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Article: Clinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients

TitleClinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patients
Authors
Issue Date1999
PublisherOxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/
Citation
Qjm - Monthly Journal Of The Association Of Physicians, 1999, v. 92 n. 7, p. 401-406 How to Cite?
AbstractWe retrospectively studied the clinical course and treatment outcome of idiopathic membranous nephropathy (IMN) amongst 38 Chinese patients (25 male, 13 female, age 51.6 ± 14.6 years, follow-up duration 58.2 ± 51.1 months) who presented over a 10-year review period. Eight never received any form of specific treatment (group I), seven received oral corticosteroid alone for 6-9 months (group II), 17 were given corticosteroid plus cyclophosphamide for 6-12 months (group III), and six were treated with methylprednisolone alternating with chlorambucil every other month for 6 months (group IV). No untoward effect from drugs sufficient to alter the dosage used was recorded. After 6 months of treatment, over 50% of patients went into remission: a significant reduction in proteinuria (p = 0.01, 0.01, 0.02) with a corresponding rise in serum albumin levels (p = 0.01, 0.01, 0.04) was observed in groups II, III, and IV, respectively, but not in group I. During follow-up, one patient in each of groups I, III, IV, and two of group II developed renal function deterioration, which correlated with an abnormal presenting serum creatinine. In six group I and eight group III patients who have been followed for at least 5 years, there was progressive reduction in proteinuria in group III (p < 0.05), but not in group I: serum creatinine has remained unchanged in both groups. IMN runs a benign course in Chinese patients in Hong Kong, with 2.6% of patients going into end-stage renal failure during the study period. Contrary to reports in Caucasians, there is similar treatment response to steroid alone or a combination of steroid and cytotoxic agents.
Persistent Identifierhttp://hdl.handle.net/10722/78535
ISSN
1998 Impact Factor: 2.244
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTang, Sen_HK
dc.contributor.authorChan, TMen_HK
dc.contributor.authorCheng, IKPen_HK
dc.contributor.authorLai, KNen_HK
dc.date.accessioned2010-09-06T07:43:57Z-
dc.date.available2010-09-06T07:43:57Z-
dc.date.issued1999en_HK
dc.identifier.citationQjm - Monthly Journal Of The Association Of Physicians, 1999, v. 92 n. 7, p. 401-406en_HK
dc.identifier.issn0033-5622en_HK
dc.identifier.urihttp://hdl.handle.net/10722/78535-
dc.description.abstractWe retrospectively studied the clinical course and treatment outcome of idiopathic membranous nephropathy (IMN) amongst 38 Chinese patients (25 male, 13 female, age 51.6 ± 14.6 years, follow-up duration 58.2 ± 51.1 months) who presented over a 10-year review period. Eight never received any form of specific treatment (group I), seven received oral corticosteroid alone for 6-9 months (group II), 17 were given corticosteroid plus cyclophosphamide for 6-12 months (group III), and six were treated with methylprednisolone alternating with chlorambucil every other month for 6 months (group IV). No untoward effect from drugs sufficient to alter the dosage used was recorded. After 6 months of treatment, over 50% of patients went into remission: a significant reduction in proteinuria (p = 0.01, 0.01, 0.02) with a corresponding rise in serum albumin levels (p = 0.01, 0.01, 0.04) was observed in groups II, III, and IV, respectively, but not in group I. During follow-up, one patient in each of groups I, III, IV, and two of group II developed renal function deterioration, which correlated with an abnormal presenting serum creatinine. In six group I and eight group III patients who have been followed for at least 5 years, there was progressive reduction in proteinuria in group III (p < 0.05), but not in group I: serum creatinine has remained unchanged in both groups. IMN runs a benign course in Chinese patients in Hong Kong, with 2.6% of patients going into end-stage renal failure during the study period. Contrary to reports in Caucasians, there is similar treatment response to steroid alone or a combination of steroid and cytotoxic agents.en_HK
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://qjmed.oxfordjournals.org/en_HK
dc.relation.ispartofQJM - Monthly Journal of the Association of Physiciansen_HK
dc.rightsQ J M. Copyright © Oxford University Press.en_HK
dc.subject.meshAgeden_HK
dc.subject.meshAntihypertensive Agents - therapeutic useen_HK
dc.subject.meshChlorambucil - therapeutic useen_HK
dc.subject.meshCreatinine - blooden_HK
dc.subject.meshCyclophosphamide - therapeutic useen_HK
dc.subject.meshDrug Therapy, Combinationen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshGlomerulonephritis, Membranous - drug therapy - ethnology - metabolismen_HK
dc.subject.meshGlucocorticoids - therapeutic useen_HK
dc.subject.meshHong Kong - ethnologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshImmunosuppressive Agents - therapeutic useen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPrednisolone - therapeutic useen_HK
dc.subject.meshProteinuria - metabolismen_HK
dc.subject.meshRetrospective Studiesen_HK
dc.subject.meshSerum Albumin - analysisen_HK
dc.titleClinical features and treatment outcome of idiopathic membranous nephropathy in Chinese patientsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1460-2725&volume=92&spage=401&epage=406&date=1999&atitle=Clinical+features+and+treatment+outcome+of+idiopathic+membranous+nephropathy+in+Chinese+patientsen_HK
dc.identifier.emailTang, S: scwtang@hku.hken_HK
dc.identifier.emailChan, TM: dtmchan@hku.hken_HK
dc.identifier.emailLai, KN: knlai@hku.hken_HK
dc.identifier.authorityTang, S=rp00480en_HK
dc.identifier.authorityChan, TM=rp00394en_HK
dc.identifier.authorityLai, KN=rp00324en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.pmid10627890-
dc.identifier.scopuseid_2-s2.0-0032806194en_HK
dc.identifier.hkuros49781en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0032806194&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume92en_HK
dc.identifier.issue7en_HK
dc.identifier.spage401en_HK
dc.identifier.epage406en_HK
dc.identifier.isiWOS:000081627600007-
dc.identifier.scopusauthoridTang, S=7403437082en_HK
dc.identifier.scopusauthoridChan, TM=7402687700en_HK
dc.identifier.scopusauthoridCheng, IKP=7102537483en_HK
dc.identifier.scopusauthoridLai, KN=7402135706en_HK

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