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Article: Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B

TitleSignificance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B
Authors
Issue Date2004
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.html
Citation
American Journal Of Gastroenterology, 2004, v. 99 n. 10, p. 2032-2037 How to Cite?
AbstractOBJECTIVE: To determine the relationship between hepatitis B virus (HBV) DNA levels and total histologic activity index (HAI), necroinflammation (HAI-NI), and fibrosis (HAI-F) scores. PATIENTS AND Liver histology and HBV DNA levels were determined in 94 patients with chronic METHODS: hepatitis B. RESULTS: There was no association between HBV DNA levels and liver histology in hepatitis-B-e antigen-positive patients (n = 43). In anti-HBe-positive patients (n = 51), HBV DNA levels correlated positively with HAI-NI (r = 0.31, p = 0.014) and HAI-F (r = 0.33, p = 0.017) scores. Though the majority of anti-HBe-positive patients with HBV DNA levels <105 copies/ml had mild necroinflammation and no fibrosis, 14.3% had established fibrosis. Anti-HBe-positive patients with core promoter mutations had a poorer histology compared to those without. There was no difference in the histology between anti-HBe-positive patients with and without precore mutations. Alanine aminotransferase (ALT) level correlated positively with HAI-NI score. Patients with persistently normal ALT levels had a significantly lower median HAI-NI score compared to patients with either persistently or intermittently elevated ALT levels. CONCLUSIONS: In anti-HBe-positive patients, though HBV DNA level <105 copies/ml was associated with better histology, 14.3% patients had established fibrosis. Further studies to define a better cut-off HBV DNA level to differentiate low- and high-risk patients for disease progression are required.
Persistent Identifierhttp://hdl.handle.net/10722/78679
ISSN
2015 Impact Factor: 10.383
2015 SCImago Journal Rankings: 3.946
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorFan, STen_HK
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorYuen, JCHen_HK
dc.contributor.authorSum, SSMen_HK
dc.contributor.authorChan, AOOen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:45:32Z-
dc.date.available2010-09-06T07:45:32Z-
dc.date.issued2004en_HK
dc.identifier.citationAmerican Journal Of Gastroenterology, 2004, v. 99 n. 10, p. 2032-2037en_HK
dc.identifier.issn0002-9270en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78679-
dc.description.abstractOBJECTIVE: To determine the relationship between hepatitis B virus (HBV) DNA levels and total histologic activity index (HAI), necroinflammation (HAI-NI), and fibrosis (HAI-F) scores. PATIENTS AND Liver histology and HBV DNA levels were determined in 94 patients with chronic METHODS: hepatitis B. RESULTS: There was no association between HBV DNA levels and liver histology in hepatitis-B-e antigen-positive patients (n = 43). In anti-HBe-positive patients (n = 51), HBV DNA levels correlated positively with HAI-NI (r = 0.31, p = 0.014) and HAI-F (r = 0.33, p = 0.017) scores. Though the majority of anti-HBe-positive patients with HBV DNA levels <105 copies/ml had mild necroinflammation and no fibrosis, 14.3% had established fibrosis. Anti-HBe-positive patients with core promoter mutations had a poorer histology compared to those without. There was no difference in the histology between anti-HBe-positive patients with and without precore mutations. Alanine aminotransferase (ALT) level correlated positively with HAI-NI score. Patients with persistently normal ALT levels had a significantly lower median HAI-NI score compared to patients with either persistently or intermittently elevated ALT levels. CONCLUSIONS: In anti-HBe-positive patients, though HBV DNA level <105 copies/ml was associated with better histology, 14.3% patients had established fibrosis. Further studies to define a better cut-off HBV DNA level to differentiate low- and high-risk patients for disease progression are required.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/ajg/index.htmlen_HK
dc.relation.ispartofAmerican Journal of Gastroenterologyen_HK
dc.subject.meshAdolescenten_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAlanine Transaminase - analysisen_HK
dc.subject.meshDNA, Viral - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHepatitis B e Antigens - blooden_HK
dc.subject.meshHepatitis B virus - geneticsen_HK
dc.subject.meshHepatitis B, Chronic - blood - pathology - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - chemistry - pathologyen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.titleSignificance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis Ben_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0002-9270&volume=99&issue=10&spage=2032&epage=2037&date=2004&atitle=Significance+of+HBV+DNA+levels+in+liver+histology+of+HBeAg+and+anti-HBe+positive+patients+with+chronic+hepatitis+Ben_HK
dc.identifier.emailYuen, MF: mfyuen@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL: iolng@hkucc.hku.hken_HK
dc.identifier.emailFan, ST: stfan@hku.hken_HK
dc.identifier.emailWong, DKH: danywong@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityFan, ST=rp00355en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1572-0241.2004.40440.xen_HK
dc.identifier.pmid15447768-
dc.identifier.scopuseid_2-s2.0-7044241297en_HK
dc.identifier.hkuros94873en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-7044241297&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue10en_HK
dc.identifier.spage2032en_HK
dc.identifier.epage2037en_HK
dc.identifier.isiWOS:000224403900034-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridFan, ST=7402678224en_HK
dc.identifier.scopusauthoridYuan, HJ=7402446707en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridYuen, JCH=7102620480en_HK
dc.identifier.scopusauthoridSum, SSM=6603889128en_HK
dc.identifier.scopusauthoridChan, AOO=7403167965en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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