Dr Mak, Henry Ka Fung 麥嘉豐
I am a diagnostic neuroradiologist in the University of Hong Kong and was Clinical Instructor/Diagnostic Neuroradiology Fellow in the Division of Neuroradiology of Department of Radiology, University of Virginia Medical Center (USA) from March 2011 to February 2012.
My research focus is on neuroimaging of Alzheimer's disease in the local population. The functional neuroimaging tools such as functional Magnetic Resonance Imaging (fMRI), MR perfusion, Susceptibility-Weighted Imaging and MR Spectroscopy have developed rapidly in recent years, and I foresee their key diagnostic roles and applications in Alzheimer's and other neurodegenerative diseases, stroke, multiple sclerosis and neuromyelitis optica, and brain tumors.
Quantitative assessment of cerebral hemodynamic parameters by QUASAR Arterial Spin-Labeling in AD and cognitively normal elderly adults at 3-Tesla (JAD 2011). ASL- MRI is a non-invasive cerebral perfusion technique and is promising in assessing patients with cognitive imapirment. Absolute cerebral blood flow parameters correlated with clinical observed severity measurements in our study. Our findings also supported the alternative vascular hypothesis.
Efficacy of voxel-based morphometry with DARTEL and standard registration as imaging biomarkers in AD and cognitively normal elderly adults at 3-Tesla MR Imaging (JAD 2012). Quantitative MRI hippocampal volumetry achieved high efficacy for differentiation of the 2 groups, both by manual and semi-automated methods. The study demonstrated the robustness of hippocampal volumetry and its potential clinical application.
Pilot study on correlation of MR perfusion (Ktrans) and diffusion (ADC) parameters in brain tumors at 3-Tesla (Cancer Imaging 2012). Our findings suggested an intricate relationship between vascular permeability and tumor microenvironment based on a cohort of various tumor types. This was an exploratory study and provided insights into the tumor pathophysiology.
Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: Proton Magnetic Resonance Spectroscopy study at 3-tesla (AGE 2014). Our study found that the brain metabolite concentrations increase significantly with age in the anterior and posterior cingulate gyri, reflecting glial proliferaton and possible neuronal hypertrophy. We postulated that increased oxygen consumption despite a lower resting state blood flow with age (evidenced by BOLD-fMRI studies) could be explained by such metabolic findings.
|Awardees||Award Date||Honours / Awards / Prizes||Category|
|2003-01-01||Three-month overseas Research Fellowship: Ho Hung Chiu Foundation||Research Achievement|
|2011-03-01||Li Shu Pui Medical Foundation Clinical Fellowship 2011-12: Li Shu Pui Medical Foundation||Others|
|2013-05-01||Junior Investigator's Award for poster: Twenty Second European Stroke Conference, 28 to 31 May 2013, London, United Kingdom||Research Achievement|
|2014-07-01||Comparing vascular dementia and Alzheimer’s dementia: a preliminary, cross-sectional, multimodal comparative study evaluating clinical and cognitive profile, neuroimaging, biomarkers and quantitative EEG ($240,000): Seed Funding HKU||Research Achievement|
|2016-05-01||Selected Proffered Paper: Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices: The 24th Annual Meeting of ISMRM: Psychiatric MR Spectroscopy & Imaging Study Group||Research Achievement|
|Term Period||Position||Professional Societies|
|10/2004- present||Fellow||Hong Kong Stroke Society|
|07/2010-present||Member||International Society to Advance Alzheimer’s Research and Treatment|
|08/2008- present||Member||Asian Oceanic Society of Neuroradiology and Head and Neck Radiology|
|01/2003- present||Member||Radiological Society of North America|
|01/2000- present||Member||Hong Kong Society of Magnetic Resonance Imaging Technology|
|03/2012- present||Council Member||Hong Kong Neuro-Oncology Society|
|01/2002- present||Member||International Society for Magnetic Resonance Imaging in Medicine|
|01/2015-present||Scientific Subcommittee Member||Hong Kong College of Radiologists|
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