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Article: Tuberculous infection in southern Chinese renal transplant recipients
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TitleTuberculous infection in southern Chinese renal transplant recipients
 
AuthorsLui, SL1
Tang, S1
Li, FK1
Choy, BY1
Chan, TM1
Lo, WK1
Lai, KN1
 
KeywordsChinese
Renal transplantation
Tuberculosis
 
Issue Date2004
 
PublisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
 
CitationClinical Transplantation, 2004, v. 18 n. 6, p. 666-671 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-0012.2004.00263.x
 
AbstractA retrospective study of the prevalence and pattern of tuberculosis among renal transplant patients in a single centre in southern China was performed. Twenty-three cases of tuberculosis were diagnosed among 440 patients between January 1991 and December 2002. There were 18 men and five women. The mean age of the patients was 39.3 ± 13.4 yr. There were 13 living-related and 10 cadaveric renal transplants. The interval between renal transplantation and the development of tuberculosis ranged from 3 to 127 months with a median of 46 months. There were 18 cases of pulmonary tuberculosis, two cases of pulmonary plus laryngeal tuberculosis, two cases of disseminated tuberculosis, and one case of tuberculosis involving the urinary tract. Diagnosis was established by positive culture for Mycobacterium tuberculosis in 21 patients and response to empirical anti-tuberculosis treatment in two patients. The duration of symptoms before the diagnosis of tuberculosis was 27 ± 12 d. The patients were treated with standard anti-tuberculosis drugs for 11 ± 3 months. The anti-tuberculosis treatment was in general well-tolerated. Five patients developed transient hepatitis, three patients developed thrombocytopenia and five patients developed gouty arthritis. One patient died 2 months after initiation of anti-tuberculosis therapy. All other patients completed anti-tuberculosis treatment. No recurrence of tuberculosis was observed after a median follow-up of 90 months. We concluded that (i) tuberculosis is prevalent among southern Chinese renal transplant recipients; (ii) high index of suspicion for tuberculosis among renal transplant recipients is warranted to ensure early diagnosis and prompt initiation of treatment; and (iii) treatment with standard anti-tuberculosis drugs for an extended period of time is well-tolerated and is associated with favourable outcome. © Blackwell Munksgaard, 2004.
 
ISSN0902-0063
2012 Impact Factor: 1.634
2012 SCImago Journal Rankings: 0.702
 
DOIhttp://dx.doi.org/10.1111/j.1399-0012.2004.00263.x
 
ISI Accession Number IDWOS:000224803900008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLui, SL
 
dc.contributor.authorTang, S
 
dc.contributor.authorLi, FK
 
dc.contributor.authorChoy, BY
 
dc.contributor.authorChan, TM
 
dc.contributor.authorLo, WK
 
dc.contributor.authorLai, KN
 
dc.date.accessioned2010-09-06T07:25:37Z
 
dc.date.available2010-09-06T07:25:37Z
 
dc.date.issued2004
 
dc.description.abstractA retrospective study of the prevalence and pattern of tuberculosis among renal transplant patients in a single centre in southern China was performed. Twenty-three cases of tuberculosis were diagnosed among 440 patients between January 1991 and December 2002. There were 18 men and five women. The mean age of the patients was 39.3 ± 13.4 yr. There were 13 living-related and 10 cadaveric renal transplants. The interval between renal transplantation and the development of tuberculosis ranged from 3 to 127 months with a median of 46 months. There were 18 cases of pulmonary tuberculosis, two cases of pulmonary plus laryngeal tuberculosis, two cases of disseminated tuberculosis, and one case of tuberculosis involving the urinary tract. Diagnosis was established by positive culture for Mycobacterium tuberculosis in 21 patients and response to empirical anti-tuberculosis treatment in two patients. The duration of symptoms before the diagnosis of tuberculosis was 27 ± 12 d. The patients were treated with standard anti-tuberculosis drugs for 11 ± 3 months. The anti-tuberculosis treatment was in general well-tolerated. Five patients developed transient hepatitis, three patients developed thrombocytopenia and five patients developed gouty arthritis. One patient died 2 months after initiation of anti-tuberculosis therapy. All other patients completed anti-tuberculosis treatment. No recurrence of tuberculosis was observed after a median follow-up of 90 months. We concluded that (i) tuberculosis is prevalent among southern Chinese renal transplant recipients; (ii) high index of suspicion for tuberculosis among renal transplant recipients is warranted to ensure early diagnosis and prompt initiation of treatment; and (iii) treatment with standard anti-tuberculosis drugs for an extended period of time is well-tolerated and is associated with favourable outcome. © Blackwell Munksgaard, 2004.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationClinical Transplantation, 2004, v. 18 n. 6, p. 666-671 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1399-0012.2004.00263.x
 
dc.identifier.citeulike57937
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1399-0012.2004.00263.x
 
dc.identifier.epage671
 
dc.identifier.hkuros99045
 
dc.identifier.isiWOS:000224803900008
 
dc.identifier.issn0902-0063
2012 Impact Factor: 1.634
2012 SCImago Journal Rankings: 0.702
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmid15516241
 
dc.identifier.scopuseid_2-s2.0-8644232737
 
dc.identifier.spage666
 
dc.identifier.urihttp://hdl.handle.net/10722/76852
 
dc.identifier.volume18
 
dc.languageeng
 
dc.publisherBlackwell Munksgaard. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CTR
 
dc.publisher.placeDenmark
 
dc.relation.ispartofClinical Transplantation
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdult
 
dc.subject.meshChina
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshKidney Transplantation - adverse effects
 
dc.subject.meshMale
 
dc.subject.meshRetrospective Studies
 
dc.subject.meshTuberculosis - diagnosis - drug therapy - epidemiology - etiology
 
dc.subjectChinese
 
dc.subjectRenal transplantation
 
dc.subjectTuberculosis
 
dc.titleTuberculous infection in southern Chinese renal transplant recipients
 
dc.typeArticle
 
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<contributor.author>Choy, BY</contributor.author>
<contributor.author>Chan, TM</contributor.author>
<contributor.author>Lo, WK</contributor.author>
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<description.abstract>A retrospective study of the prevalence and pattern of tuberculosis among renal transplant patients in a single centre in southern China was performed. Twenty-three cases of tuberculosis were diagnosed among 440 patients between January 1991 and December 2002. There were 18 men and five women. The mean age of the patients was 39.3 &#177; 13.4 yr. There were 13 living-related and 10 cadaveric renal transplants. The interval between renal transplantation and the development of tuberculosis ranged from 3 to 127 months with a median of 46 months. There were 18 cases of pulmonary tuberculosis, two cases of pulmonary plus laryngeal tuberculosis, two cases of disseminated tuberculosis, and one case of tuberculosis involving the urinary tract. Diagnosis was established by positive culture for Mycobacterium tuberculosis in 21 patients and response to empirical anti-tuberculosis treatment in two patients. The duration of symptoms before the diagnosis of tuberculosis was 27 &#177; 12 d. The patients were treated with standard anti-tuberculosis drugs for 11 &#177; 3 months. The anti-tuberculosis treatment was in general well-tolerated. Five patients developed transient hepatitis, three patients developed thrombocytopenia and five patients developed gouty arthritis. One patient died 2 months after initiation of anti-tuberculosis therapy. All other patients completed anti-tuberculosis treatment. No recurrence of tuberculosis was observed after a median follow-up of 90 months. We concluded that (i) tuberculosis is prevalent among southern Chinese renal transplant recipients; (ii) high index of suspicion for tuberculosis among renal transplant recipients is warranted to ensure early diagnosis and prompt initiation of treatment; and (iii) treatment with standard anti-tuberculosis drugs for an extended period of time is well-tolerated and is associated with favourable outcome. &#169; Blackwell Munksgaard, 2004.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong