Article: Epidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis

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TitleEpidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
AuthorsYeung, DCY1 2
Wang, Y1
Xu, A1 2
Cheung, SCW3
Wat, NMS2
Fong, DYT1
Fong, CHY2
Chau, MT3
Sham, PC1
Lam, KSL1 2
KeywordsAtherosclerosis
Fatty-acid-binding proteins
Metabolic syndrome
Obesity
Risk factors
Issue Date2008
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
CitationEuropean Heart Journal, 2008, v. 29 n. 17, p. 2156-2163 [How to Cite?]
DOI: http://dx.doi.org/10.1093/eurheartj/ehn295
AbstractAims: Epidermal fatty-acid-binding protein (E-FABP) is highly homologous to adipocyte FABP (A-FABP), which mediates obesity-related metabolic syndrome (MetS), diabetes and atherosclerosis in animals. Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans. Methods and results: The presence of E-FABP in human plasma was detected by tandem mass spectrometry. Serum E-FABP levels, determined by an enzyme-linked immunosorbent assay in 479 Chinese subjects (age: 55.4 ± 13.5 years; M/F: 232/247), correlated positively (P < 0.05 to <0.001, age-adjusted) with parameters of adiposity, adverse lipid profiles, serum insulin, A-FABP, and C-reactive protein levels and were higher in subjects with the MetS (P < 0.001 vs. no MetS). The association of E-FABP with the MetS was independent of A-FABP. Furthermore, serum E-FABP correlated with carotid intima-media thickness (IMT; P < 0.001) and was independently associated with carotid IMT in men (adjusted P = 0.03). Conclusion: E-FABP is a new circulating biomarker associated with increased cardio-metabolic risk. It may contribute to the development of the MetS and carotid atherosclerosis in humans, independent of the effect of A-FABP. © The Author 2008.
ISSN0195-668X
2011 Impact Factor: 10.478
2011 SCImago Journal Rankings: 0.801
DOIhttp://dx.doi.org/10.1093/eurheartj/ehn295
ISI Accession Number IDWOS:000258862700018
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7404/ 04M
7590/06M
Funding Information:

This study was supported by the Hong Kong Research Grant Council (HKU7404/ 04M and 7590/ 06M to K. S. L. L.) and the matching funding for China National 973 basic research project to A. X.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYeung, DCY
dc.contributor.authorWang, Y
dc.contributor.authorXu, A
dc.contributor.authorCheung, SCW
dc.contributor.authorWat, NMS
dc.contributor.authorFong, DYT
dc.contributor.authorFong, CHY
dc.contributor.authorChau, MT
dc.contributor.authorSham, PC
dc.contributor.authorLam, KSL
dc.date.accessioned2010-05-31T03:44:20Z
dc.date.available2010-05-31T03:44:20Z
dc.date.issued2008
dc.description.abstractAims: Epidermal fatty-acid-binding protein (E-FABP) is highly homologous to adipocyte FABP (A-FABP), which mediates obesity-related metabolic syndrome (MetS), diabetes and atherosclerosis in animals. Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans. Methods and results: The presence of E-FABP in human plasma was detected by tandem mass spectrometry. Serum E-FABP levels, determined by an enzyme-linked immunosorbent assay in 479 Chinese subjects (age: 55.4 ± 13.5 years; M/F: 232/247), correlated positively (P < 0.05 to <0.001, age-adjusted) with parameters of adiposity, adverse lipid profiles, serum insulin, A-FABP, and C-reactive protein levels and were higher in subjects with the MetS (P < 0.001 vs. no MetS). The association of E-FABP with the MetS was independent of A-FABP. Furthermore, serum E-FABP correlated with carotid intima-media thickness (IMT; P < 0.001) and was independently associated with carotid IMT in men (adjusted P = 0.03). Conclusion: E-FABP is a new circulating biomarker associated with increased cardio-metabolic risk. It may contribute to the development of the MetS and carotid atherosclerosis in humans, independent of the effect of A-FABP. © The Author 2008.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationEuropean Heart Journal, 2008, v. 29 n. 17, p. 2156-2163 [How to Cite?]
DOI: http://dx.doi.org/10.1093/eurheartj/ehn295
dc.identifier.doihttp://dx.doi.org/10.1093/eurheartj/ehn295
dc.identifier.epage2163
dc.identifier.hkuros152080
dc.identifier.isiWOS:000258862700018
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7404/ 04M
7590/06M
Funding Information:

This study was supported by the Hong Kong Research Grant Council (HKU7404/ 04M and 7590/ 06M to K. S. L. L.) and the matching funding for China National 973 basic research project to A. X.

dc.identifier.issn0195-668X
2011 Impact Factor: 10.478
2011 SCImago Journal Rankings: 0.801
dc.identifier.issue17
dc.identifier.openurl
dc.identifier.pmid18603624
dc.identifier.scopuseid_2-s2.0-50849107871
dc.identifier.spage2156
dc.identifier.urihttp://hdl.handle.net/10722/59175
dc.identifier.volume29
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofEuropean Heart Journal
dc.relation.referencesReferences in Scopus
dc.rightsEuropean Heart Journal. Copyright © Oxford University Press.
dc.subject.meshAdiposity - physiology
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBiological Markers - blood
dc.subject.meshCarotid Artery Diseases - diagnosis
dc.subject.meshCarotid Intima-Media Thickness
dc.subject.meshFatty Acid-Binding Proteins - blood
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMetabolic Syndrome X - blood
dc.subject.meshMiddle Aged
dc.subject.meshObesity - blood
dc.subject.meshRisk Factors
dc.subjectAtherosclerosis
dc.subjectFatty-acid-binding proteins
dc.subjectMetabolic syndrome
dc.subjectObesity
dc.subjectRisk factors
dc.titleEpidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong