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Article: Malignant placental site trophoblastic tumor: A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization

TitleMalignant placental site trophoblastic tumor: A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization
Authors
KeywordsChromosome in situ hybridization
Comparative genomic hybridization
Cytogenetic study
Placental site trophoblastic tumor
Issue Date2002
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 2002, v. 94 n. 8, p. 2288-2294 How to Cite?
AbstractBACKGROUND. Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasm composed predominantly of intermediate trophoblast. Most showed benign behavior whereas 10-15% of PSTTs were clinically malignant with later recurrence and metastasis. Currently, there are no reliable means to predict clinical outcome, and cytogenetic information is scanty. METHODS. The clinicopathologic features of two cases of malignant PSTT were analyzed. Cytogenetic analysis was performed by comparative genomic hybridization (CGH) and chromosome in situ hybridization (CISH) using frozen tissue and paraffin embedded sections, respectively. RESULTS. Both patients were 32 years old at time of diagnosis. One patient with PSTT presented with menorrhagia, and the other presented with symptoms of missed abortion. Elevated serum human chorionic gonadotropin (HCG) was detected in both patients. Histologic examination showed the typical features of PSTT with high mitotic count (> 5/10 high-power fields). Ovarian and lung metastasis occurred in both patients. Immunohistochemical staining revealed an equal distribution of HCG and human placental lactogen. Cytogenetic studies by CISH showed that karyotypes of these two malignant PSTTs were diploid. Analysis of the tumor tissue by CGH did not show any changes in DNA copy numbers. CONCLUSIONS. The authors' study indicated that the two metastasizing PSTTs had balanced diploid karyotype. The malignant behavior of PSTTs may be not related to the DNA copy number changes. Such cytogenetic study may be useful in distinguishing metastatic PSTT from choriocarcinoma. © 2002 American Cancer Society.
Persistent Identifierhttp://hdl.handle.net/10722/71889
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXue, WCen_HK
dc.contributor.authorGuan, XYen_HK
dc.contributor.authorNgan, HYSen_HK
dc.contributor.authorShen, DHen_HK
dc.contributor.authorKhoo, USen_HK
dc.contributor.authorCheung, ANYen_HK
dc.date.accessioned2010-09-06T06:36:09Z-
dc.date.available2010-09-06T06:36:09Z-
dc.date.issued2002en_HK
dc.identifier.citationCancer, 2002, v. 94 n. 8, p. 2288-2294en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/71889-
dc.description.abstractBACKGROUND. Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasm composed predominantly of intermediate trophoblast. Most showed benign behavior whereas 10-15% of PSTTs were clinically malignant with later recurrence and metastasis. Currently, there are no reliable means to predict clinical outcome, and cytogenetic information is scanty. METHODS. The clinicopathologic features of two cases of malignant PSTT were analyzed. Cytogenetic analysis was performed by comparative genomic hybridization (CGH) and chromosome in situ hybridization (CISH) using frozen tissue and paraffin embedded sections, respectively. RESULTS. Both patients were 32 years old at time of diagnosis. One patient with PSTT presented with menorrhagia, and the other presented with symptoms of missed abortion. Elevated serum human chorionic gonadotropin (HCG) was detected in both patients. Histologic examination showed the typical features of PSTT with high mitotic count (> 5/10 high-power fields). Ovarian and lung metastasis occurred in both patients. Immunohistochemical staining revealed an equal distribution of HCG and human placental lactogen. Cytogenetic studies by CISH showed that karyotypes of these two malignant PSTTs were diploid. Analysis of the tumor tissue by CGH did not show any changes in DNA copy numbers. CONCLUSIONS. The authors' study indicated that the two metastasizing PSTTs had balanced diploid karyotype. The malignant behavior of PSTTs may be not related to the DNA copy number changes. Such cytogenetic study may be useful in distinguishing metastatic PSTT from choriocarcinoma. © 2002 American Cancer Society.en_HK
dc.languageengen_HK
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.rightsCancer. Copyright © John Wiley & Sons, Inc.en_HK
dc.subjectChromosome in situ hybridizationen_HK
dc.subjectComparative genomic hybridizationen_HK
dc.subjectCytogenetic studyen_HK
dc.subjectPlacental site trophoblastic tumoren_HK
dc.subject.meshAdulten_HK
dc.subject.meshCytogeneticsen_HK
dc.subject.meshDNA, Neoplasm - metabolismen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHumansen_HK
dc.subject.meshIn Situ Hybridizationen_HK
dc.subject.meshKaryotypingen_HK
dc.subject.meshPregnancyen_HK
dc.subject.meshTrophoblastic Tumor, Placental Site - genetics - metabolism - pathologyen_HK
dc.subject.meshUterine Neoplasms - genetics - metabolism - pathologyen_HK
dc.titleMalignant placental site trophoblastic tumor: A cytogenetic study using comparative genomic hybridization and chromosome in situ hybridizationen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0008-543X&volume=94&issue=8&spage=2288&epage=2294&date=2002&atitle=Malignant+placental+site+trophoblastic+tumor:+A+cytogenetic+study+using+comparative+genomic+hybridization+and+chromosome+in+situ+hybridizationen_HK
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_HK
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_HK
dc.identifier.emailKhoo, US:uskhoo@hkucc.hku.hken_HK
dc.identifier.emailCheung, ANY:anycheun@hkucc.hku.hken_HK
dc.identifier.authorityGuan, XY=rp00454en_HK
dc.identifier.authorityNgan, HYS=rp00346en_HK
dc.identifier.authorityKhoo, US=rp00362en_HK
dc.identifier.authorityCheung, ANY=rp00542en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/cncr.10424en_HK
dc.identifier.pmid12001129-
dc.identifier.scopuseid_2-s2.0-0037089619en_HK
dc.identifier.hkuros66056en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037089619&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume94en_HK
dc.identifier.issue8en_HK
dc.identifier.spage2288en_HK
dc.identifier.epage2294en_HK
dc.identifier.isiWOS:000175062700023-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridXue, WC=7103165268en_HK
dc.identifier.scopusauthoridGuan, XY=7201463221en_HK
dc.identifier.scopusauthoridNgan, HYS=34571944100en_HK
dc.identifier.scopusauthoridShen, DH=7401738584en_HK
dc.identifier.scopusauthoridKhoo, US=7004195799en_HK
dc.identifier.scopusauthoridCheung, ANY=54927484100en_HK

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