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Conference Paper: Contrast-enhanced MRI of hepatocellular carcinoma (HCC) in the presence of cirrhosis

TitleContrast-enhanced MRI of hepatocellular carcinoma (HCC) in the presence of cirrhosis
Authors
Issue Date2008
Citation
The 2008 World Molecular Imaging Congress, Nice, France, 10-13 September 2008. How to Cite?
AbstractAn early detection of HCC is crucial to increase the curability of the disease, and hence new hepatocyte-targeted magnetic resonance (MR) contrast agents have been developed to improve the delineation of the hepatocellular carcinoma (HCC). Gadolinium complexes with enhanced liver targeting are prepared and evaluated both in vitro and in vivo. The relaxivity of the new Gd complexes is 5-6 mM(-1)s(-1) and the intracellular concentrations of these Gd complexes in liver cells are significantly higher than that of the clinical contrast agent (Gadoterate meglumine). As compared with Gadoterate meglumine, one of the Gd complexes GdL has a high intracellular concentration, which results in a 23.5% and 39.2% increase in the R1 and R2 respectively in MIHA cells (Figure 1). The percentage increase in relaxivity is higher than that of the HepG2 cells, indicating the GdL gives a stronger signal in hepatocytes.
DescriptionPoster Session 3 - Presentation Number: 1504
Persistent Identifierhttp://hdl.handle.net/10722/62133

 

DC FieldValueLanguage
dc.contributor.authorChan, KWYen_HK
dc.contributor.authorLin, MMCen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorMan, Ken_HK
dc.contributor.authorLei, Hen_HK
dc.contributor.authorWong, WTen_HK
dc.date.accessioned2010-07-13T03:54:33Z-
dc.date.available2010-07-13T03:54:33Z-
dc.date.issued2008en_HK
dc.identifier.citationThe 2008 World Molecular Imaging Congress, Nice, France, 10-13 September 2008.en_HK
dc.identifier.urihttp://hdl.handle.net/10722/62133-
dc.descriptionPoster Session 3 - Presentation Number: 1504en_HK
dc.description.abstractAn early detection of HCC is crucial to increase the curability of the disease, and hence new hepatocyte-targeted magnetic resonance (MR) contrast agents have been developed to improve the delineation of the hepatocellular carcinoma (HCC). Gadolinium complexes with enhanced liver targeting are prepared and evaluated both in vitro and in vivo. The relaxivity of the new Gd complexes is 5-6 mM(-1)s(-1) and the intracellular concentrations of these Gd complexes in liver cells are significantly higher than that of the clinical contrast agent (Gadoterate meglumine). As compared with Gadoterate meglumine, one of the Gd complexes GdL has a high intracellular concentration, which results in a 23.5% and 39.2% increase in the R1 and R2 respectively in MIHA cells (Figure 1). The percentage increase in relaxivity is higher than that of the HepG2 cells, indicating the GdL gives a stronger signal in hepatocytes.-
dc.languageengen_HK
dc.relation.ispartofWorld Molecular Imaging Congress-
dc.titleContrast-enhanced MRI of hepatocellular carcinoma (HCC) in the presence of cirrhosisen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KWY: kwychan@hkucc.hku.hk, kannie@graduate.hku.hken_HK
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.emailMan, K: kwanman@hkucc.hku.hk-
dc.identifier.emailWong, WT: wtwong@hku.hk-
dc.identifier.hkuros161966en_HK
dc.description.otherThe 2008 World Molecular Imaging Congress, Nice, France, 10-13 September 2008.-

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