File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1093/qjmed/92.7.401
- Scopus: eid_2-s2.0-0032806194
- PMID: 10627890
- WOS: WOS:000081627600007
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients
Title | Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients |
---|---|
Authors | |
Issue Date | 1999 |
Publisher | Oxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/ |
Citation | Qjm - Monthly Journal Of The Association Of Physicians, 1999, v. 92 n. 7, p. 401-406 How to Cite? |
Abstract | We retrospectively studied the clinical course and treatment outcome of idiopathic membranous nephropathy (IMN) amongst 38 Chinese patients (25 male, 13 female, age 51.6 ± 14.6 years, follow-up duration 58.2 ± 51.1 months) who presented over a 10-year review period. Eight never received any form of specific treatment (group I), seven received oral corticosteroid alone for 6-9 months (group II), 17 were given corticosteroid plus cyclophosphamide for 6-12 months (group III), and six were treated with methylprednisolone alternating with chlorambucil every other month for 6 months (group IV). No untoward effect from drugs sufficient to alter the dosage used was recorded. After 6 months of treatment, over 50% of patients went into remission: a significant reduction in proteinuria (p = 0.01, 0.01, 0.02) with a corresponding rise in serum albumin levels (p = 0.01, 0.01, 0.04) was observed in groups II, III, and IV, respectively, but not in group I. During follow-up, one patient in each of groups I, III, IV, and two of group II developed renal function deterioration, which correlated with an abnormal presenting serum creatinine. In six group I and eight group III patients who have been followed for at least 5 years, there was progressive reduction in proteinuria in group III (p < 0.05), but not in group I: serum creatinine has remained unchanged in both groups. IMN runs a benign course in Chinese patients in Hong Kong, with 2.6% of patients going into end-stage renal failure during the study period. Contrary to reports in Caucasians, there is similar treatment response to steroid alone or a combination of steroid and cytotoxic agents. |
Persistent Identifier | http://hdl.handle.net/10722/78535 |
ISSN | |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Tang, S | en_HK |
dc.contributor.author | Chan, TM | en_HK |
dc.contributor.author | Cheng, IKP | en_HK |
dc.contributor.author | Lai, KN | en_HK |
dc.date.accessioned | 2010-09-06T07:43:57Z | - |
dc.date.available | 2010-09-06T07:43:57Z | - |
dc.date.issued | 1999 | en_HK |
dc.identifier.citation | Qjm - Monthly Journal Of The Association Of Physicians, 1999, v. 92 n. 7, p. 401-406 | en_HK |
dc.identifier.issn | 0033-5622 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/78535 | - |
dc.description.abstract | We retrospectively studied the clinical course and treatment outcome of idiopathic membranous nephropathy (IMN) amongst 38 Chinese patients (25 male, 13 female, age 51.6 ± 14.6 years, follow-up duration 58.2 ± 51.1 months) who presented over a 10-year review period. Eight never received any form of specific treatment (group I), seven received oral corticosteroid alone for 6-9 months (group II), 17 were given corticosteroid plus cyclophosphamide for 6-12 months (group III), and six were treated with methylprednisolone alternating with chlorambucil every other month for 6 months (group IV). No untoward effect from drugs sufficient to alter the dosage used was recorded. After 6 months of treatment, over 50% of patients went into remission: a significant reduction in proteinuria (p = 0.01, 0.01, 0.02) with a corresponding rise in serum albumin levels (p = 0.01, 0.01, 0.04) was observed in groups II, III, and IV, respectively, but not in group I. During follow-up, one patient in each of groups I, III, IV, and two of group II developed renal function deterioration, which correlated with an abnormal presenting serum creatinine. In six group I and eight group III patients who have been followed for at least 5 years, there was progressive reduction in proteinuria in group III (p < 0.05), but not in group I: serum creatinine has remained unchanged in both groups. IMN runs a benign course in Chinese patients in Hong Kong, with 2.6% of patients going into end-stage renal failure during the study period. Contrary to reports in Caucasians, there is similar treatment response to steroid alone or a combination of steroid and cytotoxic agents. | en_HK |
dc.language | eng | en_HK |
dc.publisher | Oxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/ | en_HK |
dc.relation.ispartof | QJM - Monthly Journal of the Association of Physicians | en_HK |
dc.rights | Q J M. Copyright © Oxford University Press. | en_HK |
dc.subject.mesh | Aged | en_HK |
dc.subject.mesh | Antihypertensive Agents - therapeutic use | en_HK |
dc.subject.mesh | Chlorambucil - therapeutic use | en_HK |
dc.subject.mesh | Creatinine - blood | en_HK |
dc.subject.mesh | Cyclophosphamide - therapeutic use | en_HK |
dc.subject.mesh | Drug Therapy, Combination | en_HK |
dc.subject.mesh | Female | en_HK |
dc.subject.mesh | Follow-Up Studies | en_HK |
dc.subject.mesh | Glomerulonephritis, Membranous - drug therapy - ethnology - metabolism | en_HK |
dc.subject.mesh | Glucocorticoids - therapeutic use | en_HK |
dc.subject.mesh | Hong Kong - ethnology | en_HK |
dc.subject.mesh | Humans | en_HK |
dc.subject.mesh | Immunosuppressive Agents - therapeutic use | en_HK |
dc.subject.mesh | Male | en_HK |
dc.subject.mesh | Middle Aged | en_HK |
dc.subject.mesh | Prednisolone - therapeutic use | en_HK |
dc.subject.mesh | Proteinuria - metabolism | en_HK |
dc.subject.mesh | Retrospective Studies | en_HK |
dc.subject.mesh | Serum Albumin - analysis | en_HK |
dc.title | Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients | en_HK |
dc.type | Article | en_HK |
dc.identifier.openurl | http://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1460-2725&volume=92&spage=401&epage=406&date=1999&atitle=Clinical+features+and+treatment+outcome+of+idiopathic+membranous+nephropathy+in+Chinese+patients | en_HK |
dc.identifier.email | Tang, S: scwtang@hku.hk | en_HK |
dc.identifier.email | Chan, TM: dtmchan@hku.hk | en_HK |
dc.identifier.email | Lai, KN: knlai@hku.hk | en_HK |
dc.identifier.authority | Tang, S=rp00480 | en_HK |
dc.identifier.authority | Chan, TM=rp00394 | en_HK |
dc.identifier.authority | Lai, KN=rp00324 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1093/qjmed/92.7.401 | - |
dc.identifier.pmid | 10627890 | - |
dc.identifier.scopus | eid_2-s2.0-0032806194 | en_HK |
dc.identifier.hkuros | 49781 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0032806194&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 92 | en_HK |
dc.identifier.issue | 7 | en_HK |
dc.identifier.spage | 401 | en_HK |
dc.identifier.epage | 406 | en_HK |
dc.identifier.isi | WOS:000081627600007 | - |
dc.identifier.scopusauthorid | Tang, S=7403437082 | en_HK |
dc.identifier.scopusauthorid | Chan, TM=7402687700 | en_HK |
dc.identifier.scopusauthorid | Cheng, IKP=7102537483 | en_HK |
dc.identifier.scopusauthorid | Lai, KN=7402135706 | en_HK |
dc.identifier.issnl | 0033-5622 | - |