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Article: Variation in gene expression patterns in human gastric cancers
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TitleVariation in gene expression patterns in human gastric cancers
 
AuthorsChen, X2 2
Leung, SY1
Yuen, ST1
Chu, KM1
Ji, J3
Li, R2
Chan, ASY1
Law, S1
Troyanskaya, OG2
Wong, J1
So, S1
Botstein, D2
Brown, PO2 2
 
Issue Date2003
 
PublisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
 
CitationMolecular Biology Of The Cell, 2003, v. 14 n. 8, p. 3208-3215 [How to Cite?]
DOI: http://dx.doi.org/10.1091/mbc.E02-12-0833
 
AbstractGastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
 
ISSN1059-1524
2012 Impact Factor: 4.604
2012 SCImago Journal Rankings: 3.285
 
DOIhttp://dx.doi.org/10.1091/mbc.E02-12-0833
 
PubMed Central IDPMC181561
 
ISI Accession Number IDWOS:000184877400012
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, X
 
dc.contributor.authorLeung, SY
 
dc.contributor.authorYuen, ST
 
dc.contributor.authorChu, KM
 
dc.contributor.authorJi, J
 
dc.contributor.authorLi, R
 
dc.contributor.authorChan, ASY
 
dc.contributor.authorLaw, S
 
dc.contributor.authorTroyanskaya, OG
 
dc.contributor.authorWong, J
 
dc.contributor.authorSo, S
 
dc.contributor.authorBotstein, D
 
dc.contributor.authorBrown, PO
 
dc.date.accessioned2009-04-03T07:38:48Z
 
dc.date.available2009-04-03T07:38:48Z
 
dc.date.issued2003
 
dc.description.abstractGastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
 
dc.description.naturepublished_or_final_version
 
dc.identifier.citationMolecular Biology Of The Cell, 2003, v. 14 n. 8, p. 3208-3215 [How to Cite?]
DOI: http://dx.doi.org/10.1091/mbc.E02-12-0833
 
dc.identifier.citeulike3794530
 
dc.identifier.doihttp://dx.doi.org/10.1091/mbc.E02-12-0833
 
dc.identifier.epage3215
 
dc.identifier.hkuros78795
 
dc.identifier.isiWOS:000184877400012
 
dc.identifier.issn1059-1524
2012 Impact Factor: 4.604
2012 SCImago Journal Rankings: 3.285
 
dc.identifier.issue8
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC181561
 
dc.identifier.pmid12925757
 
dc.identifier.scopuseid_2-s2.0-12444313589
 
dc.identifier.spage3208
 
dc.identifier.urihttp://hdl.handle.net/10722/54177
 
dc.identifier.volume14
 
dc.languageeng
 
dc.publisherAmerican Society for Cell Biology. The Journal's web site is located at http://www.molbiolcell.org/
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMolecular Biology of the Cell
 
dc.relation.referencesReferences in Scopus
 
dc.rightsMolecular Biology of the Cell. Copyright © American Society for Cell Biology.
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshAdenocarcinoma - etiology - genetics - metabolism
 
dc.subject.meshGene Expression Profiling
 
dc.subject.meshStomach Neoplasms - etiology - genetics - metabolism
 
dc.subject.meshHelicobacter Infections - complications
 
dc.subject.meshOligonucleotide Array Sequence Analysis
 
dc.titleVariation in gene expression patterns in human gastric cancers
 
dc.typeArticle
 
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<description.abstract>Gastric cancer is the world&apos;s second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing &#8764;30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.</description.abstract>
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<subject.mesh>Adenocarcinoma - etiology - genetics - metabolism</subject.mesh>
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Author Affiliations
  1. The University of Hong Kong
  2. Stanford University School of Medicine
  3. Beijing Cancer Hospital