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Article: Epidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
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TitleEpidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
 
AuthorsYeung, DCY2 1
Wang, Y1 1
Xu, A2 1
Cheung, SCW3
Wat, NMS2
Fong, DYT1
Fong, CHY2
Chau, MT3
Sham, PC1
Lam, KSL2 1
 
KeywordsAtherosclerosis
Fatty-acid-binding proteins
Metabolic syndrome
Obesity
Risk factors
 
Issue Date2008
 
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
 
CitationEuropean Heart Journal, 2008, v. 29 n. 17, p. 2156-2163 [How to Cite?]
DOI: http://dx.doi.org/10.1093/eurheartj/ehn295
 
AbstractAims: Epidermal fatty-acid-binding protein (E-FABP) is highly homologous to adipocyte FABP (A-FABP), which mediates obesity-related metabolic syndrome (MetS), diabetes and atherosclerosis in animals. Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans. Methods and results: The presence of E-FABP in human plasma was detected by tandem mass spectrometry. Serum E-FABP levels, determined by an enzyme-linked immunosorbent assay in 479 Chinese subjects (age: 55.4 ± 13.5 years; M/F: 232/247), correlated positively (P < 0.05 to <0.001, age-adjusted) with parameters of adiposity, adverse lipid profiles, serum insulin, A-FABP, and C-reactive protein levels and were higher in subjects with the MetS (P < 0.001 vs. no MetS). The association of E-FABP with the MetS was independent of A-FABP. Furthermore, serum E-FABP correlated with carotid intima-media thickness (IMT; P < 0.001) and was independently associated with carotid IMT in men (adjusted P = 0.03). Conclusion: E-FABP is a new circulating biomarker associated with increased cardio-metabolic risk. It may contribute to the development of the MetS and carotid atherosclerosis in humans, independent of the effect of A-FABP. © The Author 2008.
 
ISSN0195-668X
2012 Impact Factor: 14.097
2012 SCImago Journal Rankings: 4.823
 
DOIhttp://dx.doi.org/10.1093/eurheartj/ehn295
 
ISI Accession Number IDWOS:000258862700018
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7404/ 04M
7590/06M
Funding Information:

This study was supported by the Hong Kong Research Grant Council (HKU7404/ 04M and 7590/ 06M to K. S. L. L.) and the matching funding for China National 973 basic research project to A. X.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYeung, DCY
 
dc.contributor.authorWang, Y
 
dc.contributor.authorXu, A
 
dc.contributor.authorCheung, SCW
 
dc.contributor.authorWat, NMS
 
dc.contributor.authorFong, DYT
 
dc.contributor.authorFong, CHY
 
dc.contributor.authorChau, MT
 
dc.contributor.authorSham, PC
 
dc.contributor.authorLam, KSL
 
dc.date.accessioned2010-05-31T03:44:20Z
 
dc.date.available2010-05-31T03:44:20Z
 
dc.date.issued2008
 
dc.description.abstractAims: Epidermal fatty-acid-binding protein (E-FABP) is highly homologous to adipocyte FABP (A-FABP), which mediates obesity-related metabolic syndrome (MetS), diabetes and atherosclerosis in animals. Combined deficiency of E-FABP and A-FABP protects against the MetS and atherosclerosis in mice. This study investigated the association of serum E-FABP with cardio-metabolic risk factors and carotid atherosclerosis in humans. Methods and results: The presence of E-FABP in human plasma was detected by tandem mass spectrometry. Serum E-FABP levels, determined by an enzyme-linked immunosorbent assay in 479 Chinese subjects (age: 55.4 ± 13.5 years; M/F: 232/247), correlated positively (P < 0.05 to <0.001, age-adjusted) with parameters of adiposity, adverse lipid profiles, serum insulin, A-FABP, and C-reactive protein levels and were higher in subjects with the MetS (P < 0.001 vs. no MetS). The association of E-FABP with the MetS was independent of A-FABP. Furthermore, serum E-FABP correlated with carotid intima-media thickness (IMT; P < 0.001) and was independently associated with carotid IMT in men (adjusted P = 0.03). Conclusion: E-FABP is a new circulating biomarker associated with increased cardio-metabolic risk. It may contribute to the development of the MetS and carotid atherosclerosis in humans, independent of the effect of A-FABP. © The Author 2008.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Heart Journal, 2008, v. 29 n. 17, p. 2156-2163 [How to Cite?]
DOI: http://dx.doi.org/10.1093/eurheartj/ehn295
 
dc.identifier.doihttp://dx.doi.org/10.1093/eurheartj/ehn295
 
dc.identifier.epage2163
 
dc.identifier.hkuros152080
 
dc.identifier.isiWOS:000258862700018
Funding AgencyGrant Number
Hong Kong Research Grant CouncilHKU7404/ 04M
7590/06M
Funding Information:

This study was supported by the Hong Kong Research Grant Council (HKU7404/ 04M and 7590/ 06M to K. S. L. L.) and the matching funding for China National 973 basic research project to A. X.

 
dc.identifier.issn0195-668X
2012 Impact Factor: 14.097
2012 SCImago Journal Rankings: 4.823
 
dc.identifier.issue17
 
dc.identifier.openurl
 
dc.identifier.pmid18603624
 
dc.identifier.scopuseid_2-s2.0-50849107871
 
dc.identifier.spage2156
 
dc.identifier.urihttp://hdl.handle.net/10722/59175
 
dc.identifier.volume29
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Heart Journal
 
dc.relation.referencesReferences in Scopus
 
dc.rightsEuropean Heart Journal. Copyright © Oxford University Press.
 
dc.subject.meshAdiposity - physiology
 
dc.subject.meshAdult
 
dc.subject.meshAged
 
dc.subject.meshBiological Markers - blood
 
dc.subject.meshCarotid Artery Diseases - diagnosis
 
dc.subject.meshCarotid Intima-Media Thickness
 
dc.subject.meshFatty Acid-Binding Proteins - blood
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshMetabolic Syndrome X - blood
 
dc.subject.meshMiddle Aged
 
dc.subject.meshObesity - blood
 
dc.subject.meshRisk Factors
 
dc.subjectAtherosclerosis
 
dc.subjectFatty-acid-binding proteins
 
dc.subjectMetabolic syndrome
 
dc.subjectObesity
 
dc.subjectRisk factors
 
dc.titleEpidermal fatty-acid-binding protein: A new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Queen Mary Hospital Hong Kong