File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Adipocyte–fatty acid binding protein as a biomarker for 35 coronary atherosclerosis

TitleAdipocyte–fatty acid binding protein as a biomarker for 35 coronary atherosclerosis
Authors
Issue Date2009
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 14th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 10 January 2009. In Hong Kong Medical Journal, 2009, v. 15 n. 1, p. 35 How to Cite?
AbstractIntroduction: Obesity is associated with increased cardiovascular risk. Recent studies suggested that adipocyte– fatty acid binding protein (A-FABP) may have a role in mediating obesity-related metabolic and cardiovascular complications. Here, we investigated the association of baseline serum A-FABP with the severity of coronary atherosclerosis at 10 years in a Chinese cohort. Methods: A total of 408 asymptomatic subjects without a history of coronary heart disease (CHD) at baseline underwent computed tomography for coronary artery calcium score assessment (CACS) at 10-year follow-up. Results: Baseline A-FABP was significantly associated with the 10-year CACS (P<0.00001). A-FABP levels correlated with the Framingham risk score (FRS) at baseline (r=0.48, P<0.001). Significant additive effect of A-FABP to FRS in the prediction of coronary atherosclerosis at 10 years was observed, as demonstrated by significant likelihood ratios (P<0.001) and receiver operating characteristics curve analyses. On stepwise multinominal logistic regression analysis, serum A-FABP was a significant independent baseline predictor of CACS at 10 years (OR=2.04, 95% CI=1.22-3.43 for CACS 1-100 vs CACS=0, P=0.007; and OR=2.40, 95% CI=1.19-4.83 for CACS >100 vs CACS=0, P=0.014), together with age and male sex. Conclusion: A-FABP may serve as a useful marker, in combination with current risk assessment tools, to identify individuals at increased risk of CHD. Acknowledgement: This study was supported by the Hong Kong Research Grant Council (HKU7590/06M); Central Allocation (HKU 2/07C), and Hong Kong Innovation and Technology Fund (GHP/027/05).
Persistent Identifierhttp://hdl.handle.net/10722/61908
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorTso, AWK-
dc.contributor.authorOng, LHY-
dc.contributor.authorXu, A-
dc.contributor.authorMak, HKF-
dc.contributor.authorFong, CHY-
dc.contributor.authorWat, NMS-
dc.contributor.authorKhong, PL-
dc.contributor.authorLam, KSL-
dc.date.accessioned2010-07-13T03:49:53Z-
dc.date.available2010-07-13T03:49:53Z-
dc.date.issued2009-
dc.identifier.citationThe 14th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 10 January 2009. In Hong Kong Medical Journal, 2009, v. 15 n. 1, p. 35-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/61908-
dc.description.abstractIntroduction: Obesity is associated with increased cardiovascular risk. Recent studies suggested that adipocyte– fatty acid binding protein (A-FABP) may have a role in mediating obesity-related metabolic and cardiovascular complications. Here, we investigated the association of baseline serum A-FABP with the severity of coronary atherosclerosis at 10 years in a Chinese cohort. Methods: A total of 408 asymptomatic subjects without a history of coronary heart disease (CHD) at baseline underwent computed tomography for coronary artery calcium score assessment (CACS) at 10-year follow-up. Results: Baseline A-FABP was significantly associated with the 10-year CACS (P<0.00001). A-FABP levels correlated with the Framingham risk score (FRS) at baseline (r=0.48, P<0.001). Significant additive effect of A-FABP to FRS in the prediction of coronary atherosclerosis at 10 years was observed, as demonstrated by significant likelihood ratios (P<0.001) and receiver operating characteristics curve analyses. On stepwise multinominal logistic regression analysis, serum A-FABP was a significant independent baseline predictor of CACS at 10 years (OR=2.04, 95% CI=1.22-3.43 for CACS 1-100 vs CACS=0, P=0.007; and OR=2.40, 95% CI=1.19-4.83 for CACS >100 vs CACS=0, P=0.014), together with age and male sex. Conclusion: A-FABP may serve as a useful marker, in combination with current risk assessment tools, to identify individuals at increased risk of CHD. Acknowledgement: This study was supported by the Hong Kong Research Grant Council (HKU7590/06M); Central Allocation (HKU 2/07C), and Hong Kong Innovation and Technology Fund (GHP/027/05).-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleAdipocyte–fatty acid binding protein as a biomarker for 35 coronary atherosclerosis-
dc.typeConference_Paper-
dc.identifier.emailTso, AWK: awktso@HKUCC-COM.hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hk-
dc.identifier.emailKhong, PL: plkhong@hkucc.hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.authorityTso, AWK=rp00535-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityMak, HKF=rp00533-
dc.identifier.authorityKhong, PL=rp00467-
dc.identifier.authorityLam, KSL=rp00343-
dc.description.natureabstract-
dc.identifier.hkuros160914-
dc.identifier.volume15-
dc.identifier.issue1-
dc.identifier.spage35-
dc.identifier.epage35-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats