Article: Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels

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TitleRisk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels
AuthorsYuen, MF2
Tanaka, Y1
Shinkai, N1
Poon, RT2
But, DYK2
Fong, DYT2
Fung, J2
Wong, DKH2
Yuen, JCH2
Mizokami, M1
Lai, CL2
Issue Date2008
PublisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
CitationGut, 2008, v. 57 n. 1, p. 98-102 [How to Cite?]
DOI: http://dx.doi.org/10.1136/gut.2007.119859
AbstractBackground/aim: To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. Methods: HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC and 248 HBV controls. Results: Genotype C, CP-MT, T1653, HBV DNA levels ≥4 log 10 copies/ml and cirrhosis had a higher risk for HCC compared to patients with genotype B (p = 0.001, OR 1.9), CP wild-type (WT) (p<0.001, OR 4.1), C1653 (p = 0.028, OR 2.4), HBV DNA <4 log 10 copies/ml (p = 0.003, OR 2.1) and without cirrhosis (p<0.001, OR 4.0) respectively. Multivariate analysis showed that CP-MT, T1653, HBV DNA ≥4 log 10 copies/ml and cirrhosis were independent factors for HCC (all p<0.05). A receiver operating characteristics curve showed no cut-off HBV DNA level associated with minimal chance of HCC. Patients with CP-MT and cirrhosis had a 22.2-fold increased risk of HCC compared to patients with CP-WT and without cirrhosis. Patients with CP-MT and HBV DNA levels ≥4 log 10 copies/ml had a 7.2-fold increased risk of HCC compared to patients with CP-WT and HBV DNA levels <4 log 10 copies/ml. Patients with CP-MT and T1653 had a 9.9-fold increased risk of HCC compared to patients with wild-type for both regions. Conclusions: CP-MT, T1653, HBV DNA levels ≥4 log 10 copies/ml and cirrhosis are independent factors for development of HCC. The risks increased substantially in patients having these factors in combination.
ISSN0017-5749
2011 Impact Factor: 10.111
2011 SCImago Journal Rankings: 0.883
DOIhttp://dx.doi.org/10.1136/gut.2007.119859
ISI Accession Number IDWOS:000251778400021
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYuen, MF
dc.contributor.authorTanaka, Y
dc.contributor.authorShinkai, N
dc.contributor.authorPoon, RT
dc.contributor.authorBut, DYK
dc.contributor.authorFong, DYT
dc.contributor.authorFung, J
dc.contributor.authorWong, DKH
dc.contributor.authorYuen, JCH
dc.contributor.authorMizokami, M
dc.contributor.authorLai, CL
dc.date.accessioned2010-04-12T01:39:15Z
dc.date.available2010-04-12T01:39:15Z
dc.date.issued2008
dc.description.abstractBackground/aim: To examine the risks for hepatocellular carcinoma (HCC) with respect to hepatitis B virus (HBV) genotypes, specific viral mutations (MT), serum HBV DNA levels, and cirrhosis. Methods: HBV genotypes, 1653/1753/core promoter (CP)/precore MT and HBV DNA levels were determined in 248 HBV patients with HCC and 248 HBV controls. Results: Genotype C, CP-MT, T1653, HBV DNA levels ≥4 log 10 copies/ml and cirrhosis had a higher risk for HCC compared to patients with genotype B (p = 0.001, OR 1.9), CP wild-type (WT) (p<0.001, OR 4.1), C1653 (p = 0.028, OR 2.4), HBV DNA <4 log 10 copies/ml (p = 0.003, OR 2.1) and without cirrhosis (p<0.001, OR 4.0) respectively. Multivariate analysis showed that CP-MT, T1653, HBV DNA ≥4 log 10 copies/ml and cirrhosis were independent factors for HCC (all p<0.05). A receiver operating characteristics curve showed no cut-off HBV DNA level associated with minimal chance of HCC. Patients with CP-MT and cirrhosis had a 22.2-fold increased risk of HCC compared to patients with CP-WT and without cirrhosis. Patients with CP-MT and HBV DNA levels ≥4 log 10 copies/ml had a 7.2-fold increased risk of HCC compared to patients with CP-WT and HBV DNA levels <4 log 10 copies/ml. Patients with CP-MT and T1653 had a 9.9-fold increased risk of HCC compared to patients with wild-type for both regions. Conclusions: CP-MT, T1653, HBV DNA levels ≥4 log 10 copies/ml and cirrhosis are independent factors for development of HCC. The risks increased substantially in patients having these factors in combination.
dc.description.naturepublished_or_final_version
dc.identifier.citationGut, 2008, v. 57 n. 1, p. 98-102 [How to Cite?]
DOI: http://dx.doi.org/10.1136/gut.2007.119859
dc.identifier.doihttp://dx.doi.org/10.1136/gut.2007.119859
dc.identifier.epage102
dc.identifier.hkuros130659
dc.identifier.isiWOS:000251778400021
dc.identifier.issn0017-5749
2011 Impact Factor: 10.111
2011 SCImago Journal Rankings: 0.883
dc.identifier.issue1
dc.identifier.openurl
dc.identifier.pmid17483190
dc.identifier.scopuseid_2-s2.0-38349138512
dc.identifier.spage98
dc.identifier.urihttp://hdl.handle.net/10722/57531
dc.identifier.volume57
dc.languageeng
dc.publisherBMJ Publishing Group. The Journal's web site is located at http://gut.bmjjournals.com/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofGut
dc.relation.referencesReferences in Scopus
dc.rightsGut. Copyright © B M J Publishing Group.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCarcinoma, Hepatocellular - virology
dc.subject.meshEnhancer Elements (Genetics) - genetics
dc.subject.meshHepatitis B virus - genetics
dc.subject.meshLiver Neoplasms - virology
dc.subject.meshPromoter Regions (Genetics) - genetics
dc.titleRisk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels
dc.typeArticle
Author Affiliations
  1. Nagoya City University
  2. The University of Hong Kong