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Article: Health-related quality of life of Southern Chinese with chronic hepatitis B infection

TitleHealth-related quality of life of Southern Chinese with chronic hepatitis B infection
Authors
Issue Date2009
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.hqlo.com/home/
Citation
Health And Quality Of Life Outcomes, 2009, v. 7 How to Cite?
AbstractBackground: Few studies have evaluated the health-related quality of life (HRQOL) of Southern Chinese with chronic hepatitis B (CHB) infection. Aim: To evaluate the HRQOL of Chinese patients at different stages of CHB infection and to find out factors associated with HRQOL. Methods: 520 Chinese adult CHB patients of whom 156 were uncomplicated, 102 had impaired liver function, 139 had cirrhosis and 123 had hepatocellular carcinoma (HCC) were interviewed with a structured questionnaire, the SF-36 Health Survey version 2 (SF-36v2), and the Chronic Liver Disease Questionnaire (CLDQ). The differences in SF-6D health preference values and SF-36v2 scores between each CHB group and Hong Kong population norms were assessed by t-test. ANOVA was used to compare the mean SF-6D health preference, SF-36v2 scores, and CLDQ scores among CHB groups. Multiple linear regressions were performed to identify determinants of HRQOL. Results: CHB patients had significantly lower SF-36v2 scores than the population norm. The SF-6D values of CHB patients with uncomplicated disease, impaired liver function, HCC and cirrhosis were 0.755, 0.745, 0.720 and 0.701, respectively, all significantly lower than the population norm of 0.787. Advanced stage of CHB illness, anti-viral treatment, bilirubin level, psychological co-morbidity, younger age and female were associated with poorer HRQOL. Conclusion: CHB infection had a negative impact on HRQOL. There was a progressive decrease in health preference values with CHB disease progression. The results can be used for the estimation of quality adjusted life years (QALYs) for CHB patients in cost effectiveness or cost utility studies. © 2009 Lam et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/59132
ISSN
2015 Impact Factor: 2.212
2015 SCImago Journal Rankings: 1.020
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, ETPen_HK
dc.contributor.authorLam, CLKen_HK
dc.contributor.authorLai, CLen_HK
dc.contributor.authorYuen, MFen_HK
dc.contributor.authorFong, DYTen_HK
dc.contributor.authorSo, TMKen_HK
dc.date.accessioned2010-05-31T03:43:30Z-
dc.date.available2010-05-31T03:43:30Z-
dc.date.issued2009en_HK
dc.identifier.citationHealth And Quality Of Life Outcomes, 2009, v. 7en_HK
dc.identifier.issn1477-7525en_HK
dc.identifier.urihttp://hdl.handle.net/10722/59132-
dc.description.abstractBackground: Few studies have evaluated the health-related quality of life (HRQOL) of Southern Chinese with chronic hepatitis B (CHB) infection. Aim: To evaluate the HRQOL of Chinese patients at different stages of CHB infection and to find out factors associated with HRQOL. Methods: 520 Chinese adult CHB patients of whom 156 were uncomplicated, 102 had impaired liver function, 139 had cirrhosis and 123 had hepatocellular carcinoma (HCC) were interviewed with a structured questionnaire, the SF-36 Health Survey version 2 (SF-36v2), and the Chronic Liver Disease Questionnaire (CLDQ). The differences in SF-6D health preference values and SF-36v2 scores between each CHB group and Hong Kong population norms were assessed by t-test. ANOVA was used to compare the mean SF-6D health preference, SF-36v2 scores, and CLDQ scores among CHB groups. Multiple linear regressions were performed to identify determinants of HRQOL. Results: CHB patients had significantly lower SF-36v2 scores than the population norm. The SF-6D values of CHB patients with uncomplicated disease, impaired liver function, HCC and cirrhosis were 0.755, 0.745, 0.720 and 0.701, respectively, all significantly lower than the population norm of 0.787. Advanced stage of CHB illness, anti-viral treatment, bilirubin level, psychological co-morbidity, younger age and female were associated with poorer HRQOL. Conclusion: CHB infection had a negative impact on HRQOL. There was a progressive decrease in health preference values with CHB disease progression. The results can be used for the estimation of quality adjusted life years (QALYs) for CHB patients in cost effectiveness or cost utility studies. © 2009 Lam et al; licensee BioMed Central Ltd.en_HK
dc.languageengen_HK
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.hqlo.com/home/en_HK
dc.relation.ispartofHealth and Quality of Life Outcomesen_HK
dc.subject.meshAdulten_HK
dc.subject.meshAgeden_HK
dc.subject.meshAnalysis of Varianceen_HK
dc.subject.meshChina - ethnologyen_HK
dc.subject.meshFemaleen_HK
dc.subject.meshHealth Status Indicatorsen_HK
dc.subject.meshHealth Surveysen_HK
dc.subject.meshHepatitis B, Chronic - psychologyen_HK
dc.subject.meshHong Kongen_HK
dc.subject.meshHumansen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiddle Ageden_HK
dc.subject.meshPsychometricsen_HK
dc.subject.meshQuality of Lifeen_HK
dc.subject.meshQuestionnairesen_HK
dc.titleHealth-related quality of life of Southern Chinese with chronic hepatitis B infectionen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, CLK: clklam@hku.hken_HK
dc.identifier.emailLai, CL: hrmelcl@hku.hken_HK
dc.identifier.emailYuen, MF: mfyuen@hku.hken_HK
dc.identifier.emailFong, DYT: dytfong@hku.hken_HK
dc.identifier.authorityLam, CLK=rp00350en_HK
dc.identifier.authorityLai, CL=rp00314en_HK
dc.identifier.authorityYuen, MF=rp00479en_HK
dc.identifier.authorityFong, DYT=rp00253en_HK
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1186/1477-7525-7-52en_HK
dc.identifier.pmid19500349-
dc.identifier.scopuseid_2-s2.0-67649842587en_HK
dc.identifier.hkuros158469en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67649842587&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.isiWOS:000268168100001-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridLam, ETP=35068220200en_HK
dc.identifier.scopusauthoridLam, CLK=24755913900en_HK
dc.identifier.scopusauthoridLai, CL=7403086396en_HK
dc.identifier.scopusauthoridYuen, MF=7102031955en_HK
dc.identifier.scopusauthoridFong, DYT=35261710300en_HK
dc.identifier.scopusauthoridSo, TMK=7005305634en_HK
dc.identifier.citeulike4758100-

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