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Professor Tang, Sydney Chi Wai 鄧智偉

Title:
Yu Professorship in Nephrology
Clinical Professor

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Tel:
2255 4777
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Professor Tang, Sydney Chi Wai 鄧智偉

Title:
Yu Professorship in Nephrology
Clinical Professor

Also Cited As:
Tang, S
Tang, Chi-wai, Sydney

Biography

Professor Sydney TANG is currently Clinical Professor of Medicine and Yu Professor in Nephrology at the University of Hong Kong. He underwent his training in Nephrology and Internal Medicine at the University of Hong Kong, King's College London, UK and the University of Washington, WA, USA.

Professor Tang is known for his contribution to both clinical and basic sciences in the field of nephrology. The research team has dissected some of the most important intracellular pathways through which excessive albumin, high glucose and glycated proteins induce toxicity to kidney tubule cells, the very cell type in the kidney that determines ultimate clinical outcomes in patients with chronic kidney disease. Albumin is a strong stimulus for tubular interleukin-8 overexpression through activation of nuclear factor-kappa B-dependent pathways, providing a mechanism for the occurrence of interstitial inflammatory cell infiltration that is observed in all forms of chronic proteinuric nephropathies. High glucose activates the Toll-like receptor that senses and reacts to diabetic injury in the kidney, and these observations are reproduced using gene knockout animal models, thus providing a novel therapeutic target for diabetic nephropathy which is currently the most prevalent disease leading to kidney failure in developed countries. In IgA nephropathy, a podocyte and glomerular-interstitial cross-talk pathway exists to mediate the occurrence of proteinuria and tubulointerstitial injury. The results of these observations have been published in J Clin Invest, J Am Soc Nephrol, and Kidney Int.

In the realm of clinical science, the focus is on the prevalence and mechanism of sleep apnea in patients with kidney disease and the treatment of IgA nephropathy, the commonest form of primary nephropathy worldwide. The prevalence of sleep apnea among peritoneal dialysis patients could be as high as 60-90%, and this is mainly related to fluid accumulation in the upper airway during sleep leading to obstructive sleep apnea, and accumulation of uremic toxins leading to central sleep apnea. In IgA nephropathy, both immunosuppressive and non-immunomodulating approaches may partially ameliorate proteinuria, a key prognostic biomarker in chronic nephropathies, in selected patient groups. The results of these observations have been published in Clin J Am Soc Nephrol, J Am Soc Nephrol, and Kidney Int.

 
Honours, Awards & Prizes
AwardeesAward DateHonours / Awards / PrizesCategory
Chu, LW
Chan, HWF
2014-07-01Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000): Seed Funding HKU
Research Achievement
2005-01-01Investigator Award. Prize: Research credit for a total of ten antibody products from Santa Cruz.: Santa Cruz Biotechnology Inc., Heidelberg, Germany
Research Achievement
2007-10-01Best Presenter Medal, Annual Scientific Meeting: Hong Kong College of Physicians
Research Achievement
2004-12-01Best Presentation Award, 9th Research Postgraduate Symposium for PhD Candidates. Prize: Airfare to USA: The University of Hong Kong
Research Achievement
2003-10-01Best Presenter Medal, Annual Scientific Meeting: Hong Kong College of Physicians
Research Achievement
2009-12-01Faculty Teaching Medal: LKS Faculty of Medicine, The University of Hong Kong
Teaching Accomplishment
2010-09-01Publication Award, for publication in Journal in the top 10% of the subspecialty, HK$ 10,000
Research Achievement
2010-12-01Award of one PDF post with 50% Central funding and 25% funding from the RCII
Research Achievement
1998-01-01Young Investigator Award for Best Oral Presentation, 3rd Medical Research Conference, Department of Medicine: The University of Hong Kong
Research Achievement
Ng, T
Liao, X
2012-05-01PI: (March 2012). Investigation of therapeutic efficacy and mechanisms of polysaccharide of Dendrobium officinale in alleviating cigarette-induced pulmonary inflammation.: Innovation and Technology Support Programme, the Government of the Hong Kong Special Administrative Region (Project code: InP/067/12).
Research Achievement
2002-01-01Young Investigator Award for Best Oral Presentation, 7th Medical Research Conference, Department of Medicine.: The University of Hong Kong
Research Achievement
2006-10-01Best Presenter Medal, Annual Scientific Meeting: Hong Kong College of Physicians
Research Achievement
Ng, TB
Liao, XQ
2012-04-01PI: (April 2012). Investigation of Therapeutic Efficacy and Mechanisms of Polysaccharide of Dendrobium officinale in Alleviating Cigarette-Induced Pulmonary Inflammation.: Innovation and Technology Fund Internship Programme of Hong Kong (Project code: InP/066/12).
Research Achievement
1997-01-01Croucher Foundation Fellowship Award: Croucher Foundation
Research Achievement
2013-06-01King's/HKU Fellowship Award, HK$ 50,000: The University of Hong Kong
Research Achievement
2010-08-01GRF Incentive Award 2010-11 (HKU 778910M), HK$ 25,000
Research Achievement
2010-08-01Staff Incentive Award, Department of Medicine for fundable-but-not-funded GRF application (score 3.5), HK$ 50,000
Research Achievement
2002-07-01Presentation of Excellence Award, 39th Congress of the European Renal Association, Copenhagen, Denmark: European Renal Association and European Dialysis and Transplant Association
Research Achievement
2007-10-01Ten Outstanding Young Persons Award: Junior Chamber International Hong Kong
Research Achievement
2006-10-01Distinguished Research Paper Award for Young Clinicians. Cash Prize: HK$ 5,000: Hong Kong College of Physicians
Research Achievement
2001-01-01Young Investigator Award for Best Oral Presentation, 6th Medical Research Conference, Department of Medicine: The University of Hong Kong
Research Achievement
2007-10-01Distinguished Research Paper Award for Young Clinicians. Cash Prize: HK$ 5,000: Hong Kong College of Physicians
Research Achievement
2012-04-01Yu Professorship in Nephrology: The University of Hong Kong
Research Achievement
Ng, TB
Liao, QX
2012-03-01PI: (May 2012). Investigation of therapeutic efficacy and mechanisms of polysaccharide of Dendrobium officinale in alleviating cigarette-induced pulmonary inflammation.: Innovation and Technology Support Programme, the Government of the Hong Kong Special Administrative Region. (Project code: ITS/313/11).
Research Achievement
2002-10-01Sir David Todd Lectureship Award: Hong Kong College of Physicians
Research Achievement
2005-10-01Best Poster Presentation Award, Annual Scientific Meeting: Hong Kong Society of Nephrology
Research Achievement
2001-03-01Visiting Young Investigator Award, 6th Asian Nephrology Forum. Cash prize: ¥ 200,000: Juntendo University School of Medicine, Tokyo, Japan
Research Achievement
2004-01-01Clinical Research Fellowship Scheme Award. Grant amount: HK$ 1,075,760: Research Grants Council, Hong Kong
Research Achievement
2001-10-01Best Oral Presentation in Basic Science Award, Annual Scientific Meeting: Hong Kong Society of Nephrology
Research Achievement
2002-10-01Distinguished Research Paper Award for Young Clinicians. Cash Prize HK$ 5,000: Hong Kong College of Physicians
Research Achievement
2004-05-01Young Investigator Award, 47th Annual Meeting of the Japanese Society of Nephrology, Utsunomiya, Japan. Cash Prize ¥ 120,000: Japanese Society of Nephrology
Research Achievement
2003-10-01Distinguished Research Paper Award for Young Clinicians. Cash Prize: HK$ 5,000: Hong Kong College of Physicians
Research Achievement
Professional Societies
Term PeriodPositionProfessional Societies
07/2006-06/2007Assitant Programe DirectorHong Kong College of Physicians
01/2002-01/2003MemberEuropean Renal Association
10/2014-Honorary SecretaryAsian Pacific Society of Nephrology
05/2008-Honorary TreasurerAsian Pacific Society of Nephrology
07/2015-ChairmanHong Kong College of Physicians Basic Physician Board
7/2011-Honorary SecretaryHong Kong College of Physicians Basic Physician Board
08/2004Scientific Committee Member, Conference on Prevention of Progression of Renal Disease 2004International Society of Nephrology
01/2003-MemberInternational Society of Nephrology
01/1995-MemberHong Kong Society of Transplantation
04/2012- 03/2015ChairmanHong Kong Medical Council Licentiate Committee Credentials Subcommittee
7/2011-Committee MemberHong Kong Medical Council Licentiate Committee
07/2003-Honorary Clinical SupervisorHong Kong College of Family Physicians
07/2007-Program Director in Basic Physician TrainingHong Kong College of Physicians
10/2004-10/2005Chief Examination Coordinator of Practical Assessment of Clinical Examination Skills (PACES) of the MRCP (UK) examination at Queen Mary HospitalHong Kong College of Physicians
07/2007-06/2009Board MemberHong Kong College of Physicians Basic Physicians Board
10/2012-Honorary TreasurerHong Kong Society of Nephrology
01/2005-Council MemberHong Kong Society of Nephrology
06/2005-06/2006Chairman, Organising Committee of the Hong Kong Renal Patients’ Gateball Competition 2005Hong Kong Society of Nephrology
12/1998Chairman, Organising Committee of the 5th Hong Kong Renal Patients’ Sports Day 1998Hong Kong Society of Nephrology
03/2008-08/2009Organizing Committee (Publication and Scientific Committee)Second Congress of International Society for Hemodialysis
7/2011-Board MemberHong Kong College of Physicians Nephrology Board
01/1999-Corresponding memberAmerican Society of Nephrology
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