Article: The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma

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TitleThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
AuthorsChin, KT1
Zhou, HJ1 2
Wong, CM1
Lee, JMF1
Chan, CP1
Qiang, BQ2
Yuan, JG2
Ng, IOL1
Jin, DY1
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
CitationNucleic Acids Research, 2005, v. 33 n. 6, p. 1859-1873 [How to Cite?]
DOI: http://dx.doi.org/10.1093/nar/gki332
AbstractWe have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding element. Interestingly, CREB-H has a putative transmembrane (TM) domain and it localizes ambiently to the endoplasmic reticulum. Proteolytic cleavage that removes the TM domain leads to nuclear translocation and activation of CREB-H. CREB-H activates the promoter of hepatic gluconeogenic enzyme phosphoenolpyruvate carboxykinase. This activation can be further stimulated by cAMP and protein kinase A. CREB-H transcript is exclusively abundant in adult liver. In contrast, the expression of CREB-H mRNA is aberrantly reduced in hepatoma tissues and cells. The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells. Taken together, our findings suggest that the liver-enriched bZIP transcription factor CREB-H is a growth suppressor that plays a role in hepatic physiology and pathology. © The Author 2005. Published by Oxford University Press. All rights reserved.
ISSN0305-1048
2011 Impact Factor: 8.026
2011 SCImago Journal Rankings: 1.542
DOIhttp://dx.doi.org/10.1093/nar/gki332
ISI Accession Number IDWOS:000228398400025
PubMed Central IDPMC1072803
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorChin, KT
dc.contributor.authorZhou, HJ
dc.contributor.authorWong, CM
dc.contributor.authorLee, JMF
dc.contributor.authorChan, CP
dc.contributor.authorQiang, BQ
dc.contributor.authorYuan, JG
dc.contributor.authorNg, IOL
dc.contributor.authorJin, DY
dc.date.accessioned2008-06-12T06:31:33Z
dc.date.available2008-06-12T06:31:33Z
dc.date.issued2005
dc.description.abstractWe have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding element. Interestingly, CREB-H has a putative transmembrane (TM) domain and it localizes ambiently to the endoplasmic reticulum. Proteolytic cleavage that removes the TM domain leads to nuclear translocation and activation of CREB-H. CREB-H activates the promoter of hepatic gluconeogenic enzyme phosphoenolpyruvate carboxykinase. This activation can be further stimulated by cAMP and protein kinase A. CREB-H transcript is exclusively abundant in adult liver. In contrast, the expression of CREB-H mRNA is aberrantly reduced in hepatoma tissues and cells. The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells. Taken together, our findings suggest that the liver-enriched bZIP transcription factor CREB-H is a growth suppressor that plays a role in hepatic physiology and pathology. © The Author 2005. Published by Oxford University Press. All rights reserved.
dc.description.naturepublished_or_final_version
dc.format.extent388 bytes
dc.format.mimetypetext/html
dc.identifier.citationNucleic Acids Research, 2005, v. 33 n. 6, p. 1859-1873 [How to Cite?]
DOI: http://dx.doi.org/10.1093/nar/gki332
dc.identifier.citeulike161551
dc.identifier.doihttp://dx.doi.org/10.1093/nar/gki332
dc.identifier.epage1873
dc.identifier.hkuros98291
dc.identifier.hkuros159396
dc.identifier.isiWOS:000228398400025
dc.identifier.issn0305-1048
2011 Impact Factor: 8.026
2011 SCImago Journal Rankings: 1.542
dc.identifier.issue6
dc.identifier.openurl
dc.identifier.pmcidPMC1072803
dc.identifier.pmid15800215
dc.identifier.scopuseid_2-s2.0-17844395201
dc.identifier.spage1859
dc.identifier.urihttp://hdl.handle.net/10722/48991
dc.identifier.volume33
dc.languageeng
dc.publisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofNucleic Acids Research
dc.relation.referencesReferences in Scopus
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License
dc.subject.meshCarcinoma, Hepatocellular - metabolism - pathology
dc.subject.meshLiver - metabolism
dc.subject.meshLiver Neoplasms - metabolism - pathology
dc.subject.meshTumor Suppressor Proteins - metabolism - physiology
dc.subject.meshTranscription Factors - analysis - classification - metabolism - physiology
dc.titleThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences