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Article: 13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
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Title13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
 
AuthorsWong, WM1
Wong, BCY1
Wong, KW1
Fung, FMY1
Lai, KC1
Hu, WHC1
Yuen, ST1
Leung, SY1
Lau, GKK1
Lai, CL1
Chan, CK1
Go, R1
Lam, SK1
 
Issue Date2000
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
CitationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 10, p. 1353-1358 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
AbstractBackground: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
 
ISSN0269-2813
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
 
DOIhttp://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
ISI Accession Number IDWOS:000089910500016
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, WM
 
dc.contributor.authorWong, BCY
 
dc.contributor.authorWong, KW
 
dc.contributor.authorFung, FMY
 
dc.contributor.authorLai, KC
 
dc.contributor.authorHu, WHC
 
dc.contributor.authorYuen, ST
 
dc.contributor.authorLeung, SY
 
dc.contributor.authorLau, GKK
 
dc.contributor.authorLai, CL
 
dc.contributor.authorChan, CK
 
dc.contributor.authorGo, R
 
dc.contributor.authorLam, SK
 
dc.date.accessioned2010-09-06T07:38:21Z
 
dc.date.available2010-09-06T07:38:21Z
 
dc.date.issued2000
 
dc.description.abstractBackground: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 10, p. 1353-1358 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
dc.identifier.epage1358
 
dc.identifier.hkuros59761
 
dc.identifier.isiWOS:000089910500016
 
dc.identifier.issn0269-2813
2013 Impact Factor: 5.478
2013 SCImago Journal Rankings: 2.609
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmid11012482
 
dc.identifier.scopuseid_2-s2.0-0033623145
 
dc.identifier.spage1353
 
dc.identifier.urihttp://hdl.handle.net/10722/78026
 
dc.identifier.volume14
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
 
dc.title13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
 
dc.typeArticle
 
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<contributor.author>Lai, KC</contributor.author>
<contributor.author>Hu, WHC</contributor.author>
<contributor.author>Yuen, ST</contributor.author>
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<description.abstract>Background: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the &apos;gold standard&apos; (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong