Article: 13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese

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Title13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
AuthorsWong, WM1
Wong, BCY1
Wong, KW1
Fung, FMY1
Lai, KC1
Hu, WHC1
Yuen, ST1
Leung, SY1
Lau, GKK1
Lai, CL1
Chan, CK1
Go, R1
Lam, SK1
Issue Date2000
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
CitationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 10, p. 1353-1358 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
AbstractBackground: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
ISSN0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
DOIhttp://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
ISI Accession Number IDWOS:000089910500016
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorWong, WM
dc.contributor.authorWong, BCY
dc.contributor.authorWong, KW
dc.contributor.authorFung, FMY
dc.contributor.authorLai, KC
dc.contributor.authorHu, WHC
dc.contributor.authorYuen, ST
dc.contributor.authorLeung, SY
dc.contributor.authorLau, GKK
dc.contributor.authorLai, CL
dc.contributor.authorChan, CK
dc.contributor.authorGo, R
dc.contributor.authorLam, SK
dc.date.accessioned2010-09-06T07:38:21Z
dc.date.available2010-09-06T07:38:21Z
dc.date.issued2000
dc.description.abstractBackground: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 10, p. 1353-1358 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
dc.identifier.epage1358
dc.identifier.hkuros59761
dc.identifier.isiWOS:000089910500016
dc.identifier.issn0269-2813
2011 Impact Factor: 3.769
2011 SCImago Journal Rankings: 0.338
dc.identifier.issue10
dc.identifier.openurl
dc.identifier.scopuseid_2-s2.0-0033623145
dc.identifier.spage1353
dc.identifier.urihttp://hdl.handle.net/10722/78026
dc.identifier.volume14
dc.languageeng
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
dc.publisher.placeUnited Kingdom
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
dc.relation.referencesReferences in Scopus
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
dc.title13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong