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Conference Paper: NMO-IgG in idiopathic inflammatory demyelinatingdisorders among Hong Kong Chinese

TitleNMO-IgG in idiopathic inflammatory demyelinatingdisorders among Hong Kong Chinese
Authors
Issue Date2008
PublisherWiley-Blackwell Publishing Ltd.
Citation
12th EFNS Congress, Madrid, Spain, 23-26 August 2008. In European Journal of Neurology, 2008, v. 15 n. s3, p. 141 Abstract no. 1425 How to Cite?
AbstractBackground and aims: Neuromyelitis optica (NMO) is character-ized by acute transverse myelitis (ATM) and optic neuritis (ON).NMO-IgG facilitates diagnosis of NMO, distinguished from clas-sical multiple sclerosis (CMS). We studied NMO-IgG seropositiv-ity rate among local patients with idiopathic inflammatorydemyelinating disorders.Methods: 94 patients (30 CMS, 30 ATM without ON, 19 ON with-out ATM, 10 ATM with ON not fulfilling diagnostic criteria ofCMS (revised McDonald criteria), 5 ADEM) were studied. Patientsand controls (10 healthy subjects, 27 other neurological disorders)sera were tested for NMO-IgG by indirect immunofluorescenceusing monkey cerebellum slides.Results: 6 of 10 (60%) patients with ATM and ON not fulfillingdiagnostic criteria for CMS were NMO-IgG positive. All 6 hadextensive ATM (>3 vertebral segments), 5 of 6 had severe visualimpairment. 2 of 6 had brainstem dysfunction clinically with MRIbrainstem abnormalities; MRI brain was otherwise normal for all6 who were CSF oligoclonal bands negative. 2 of 4 NMO-IgG neg-ative patients had extensive ATM and one severe visual impair-ment. Among 10 recurrent ATM without ON patients, 6 (60%)were NMO-IgG positive; all 6 had extensive ATM. None of 20 sin-gle ATM attack patients was NMO-IgG positive. 2 of 8 recurrentON without ATM patients were NMO-IgG positive; one of 11 sin-gle ON attack patients was NMO-IgG positive, she had bilateralON. One of 30 CMS patients was NMO-IgG positive. No controlwas NMO-IgG positive.Conclusion: 60% of local patients with NMO or recurrent exten-sive ATM without ON were NMO-IgG seropositive.
Persistent Identifierhttp://hdl.handle.net/10722/61909
ISSN
2015 Impact Factor: 3.956
2015 SCImago Journal Rankings: 1.669

 

DC FieldValueLanguage
dc.contributor.authorChan, KHen_HK
dc.contributor.authorRamsden, DBen_HK
dc.contributor.authorMak, HKFen_HK
dc.contributor.authorKwok, HHen_HK
dc.contributor.authorChu, ACYen_HK
dc.contributor.authorHo, SLen_HK
dc.date.accessioned2010-07-13T03:49:54Z-
dc.date.available2010-07-13T03:49:54Z-
dc.date.issued2008en_HK
dc.identifier.citation12th EFNS Congress, Madrid, Spain, 23-26 August 2008. In European Journal of Neurology, 2008, v. 15 n. s3, p. 141 Abstract no. 1425-
dc.identifier.issn1351-5101-
dc.identifier.urihttp://hdl.handle.net/10722/61909-
dc.description.abstractBackground and aims: Neuromyelitis optica (NMO) is character-ized by acute transverse myelitis (ATM) and optic neuritis (ON).NMO-IgG facilitates diagnosis of NMO, distinguished from clas-sical multiple sclerosis (CMS). We studied NMO-IgG seropositiv-ity rate among local patients with idiopathic inflammatorydemyelinating disorders.Methods: 94 patients (30 CMS, 30 ATM without ON, 19 ON with-out ATM, 10 ATM with ON not fulfilling diagnostic criteria ofCMS (revised McDonald criteria), 5 ADEM) were studied. Patientsand controls (10 healthy subjects, 27 other neurological disorders)sera were tested for NMO-IgG by indirect immunofluorescenceusing monkey cerebellum slides.Results: 6 of 10 (60%) patients with ATM and ON not fulfillingdiagnostic criteria for CMS were NMO-IgG positive. All 6 hadextensive ATM (>3 vertebral segments), 5 of 6 had severe visualimpairment. 2 of 6 had brainstem dysfunction clinically with MRIbrainstem abnormalities; MRI brain was otherwise normal for all6 who were CSF oligoclonal bands negative. 2 of 4 NMO-IgG neg-ative patients had extensive ATM and one severe visual impair-ment. Among 10 recurrent ATM without ON patients, 6 (60%)were NMO-IgG positive; all 6 had extensive ATM. None of 20 sin-gle ATM attack patients was NMO-IgG positive. 2 of 8 recurrentON without ATM patients were NMO-IgG positive; one of 11 sin-gle ON attack patients was NMO-IgG positive, she had bilateralON. One of 30 CMS patients was NMO-IgG positive. No controlwas NMO-IgG positive.Conclusion: 60% of local patients with NMO or recurrent exten-sive ATM without ON were NMO-IgG seropositive.-
dc.languageengen_HK
dc.publisherWiley-Blackwell Publishing Ltd.-
dc.relation.ispartofEuropean Journal of Neurology-
dc.titleNMO-IgG in idiopathic inflammatory demyelinatingdisorders among Hong Kong Chineseen_HK
dc.typeConference_Paperen_HK
dc.identifier.emailChan, KH: koonho@hkucc.hku.hken_HK
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_HK
dc.identifier.emailChu, ACY: bcccy@hkucc.hku.hken_HK
dc.identifier.emailHo, SL: slho@hku.hken_HK
dc.identifier.authorityChan, KH=rp00537en_HK
dc.identifier.authorityMak, HKF=rp00533en_HK
dc.identifier.authorityChu, ACY=rp00505en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1468-1331.2008.02285.x-
dc.identifier.hkuros142426en_HK

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