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Article: The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
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TitleThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
 
AuthorsChin, KT1
Zhou, HJ1 2
Wong, CM1
Lee, JMF1
Chan, CP1
Qiang, BQ2
Yuan, JG2
Ng, IOL1
Jin, DY1
 
Issue Date2005
 
PublisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
 
CitationNucleic Acids Research, 2005, v. 33 n. 6, p. 1859-1873 [How to Cite?]
DOI: http://dx.doi.org/10.1093/nar/gki332
 
AbstractWe have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding element. Interestingly, CREB-H has a putative transmembrane (TM) domain and it localizes ambiently to the endoplasmic reticulum. Proteolytic cleavage that removes the TM domain leads to nuclear translocation and activation of CREB-H. CREB-H activates the promoter of hepatic gluconeogenic enzyme phosphoenolpyruvate carboxykinase. This activation can be further stimulated by cAMP and protein kinase A. CREB-H transcript is exclusively abundant in adult liver. In contrast, the expression of CREB-H mRNA is aberrantly reduced in hepatoma tissues and cells. The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells. Taken together, our findings suggest that the liver-enriched bZIP transcription factor CREB-H is a growth suppressor that plays a role in hepatic physiology and pathology. © The Author 2005. Published by Oxford University Press. All rights reserved.
 
ISSN0305-1048
2013 Impact Factor: 8.808
 
DOIhttp://dx.doi.org/10.1093/nar/gki332
 
PubMed Central IDPMC1072803
 
ISI Accession Number IDWOS:000228398400025
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChin, KT
 
dc.contributor.authorZhou, HJ
 
dc.contributor.authorWong, CM
 
dc.contributor.authorLee, JMF
 
dc.contributor.authorChan, CP
 
dc.contributor.authorQiang, BQ
 
dc.contributor.authorYuan, JG
 
dc.contributor.authorNg, IOL
 
dc.contributor.authorJin, DY
 
dc.date.accessioned2008-06-12T06:31:33Z
 
dc.date.available2008-06-12T06:31:33Z
 
dc.date.issued2005
 
dc.description.abstractWe have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding element. Interestingly, CREB-H has a putative transmembrane (TM) domain and it localizes ambiently to the endoplasmic reticulum. Proteolytic cleavage that removes the TM domain leads to nuclear translocation and activation of CREB-H. CREB-H activates the promoter of hepatic gluconeogenic enzyme phosphoenolpyruvate carboxykinase. This activation can be further stimulated by cAMP and protein kinase A. CREB-H transcript is exclusively abundant in adult liver. In contrast, the expression of CREB-H mRNA is aberrantly reduced in hepatoma tissues and cells. The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells. Taken together, our findings suggest that the liver-enriched bZIP transcription factor CREB-H is a growth suppressor that plays a role in hepatic physiology and pathology. © The Author 2005. Published by Oxford University Press. All rights reserved.
 
dc.description.naturepublished_or_final_version
 
dc.format.extent388 bytes
 
dc.format.mimetypetext/html
 
dc.identifier.citationNucleic Acids Research, 2005, v. 33 n. 6, p. 1859-1873 [How to Cite?]
DOI: http://dx.doi.org/10.1093/nar/gki332
 
dc.identifier.citeulike161551
 
dc.identifier.doihttp://dx.doi.org/10.1093/nar/gki332
 
dc.identifier.epage1873
 
dc.identifier.hkuros98291
 
dc.identifier.hkuros159396
 
dc.identifier.isiWOS:000228398400025
 
dc.identifier.issn0305-1048
2013 Impact Factor: 8.808
 
dc.identifier.issue6
 
dc.identifier.openurl
 
dc.identifier.pmcidPMC1072803
 
dc.identifier.pmid15800215
 
dc.identifier.scopuseid_2-s2.0-17844395201
 
dc.identifier.spage1859
 
dc.identifier.urihttp://hdl.handle.net/10722/48991
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofNucleic Acids Research
 
dc.relation.referencesReferences in Scopus
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
 
dc.subject.meshCarcinoma, Hepatocellular - metabolism - pathology
 
dc.subject.meshLiver - metabolism
 
dc.subject.meshLiver Neoplasms - metabolism - pathology
 
dc.subject.meshTumor Suppressor Proteins - metabolism - physiology
 
dc.subject.meshTranscription Factors - analysis - classification - metabolism - physiology
 
dc.titleThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences