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Article: HBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects

TitleHBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects
Authors
Issue Date2004
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/
Citation
Hepatology, 2004, v. 39 n. 6, p. 1694-1701 How to Cite?
AbstractFew studies have examined Chinese patients with chronic hepatitis B who exhibit hepatitis B surface antigen (HBsAg) seroclearance. We comprehensively studied the biochemical, virological, histological, and clinical aspects of 92 patients with HBsAg seroclearance (median follow-up, 126 months). Ninety-two HBsAg-positive controls matched for age, sex, and duration of follow-up were also recruited. Liver biochemistry, serum hepatitis B virus (HBV) DNA levels, and development of clinical complications were monitored. Intrahepatic total and covalently closed circular (ccc) HBV DNA were measured quantitatively in 16 patients. HBV genotype was determined in 30 patients. The mean age at HBsAg seroclearance was 48.8 (+ 13.81) years. There was a significant improvement in serum alanine aminotransferase levels after HBsAg seroclearance (p<0.0001). Patients with genotype B had a higher chance of HBsAg seroclearance than those with genotype C (P = .014). Ninety-eight percent of patients had undetectable serum HBV DNA. Thirty-seven percent of patients had low titer of intrahepatic HBV DNA, mainly in the form of cccDNA (71%-100%). All 14 patients with liver biopsies had near normal histology. There was no difference in the risk of development of hepatocellular carcinoma (HCC) between patients with and without HBsAg seroclearance. However, the mean age of HBsAg seroclearance was significantly older in patients with HCC than in patients without HCC (P = .016). In conclusion, patients with HBsAg seroclearance had favorable biochemical, virological, and histological parameters. Intrahepatic HBV DNA level was low and predominantly in the form of cccDNA. However, HCC could still develop, particularly in patients with cirrhosis who had HBsAg seroclearance at an older age.
Persistent Identifierhttp://hdl.handle.net/10722/77554
ISSN
2015 Impact Factor: 11.711
2015 SCImago Journal Rankings: 4.752
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorWong, DKHen_HK
dc.contributor.authorSablon, Een_HK
dc.contributor.authorTse, Een_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorYuan, HJen_HK
dc.contributor.authorSiu, CWen_HK
dc.contributor.authorSander, TJen_HK
dc.contributor.authorBourne, EJen_HK
dc.contributor.authorHall, JGen_HK
dc.contributor.authorCondreay, LDen_HK
dc.contributor.authorLai, CLen_HK
dc.date.accessioned2010-09-06T07:33:10Z-
dc.date.available2010-09-06T07:33:10Z-
dc.date.issued2004en_HK
dc.identifier.citationHepatology, 2004, v. 39 n. 6, p. 1694-1701en_HK
dc.identifier.issn0270-9139en_HK
dc.identifier.urihttp://hdl.handle.net/10722/77554-
dc.description.abstractFew studies have examined Chinese patients with chronic hepatitis B who exhibit hepatitis B surface antigen (HBsAg) seroclearance. We comprehensively studied the biochemical, virological, histological, and clinical aspects of 92 patients with HBsAg seroclearance (median follow-up, 126 months). Ninety-two HBsAg-positive controls matched for age, sex, and duration of follow-up were also recruited. Liver biochemistry, serum hepatitis B virus (HBV) DNA levels, and development of clinical complications were monitored. Intrahepatic total and covalently closed circular (ccc) HBV DNA were measured quantitatively in 16 patients. HBV genotype was determined in 30 patients. The mean age at HBsAg seroclearance was 48.8 (+ 13.81) years. There was a significant improvement in serum alanine aminotransferase levels after HBsAg seroclearance (p<0.0001). Patients with genotype B had a higher chance of HBsAg seroclearance than those with genotype C (P = .014). Ninety-eight percent of patients had undetectable serum HBV DNA. Thirty-seven percent of patients had low titer of intrahepatic HBV DNA, mainly in the form of cccDNA (71%-100%). All 14 patients with liver biopsies had near normal histology. There was no difference in the risk of development of hepatocellular carcinoma (HCC) between patients with and without HBsAg seroclearance. However, the mean age of HBsAg seroclearance was significantly older in patients with HCC than in patients without HCC (P = .016). In conclusion, patients with HBsAg seroclearance had favorable biochemical, virological, and histological parameters. Intrahepatic HBV DNA level was low and predominantly in the form of cccDNA. However, HCC could still develop, particularly in patients with cirrhosis who had HBsAg seroclearance at an older age.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.hepatology.org/en_HK
dc.relation.ispartofHepatologyen_HK
dc.rightsHepatology. Copyright © John Wiley & Sons, Inc.en_HK
dc.subject.meshAdulten_HK
dc.subject.meshCarcinoma, Hepatocellular - etiologyen_HK
dc.subject.meshDNA, Viral - analysisen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshFollow-Up Studiesen_HK
dc.subject.meshHepatitis B Surface Antigens - blood - immunologyen_HK
dc.subject.meshHepatitis B virus - genetics - immunologyen_HK
dc.subject.meshHepatitis B, Chronic - blood - complications - immunology - pathology - virologyen_HK
dc.subject.meshHumansen_HK
dc.subject.meshLiver - chemistry - pathologyen_HK
dc.subject.meshLiver Cirrhosis - etiologyen_HK
dc.subject.meshLiver Neoplasms - etiologyen_HK
dc.subject.meshMaleen_HK
dc.titleHBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspectsen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0270-9139&volume=39&issue=6&spage=1694&epage=1701&date=2004&atitle=HBsAg+seroclearance+in+chronic+hepatitis+B+in+the+Chinese:+Virological,+histological,+and+clinical+aspectsen_HK
dc.identifier.emailYuen, MF:mfyuen@hkucc.hku.hken_HK
dc.identifier.emailWong, DKH:danywong@hku.hken_HK
dc.identifier.emailTse, E:ewctse@hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailSiu, CW:cwdsiu@hkucc.hku.hken_HK
dc.identifier.emailLai, CL:hrmelcl@hku.hken_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityWong, DKH=rp00492en_HK
dc.identifier.authorityTse, E=rp00471en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authoritySiu, CW=rp00534en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hep.20240en_HK
dc.identifier.pmid15185311-
dc.identifier.scopuseid_2-s2.0-2542516261en_HK
dc.identifier.hkuros90258en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2542516261&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume39en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1694en_HK
dc.identifier.epage1701en_HK
dc.identifier.isiWOS:000221849000027-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridWong, DKH=7401535819en_HK
dc.identifier.scopusauthoridSablon, E=6603694538en_HK
dc.identifier.scopusauthoridTse, E=7005019454en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridYuan, HJ=7402446707en_HK
dc.identifier.scopusauthoridSiu, CW=7006550690en_HK
dc.identifier.scopusauthoridSander, TJ=7006529559en_HK
dc.identifier.scopusauthoridBourne, EJ=6701720023en_HK
dc.identifier.scopusauthoridHall, JG=7407379623en_HK
dc.identifier.scopusauthoridCondreay, LD=7004527800en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK

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