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Article: Low molecular weight heparin-induced liver toxicity

TitleLow molecular weight heparin-induced liver toxicity
Authors
Issue Date2001
PublisherSage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=169
Citation
Journal Of Clinical Pharmacology, 2001, v. 41 n. 6, p. 691-694 How to Cite?
AbstractThe authors report two cases of hepatotoxicity induced by low molecular weight heparin. A 26-year-old woman and a 33-year-old man were treated with low molecular weight heparin for pulmonary embolism and cerebral infarction, respectively. They both developed derangement in liver function tests a few days after commencement of the low molecular weight heparin. The derangement in liver function tests was associated with a decreased serum complement 3 activity. Their liver functions recovered over a period of 2 to 3 months after low molecular weight heparin was stopped. Liver biopsy in the woman demonstrated balloon degeneration with scattered foci of hepatocytic necrosis, suggesting a complement-mediated hepatocellular damage. ©2001 the American College of Clinical Pharmacology.
Persistent Identifierhttp://hdl.handle.net/10722/77603
ISSN
2015 Impact Factor: 2.555
2015 SCImago Journal Rankings: 0.972
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, CKen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorTsang, KWTen_HK
dc.contributor.authorFong, GCYen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:33:41Z-
dc.date.available2010-09-06T07:33:41Z-
dc.date.issued2001en_HK
dc.identifier.citationJournal Of Clinical Pharmacology, 2001, v. 41 n. 6, p. 691-694en_HK
dc.identifier.issn0091-2700en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77603-
dc.description.abstractThe authors report two cases of hepatotoxicity induced by low molecular weight heparin. A 26-year-old woman and a 33-year-old man were treated with low molecular weight heparin for pulmonary embolism and cerebral infarction, respectively. They both developed derangement in liver function tests a few days after commencement of the low molecular weight heparin. The derangement in liver function tests was associated with a decreased serum complement 3 activity. Their liver functions recovered over a period of 2 to 3 months after low molecular weight heparin was stopped. Liver biopsy in the woman demonstrated balloon degeneration with scattered foci of hepatocytic necrosis, suggesting a complement-mediated hepatocellular damage. ©2001 the American College of Clinical Pharmacology.en_HK
dc.languageengen_HK
dc.publisherSage Science Press (US). The Journal's web site is located at http://www.sagepub.com/journal.aspx?pid=169en_HK
dc.relation.ispartofJournal of Clinical Pharmacologyen_HK
dc.subject.meshDrug-Induced Liver Injury-
dc.subject.meshEnoxaparin - adverse effects-
dc.subject.meshLiver - drug effects - pathology - physiopathology-
dc.subject.meshNadroparin - adverse effects-
dc.subject.meshPulmonary Embolism - drug therapy-
dc.titleLow molecular weight heparin-induced liver toxicityen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0091-2700&volume=41&issue=6&spage=691&epage=694&date=2001&atitle=Low+molecular+weight+heparin-induced+liver+toxicityen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1177/00912700122010465en_HK
dc.identifier.pmid11402639-
dc.identifier.scopuseid_2-s2.0-0035002101en_HK
dc.identifier.hkuros59753en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035002101&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue6en_HK
dc.identifier.spage691en_HK
dc.identifier.epage694en_HK
dc.identifier.isiWOS:000168948200013-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridHui, CK=7202876933en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK
dc.identifier.scopusauthoridFong, GCY=7004978754en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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