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Article: 13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
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Title13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
 
AuthorsWong, WM1 1
Wong, BCY1 1
Wong, KW1 1
Fung, FMY1 1
Lai, KC1 1
Hu, WHC1 1
Yuen, ST1 1
Leung, SY1 1
Lau, GKK1 1
Lai, CL1 1
Chan, CK1 1
Go, R1 1
Lam, SK1 1
 
Issue Date2000
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
CitationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 10, p. 1353-1358 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
AbstractBackground: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
 
ISSN0269-2813
2012 Impact Factor: 4.548
2012 SCImago Journal Rankings: 1.689
 
DOIhttp://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
ISI Accession Number IDWOS:000089910500016
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorWong, WM
 
dc.contributor.authorWong, BCY
 
dc.contributor.authorWong, KW
 
dc.contributor.authorFung, FMY
 
dc.contributor.authorLai, KC
 
dc.contributor.authorHu, WHC
 
dc.contributor.authorYuen, ST
 
dc.contributor.authorLeung, SY
 
dc.contributor.authorLau, GKK
 
dc.contributor.authorLai, CL
 
dc.contributor.authorChan, CK
 
dc.contributor.authorGo, R
 
dc.contributor.authorLam, SK
 
dc.date.accessioned2010-09-06T07:38:21Z
 
dc.date.available2010-09-06T07:38:21Z
 
dc.date.issued2000
 
dc.description.abstractBackground: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the 'gold standard' (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationAlimentary Pharmacology And Therapeutics, 2000, v. 14 n. 10, p. 1353-1358 [How to Cite?]
DOI: http://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
dc.identifier.doihttp://dx.doi.org/10.1046/j.1365-2036.2000.00843.x
 
dc.identifier.epage1358
 
dc.identifier.hkuros59761
 
dc.identifier.isiWOS:000089910500016
 
dc.identifier.issn0269-2813
2012 Impact Factor: 4.548
2012 SCImago Journal Rankings: 1.689
 
dc.identifier.issue10
 
dc.identifier.openurl
 
dc.identifier.pmid11012482
 
dc.identifier.scopuseid_2-s2.0-0033623145
 
dc.identifier.spage1353
 
dc.identifier.urihttp://hdl.handle.net/10722/78026
 
dc.identifier.volume14
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/APT
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofAlimentary Pharmacology and Therapeutics
 
dc.relation.referencesReferences in Scopus
 
dc.rightsAlimentary Pharmacology and Therapeutics. Copyright © Blackwell Publishing Ltd.
 
dc.title13C-urea breath test without a test meal is highly accurate for the detection of Helicobacter pylori infection in Chinese
 
dc.typeArticle
 
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<contributor.author>Lai, KC</contributor.author>
<contributor.author>Hu, WHC</contributor.author>
<contributor.author>Yuen, ST</contributor.author>
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<description.abstract>Background: Conventional 13C-urea breath testing ( 13C-UBT) includes a test meal to delay gastric emptying, which, theoretically, improves the accuracy of the test. Citric acid has been proposed as the best test meal. However, recent studies have suggested that a test meal may not be necessary. Aim: To investigate a new 13C-UBT protocol without a test meal in a Chinese population. Methods: Consecutive dyspeptic patients referred for upper endoscopy were recruited. 13C-UBT was performed on two separate days with or without a test meal (2.4 Gm citric acid) and compared with the &apos;gold standard&apos; (CLO test and histology). Results: Two hundred and two patients were tested. Using receiver operating characteristics (ROC) analysis, the optimal delta-value and optimal measurement interval for UBT were 5% and 30 min, respectively, both with or without a test meal. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of 13C-UBT with citric acid (96.5%, 97.7%, 98.2%, 95.6%, 97.0%) were similar to 13C-UBT without a test meal (94.7%, 97.7%, 98.2%, 93.5%, 96.0%). Conclusion: This simplified 13C-UBT protocol without a test meal produced highly accurate and reliable results in the Chinese population.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong