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Article: Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer

TitleSomatic mutations of the histone H3K27 demethylase gene UTX in human cancer
Authors
Van Haaften, GDalgliesh, GLDavies, HChen, LBignell, GGreenman, CEdkins, SHardy, CO'Meara, STeague, JButler, AHinton, JLatimer, CAndrews, JBarthorpe, SBeare, DBuck, GCampbell, PJCole, JForbes, SJia, MJones, DKok, CYLeroy, CLin, MLMcBride, DJMaddison, MMaquire, SMcLay, KMenzies, AMironenko, TMulderrig, LMudie, LPleasance, EShepherd, RSmith, RStebbings, LStephens, PTang, GTarpey, PSTurner, RTurrell, KVarian, JWest, SWidaa, SWray, PCollins, VPIchimura, KLaw, SWong, JYuen, STLeung, SYTonon, GDepinho, RATai, YTAnderson, KCKahnoski, RJMassie, AKhoo, SKTeh, BTStratton, MRFutreal, PA
Issue Date2009
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2009, v. 41 n. 5, p. 521-523 How to Cite?
DOI: http://dx.doi.org/10.1038/ng.349
AbstractSomatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene. © 2009 Nature America, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/60568
ISSN
1061-4036
2023 Impact Factor: 31.7
2023 SCImago Journal Rankings: 17.300
ISI Accession Number ID
WOS:000265575600011
Funding AgencyGrant Number
Wellcome Trus
EMBO fellowship
Kay Kendall Leukaemia Fund fellowship
Robert A. and Renee E. Belfer Foundation for Innovative Cancer Science
Leukemia and Lymphoma Society
Funding Information:

Funding was provided by the Wellcome Trust. G. v. H. is supported by an EMBO fellowship and P.J.C. by a Kay Kendall Leukaemia Fund fellowship. R. A. D. is supported by the Robert A. and Renee E. Belfer Foundation for Innovative Cancer Science. G. T. is supported by a fellowship from the Leukemia and Lymphoma Society. GlaxoSmithKline provided support for the SNP 6.0 microarray analyses. UTX antibodies were a kind gift from E. Canaani (Weizmann Institute of Science).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorVan Haaften, Gen_HK
dc.contributor.authorDalgliesh, GLen_HK
dc.contributor.authorDavies, Hen_HK
dc.contributor.authorChen, Len_HK
dc.contributor.authorBignell, Gen_HK
dc.contributor.authorGreenman, Cen_HK
dc.contributor.authorEdkins, Sen_HK
dc.contributor.authorHardy, Cen_HK
dc.contributor.authorO'Meara, Sen_HK
dc.contributor.authorTeague, Jen_HK
dc.contributor.authorButler, Aen_HK
dc.contributor.authorHinton, Jen_HK
dc.contributor.authorLatimer, Cen_HK
dc.contributor.authorAndrews, Jen_HK
dc.contributor.authorBarthorpe, Sen_HK
dc.contributor.authorBeare, Den_HK
dc.contributor.authorBuck, Gen_HK
dc.contributor.authorCampbell, PJen_HK
dc.contributor.authorCole, Jen_HK
dc.contributor.authorForbes, Sen_HK
dc.contributor.authorJia, Men_HK
dc.contributor.authorJones, Den_HK
dc.contributor.authorKok, CYen_HK
dc.contributor.authorLeroy, Cen_HK
dc.contributor.authorLin, MLen_HK
dc.contributor.authorMcBride, DJen_HK
dc.contributor.authorMaddison, Men_HK
dc.contributor.authorMaquire, Sen_HK
dc.contributor.authorMcLay, Ken_HK
dc.contributor.authorMenzies, Aen_HK
dc.contributor.authorMironenko, Ten_HK
dc.contributor.authorMulderrig, Len_HK
dc.contributor.authorMudie, Len_HK
dc.contributor.authorPleasance, Een_HK
dc.contributor.authorShepherd, Ren_HK
dc.contributor.authorSmith, Ren_HK
dc.contributor.authorStebbings, Len_HK
dc.contributor.authorStephens, Pen_HK
dc.contributor.authorTang, Gen_HK
dc.contributor.authorTarpey, PSen_HK
dc.contributor.authorTurner, Ren_HK
dc.contributor.authorTurrell, Ken_HK
dc.contributor.authorVarian, Jen_HK
dc.contributor.authorWest, Sen_HK
dc.contributor.authorWidaa, Sen_HK
dc.contributor.authorWray, Pen_HK
dc.contributor.authorCollins, VPen_HK
dc.contributor.authorIchimura, Ken_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorTonon, Gen_HK
dc.contributor.authorDepinho, RAen_HK
dc.contributor.authorTai, YTen_HK
dc.contributor.authorAnderson, KCen_HK
dc.contributor.authorKahnoski, RJen_HK
dc.contributor.authorMassie, Aen_HK
dc.contributor.authorKhoo, SKen_HK
dc.contributor.authorTeh, BTen_HK
dc.contributor.authorStratton, MRen_HK
dc.contributor.authorFutreal, PAen_HK
dc.date.accessioned2010-05-31T04:13:51Z-
dc.date.available2010-05-31T04:13:51Z-
dc.date.issued2009en_HK
dc.identifier.citationNature Genetics, 2009, v. 41 n. 5, p. 521-523en_HK
dc.identifier.issn1061-4036en_HK
dc.identifier.urihttp://hdl.handle.net/10722/60568-
dc.description.abstractSomatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene. © 2009 Nature America, Inc. All rights reserved.en_HK
dc.languageengen_HK
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_HK
dc.relation.ispartofNature Geneticsen_HK
dc.subject.meshEpigenesis, Geneticen_HK
dc.subject.meshHumansen_HK
dc.subject.meshJumonji Domain-Containing Histone Demethylasesen_HK
dc.subject.meshMutationen_HK
dc.subject.meshNeoplasms - enzymology - geneticsen_HK
dc.subject.meshOxidoreductases, N-Demethylating - geneticsen_HK
dc.titleSomatic mutations of the histone H3K27 demethylase gene UTX in human canceren_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1061-4036&volume=41&issue=5&spage=521&epage=523&date=2009&atitle=Somatic+mutations+of+the+histone+H3K27+demethylase+gene+UTX+in+human+canceren_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/ng.349en_HK
dc.identifier.pmid19330029-
dc.identifier.scopuseid_2-s2.0-67349203626en_HK
dc.identifier.hkuros155594en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349203626&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume41en_HK
dc.identifier.issue5en_HK
dc.identifier.spage521en_HK
dc.identifier.epage523en_HK
dc.identifier.isiWOS:000265575600011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.f10001158757-
dc.identifier.scopusauthoridVan Haaften, G=6506033769en_HK
dc.identifier.scopusauthoridDalgliesh, GL=7801426205en_HK
dc.identifier.scopusauthoridDavies, H=8910972700en_HK
dc.identifier.scopusauthoridChen, L=35315593300en_HK
dc.identifier.scopusauthoridBignell, G=6701507910en_HK
dc.identifier.scopusauthoridGreenman, C=8625570000en_HK
dc.identifier.scopusauthoridEdkins, S=6601990753en_HK
dc.identifier.scopusauthoridHardy, C=24331207400en_HK
dc.identifier.scopusauthoridO'Meara, S=6603894982en_HK
dc.identifier.scopusauthoridTeague, J=7004437563en_HK
dc.identifier.scopusauthoridButler, A=7201779747en_HK
dc.identifier.scopusauthoridHinton, J=15122142800en_HK
dc.identifier.scopusauthoridLatimer, C=26423060100en_HK
dc.identifier.scopusauthoridAndrews, J=35393498300en_HK
dc.identifier.scopusauthoridBarthorpe, S=15130751000en_HK
dc.identifier.scopusauthoridBeare, D=35236143300en_HK
dc.identifier.scopusauthoridBuck, G=15130514700en_HK
dc.identifier.scopusauthoridCampbell, PJ=35397659000en_HK
dc.identifier.scopusauthoridCole, J=8932052400en_HK
dc.identifier.scopusauthoridForbes, S=7102524551en_HK
dc.identifier.scopusauthoridJia, M=23766297200en_HK
dc.identifier.scopusauthoridJones, D=36072111200en_HK
dc.identifier.scopusauthoridKok, CY=23477430000en_HK
dc.identifier.scopusauthoridLeroy, C=35248766100en_HK
dc.identifier.scopusauthoridLin, ML=8269439800en_HK
dc.identifier.scopusauthoridMcBride, DJ=26423220300en_HK
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dc.identifier.scopusauthoridMaquire, S=26423178800en_HK
dc.identifier.scopusauthoridMcLay, K=6603360473en_HK
dc.identifier.scopusauthoridMenzies, A=15122609500en_HK
dc.identifier.scopusauthoridMironenko, T=36748247900en_HK
dc.identifier.scopusauthoridMulderrig, L=26423121700en_HK
dc.identifier.scopusauthoridMudie, L=26423199600en_HK
dc.identifier.scopusauthoridPleasance, E=7801404201en_HK
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dc.identifier.scopusauthoridTurner, R=55472723200en_HK
dc.identifier.scopusauthoridTurrell, K=26423391900en_HK
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dc.identifier.scopusauthoridWest, S=8910970300en_HK
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dc.identifier.scopusauthoridWray, P=8305243500en_HK
dc.identifier.scopusauthoridCollins, VP=7101885911en_HK
dc.identifier.scopusauthoridIchimura, K=7201778574en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
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dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridTonon, G=36871233300en_HK
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dc.identifier.scopusauthoridKahnoski, RJ=6602856710en_HK
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dc.identifier.scopusauthoridFutreal, PA=35377883800en_HK
dc.identifier.citeulike4311426-
dc.identifier.issnl1061-4036-

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