Article: Variation in gene expression patterns in human gastric cancers

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TitleVariation in gene expression patterns in human gastric cancers
AuthorsChen, X2
Leung, SY1
Yuen, ST1
Chu, KM1
Ji, J3
Li, R2
Chan, ASY1
Law, S1
Troyanskaya, OG2
Wong, J1
So, S1
Botstein, D2
Brown, PO2
Issue Date2003
PublisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
CitationMolecular Biology Of The Cell, 2003, v. 14 n. 8, p. 3208-3215 [How to Cite?]
DOI: http://dx.doi.org/10.1091/mbc.E02-12-0833
AbstractGastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
ISSN1059-1524
2011 Impact Factor: 4.942
2011 SCImago Journal Rankings: 1.290
DOIhttp://dx.doi.org/10.1091/mbc.E02-12-0833
ISI Accession Number IDWOS:000184877400012
PubMed Central IDPMC181561
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChen, X
dc.contributor.authorLeung, SY
dc.contributor.authorYuen, ST
dc.contributor.authorChu, KM
dc.contributor.authorJi, J
dc.contributor.authorLi, R
dc.contributor.authorChan, ASY
dc.contributor.authorLaw, S
dc.contributor.authorTroyanskaya, OG
dc.contributor.authorWong, J
dc.contributor.authorSo, S
dc.contributor.authorBotstein, D
dc.contributor.authorBrown, PO
dc.date.accessioned2009-04-03T07:38:48Z
dc.date.available2009-04-03T07:38:48Z
dc.date.issued2003
dc.description.abstractGastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
dc.description.naturepublished_or_final_version
dc.identifier.citationMolecular Biology Of The Cell, 2003, v. 14 n. 8, p. 3208-3215 [How to Cite?]
DOI: http://dx.doi.org/10.1091/mbc.E02-12-0833
dc.identifier.citeulike3794530
dc.identifier.doihttp://dx.doi.org/10.1091/mbc.E02-12-0833
dc.identifier.epage3215
dc.identifier.hkuros78795
dc.identifier.isiWOS:000184877400012
dc.identifier.issn1059-1524
2011 Impact Factor: 4.942
2011 SCImago Journal Rankings: 1.290
dc.identifier.issue8
dc.identifier.openurl
dc.identifier.pmcidPMC181561
dc.identifier.pmid12925757
dc.identifier.scopuseid_2-s2.0-12444313589
dc.identifier.spage3208
dc.identifier.urihttp://hdl.handle.net/10722/54177
dc.identifier.volume14
dc.languageeng
dc.publisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
dc.publisher.placeUnited States
dc.relation.ispartofMolecular Biology of the Cell
dc.relation.referencesReferences in Scopus
dc.rightsMolecular Biology of the Cell. Copyright © American Society for Cell Biology.
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshAdenocarcinoma - etiology - genetics - metabolism
dc.subject.meshGene Expression Profiling
dc.subject.meshStomach Neoplasms - etiology - genetics - metabolism
dc.subject.meshHelicobacter Infections - complications
dc.subject.meshOligonucleotide Array Sequence Analysis
dc.titleVariation in gene expression patterns in human gastric cancers
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Stanford University School of Medicine
  3. Beijing Cancer Hospital