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Article: Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis

TitlePhospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis
Authors
Leung, SYChen, XChu, KMYuen, STMathy, JJi, JChan, ASYLi, RLaw, STroyanskaya, OGTu, IPWong, JSo, SBotstein, DBrown, PO
KeywordsDNA microarray
Gastritis
Gene expression profiling
Helicobacter
Mucosal immunity
Issue Date2002
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings of the National Academy of Sciences of the United States of America, 2002, v. 99 n. 25, p. 16203-16208 How to Cite?
DOI: http://dx.doi.org/10.1073/pnas.212646299
AbstractWe analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc Min/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/49119
ISSN
0027-8424
2021 Impact Factor: 12.779
2020 SCImago Journal Rankings: 5.011
PubMed Central ID
PMC138589
ISI Accession Number ID
WOS:000179783400069
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorLeung, SYen_HK
dc.contributor.authorChen, Xen_HK
dc.contributor.authorChu, KMen_HK
dc.contributor.authorYuen, STen_HK
dc.contributor.authorMathy, Jen_HK
dc.contributor.authorJi, Jen_HK
dc.contributor.authorChan, ASYen_HK
dc.contributor.authorLi, Ren_HK
dc.contributor.authorLaw, Sen_HK
dc.contributor.authorTroyanskaya, OGen_HK
dc.contributor.authorTu, IPen_HK
dc.contributor.authorWong, Jen_HK
dc.contributor.authorSo, Sen_HK
dc.contributor.authorBotstein, Den_HK
dc.contributor.authorBrown, POen_HK
dc.date.accessioned2008-06-12T06:34:50Z-
dc.date.available2008-06-12T06:34:50Z-
dc.date.issued2002en_HK
dc.identifier.citationProceedings of the National Academy of Sciences of the United States of America, 2002, v. 99 n. 25, p. 16203-16208en_HK
dc.identifier.issn0027-8424en_HK
dc.identifier.urihttp://hdl.handle.net/10722/49119-
dc.description.abstractWe analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing ≈30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc Min/+ (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.en_HK
dc.format.extent386 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.orgen_HK
dc.relation.ispartofProceedings of the National Academy of Sciences of the United States of Americaen_HK
dc.subjectDNA microarrayen_HK
dc.subjectGastritisen_HK
dc.subjectGene expression profilingen_HK
dc.subjectHelicobacteren_HK
dc.subjectMucosal immunityen_HK
dc.titlePhospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasisen_HK
dc.typeArticleen_HK
dc.identifier.emailLeung, SY: suetyi@hku.hken_HK
dc.identifier.emailChu, KM: chukm@hkucc.hku.hken_HK
dc.identifier.emailLaw, S: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLeung, SY=rp00359en_HK
dc.identifier.authorityChu, KM=rp00435en_HK
dc.identifier.authorityLaw, S=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_OA_fulltexten_HK
dc.identifier.doi10.1073/pnas.212646299en_HK
dc.identifier.pmid12456890en_HK
dc.identifier.pmcidPMC138589en_HK
dc.identifier.scopuseid_2-s2.0-0037059002en_HK
dc.identifier.hkuros75759-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0037059002&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue25en_HK
dc.identifier.spage16203en_HK
dc.identifier.epage16208en_HK
dc.identifier.isiWOS:000179783400069-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLeung, SY=7202044886en_HK
dc.identifier.scopusauthoridChen, X=8978110800en_HK
dc.identifier.scopusauthoridChu, KM=7402453538en_HK
dc.identifier.scopusauthoridYuen, ST=7103160927en_HK
dc.identifier.scopusauthoridMathy, J=6701808424en_HK
dc.identifier.scopusauthoridJi, J=7201362473en_HK
dc.identifier.scopusauthoridChan, ASY=7403168075en_HK
dc.identifier.scopusauthoridLi, R=7404723915en_HK
dc.identifier.scopusauthoridLaw, S=7202241293en_HK
dc.identifier.scopusauthoridTroyanskaya, OG=6602361421en_HK
dc.identifier.scopusauthoridTu, IP=35265351600en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK
dc.identifier.scopusauthoridSo, S=7102397384en_HK
dc.identifier.scopusauthoridBotstein, D=7102711191en_HK
dc.identifier.scopusauthoridBrown, PO=35414776900en_HK
dc.identifier.issnl0027-8424-

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