Issue Date2010
PublisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/trre
Citation
Transplantation Reviews, 2010, v. 24 n. 1, p. 1-10 How to Cite?
AbstractThe success of liver transplantation has led to an ever-increasing demand for liver grafts. Since the first successful living donor liver transplantation, this surgical innovation has been well established in children and has significantly relieved the crisis of donor organ shortage for children. However, the extension of living donor liver transplantation to adult recipients is limited by the graft volume. The major concern of adult-to-adult living donor liver transplantation is the adequate graft that can be harvested from a living donor. Small-for-size graft injury is frequently observed. To develop novel effective treatments attenuating small-for-size liver graft injury during living donor liver transplantation, it is important to explore the precise mechanism of acute phase small-for-size graft damage. Recently, a number of clinical studies and animal experiments have been conducted to investigate the possible key issues on acute phase small-for-size liver graft injury, such as mechanical injury from shear stress, subsequent inflammatory responses, and imbalance of vasoregulatory factors. This review focuses on the mechanism of small-for-size liver graft injury based on the number of clinical and experimental studies. The latest research findings of the significance of acute phase liver graft injury on late phase tumor recurrence and metastasis are also addressed. © 2010 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/83815
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.977
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorShih, KCen_HK
dc.contributor.authorMan, Ken_HK
dc.date.accessioned2010-09-06T08:45:33Z-
dc.date.available2010-09-06T08:45:33Z-
dc.date.issued2010en_HK
dc.identifier.citationTransplantation Reviews, 2010, v. 24 n. 1, p. 1-10en_HK
dc.identifier.issn0955-470Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/83815-
dc.description.abstractThe success of liver transplantation has led to an ever-increasing demand for liver grafts. Since the first successful living donor liver transplantation, this surgical innovation has been well established in children and has significantly relieved the crisis of donor organ shortage for children. However, the extension of living donor liver transplantation to adult recipients is limited by the graft volume. The major concern of adult-to-adult living donor liver transplantation is the adequate graft that can be harvested from a living donor. Small-for-size graft injury is frequently observed. To develop novel effective treatments attenuating small-for-size liver graft injury during living donor liver transplantation, it is important to explore the precise mechanism of acute phase small-for-size graft damage. Recently, a number of clinical studies and animal experiments have been conducted to investigate the possible key issues on acute phase small-for-size liver graft injury, such as mechanical injury from shear stress, subsequent inflammatory responses, and imbalance of vasoregulatory factors. This review focuses on the mechanism of small-for-size liver graft injury based on the number of clinical and experimental studies. The latest research findings of the significance of acute phase liver graft injury on late phase tumor recurrence and metastasis are also addressed. © 2010 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherWB Saunders Co. The Journal's web site is located at http://www.elsevier.com/locate/trreen_HK
dc.relation.ispartofTransplantation Reviewsen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectMedical sciences-
dc.subjectSurgery-
dc.titleSmall-for-size liver graft injury-impact on tumor behavioren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0955-470X&volume=24&issue=1&spage=1&epage=10&date=2010&atitle=Small-for-size+liver+graft+injury--impact+on+tumor+behavioren_HK
dc.identifier.emailShih, KC: kcshih@hku.hken_HK
dc.identifier.emailMan, K: kwanman@hku.hken_HK
dc.identifier.authorityShih, KC=rp01374en_HK
dc.identifier.authorityMan, K=rp00417en_HK
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.trre.2009.06.004en_HK
dc.identifier.pmid19828306en_HK
dc.identifier.scopuseid_2-s2.0-70449701469en_HK
dc.identifier.hkuros168584en_HK
dc.identifier.hkuros170184-
dc.identifier.hkuros184056-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70449701469&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume24en_HK
dc.identifier.issue1en_HK
dc.identifier.spage1en_HK
dc.identifier.epage10en_HK
dc.identifier.isiWOS:000208605700001-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridShih, KC=35765776400en_HK
dc.identifier.scopusauthoridMan, K=7101754072en_HK

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