File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: The liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma

TitleThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinoma
Authors
Issue Date2005
PublisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
Citation
Nucleic Acids Research, 2005, v. 33 n. 6, p. 1859-1873 How to Cite?
Abstract
We have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding element. Interestingly, CREB-H has a putative transmembrane (TM) domain and it localizes ambiently to the endoplasmic reticulum. Proteolytic cleavage that removes the TM domain leads to nuclear translocation and activation of CREB-H. CREB-H activates the promoter of hepatic gluconeogenic enzyme phosphoenolpyruvate carboxykinase. This activation can be further stimulated by cAMP and protein kinase A. CREB-H transcript is exclusively abundant in adult liver. In contrast, the expression of CREB-H mRNA is aberrantly reduced in hepatoma tissues and cells. The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells. Taken together, our findings suggest that the liver-enriched bZIP transcription factor CREB-H is a growth suppressor that plays a role in hepatic physiology and pathology. © The Author 2005. Published by Oxford University Press. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/48991
ISSN
2013 Impact Factor: 8.808
PubMed Central ID
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Institute of Basic Medical Sciences Chinese Academy of Medical Sciences
DC FieldValueLanguage
dc.contributor.authorChin, KTen_HK
dc.contributor.authorZhou, HJen_HK
dc.contributor.authorWong, CMen_HK
dc.contributor.authorLee, JMFen_HK
dc.contributor.authorChan, CPen_HK
dc.contributor.authorQiang, BQen_HK
dc.contributor.authorYuan, JGen_HK
dc.contributor.authorNg, IOLen_HK
dc.contributor.authorJin, DYen_HK
dc.date.accessioned2008-06-12T06:31:33Z-
dc.date.available2008-06-12T06:31:33Z-
dc.date.issued2005en_HK
dc.identifier.citationNucleic Acids Research, 2005, v. 33 n. 6, p. 1859-1873en_HK
dc.identifier.issn0305-1048en_HK
dc.identifier.urihttp://hdl.handle.net/10722/48991-
dc.description.abstractWe have previously characterized transcription factor LZIP to be a growth suppressor targeted by hepatitis C virus oncoprotein. In search of proteins closely related to LZIP, we have identified a liver-enriched transcription factor CREB-H. LZIP and CREB-H represent a new subfamily of bZIP factors. CREB-H activates transcription by binding to cAMP responsive element, box B, and ATF6-binding element. Interestingly, CREB-H has a putative transmembrane (TM) domain and it localizes ambiently to the endoplasmic reticulum. Proteolytic cleavage that removes the TM domain leads to nuclear translocation and activation of CREB-H. CREB-H activates the promoter of hepatic gluconeogenic enzyme phosphoenolpyruvate carboxykinase. This activation can be further stimulated by cAMP and protein kinase A. CREB-H transcript is exclusively abundant in adult liver. In contrast, the expression of CREB-H mRNA is aberrantly reduced in hepatoma tissues and cells. The enforced expression of CREB-H suppresses the proliferation of cultured hepatoma cells. Taken together, our findings suggest that the liver-enriched bZIP transcription factor CREB-H is a growth suppressor that plays a role in hepatic physiology and pathology. © The Author 2005. Published by Oxford University Press. All rights reserved.en_HK
dc.format.extent388 bytes-
dc.format.mimetypetext/html-
dc.languageengen_HK
dc.publisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/en_HK
dc.relation.ispartofNucleic Acids Researchen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshCarcinoma, Hepatocellular - metabolism - pathologyen_HK
dc.subject.meshLiver - metabolismen_HK
dc.subject.meshLiver Neoplasms - metabolism - pathologyen_HK
dc.subject.meshTumor Suppressor Proteins - metabolism - physiologyen_HK
dc.subject.meshTranscription Factors - analysis - classification - metabolism - physiologyen_HK
dc.titleThe liver-enriched transcription factor CREB-H is a growth suppressor protein underexpressed in hepatocellular carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=0305-1048&volume=33&issue=6&spage=1859&epage=1873&date=2005&atitle=The+liver-enriched+transcription+factor+CREB-H+is+a+growth+suppressor+protein+underexpressed+in+hepatocellular+carcinomaen_HK
dc.identifier.emailWong, CM:jackwong@pathology.hku.hken_HK
dc.identifier.emailNg, IOL:iolng@hkucc.hku.hken_HK
dc.identifier.emailJin, DY:dyjin@hkucc.hku.hken_HK
dc.identifier.authorityWong, CM=rp00231en_HK
dc.identifier.authorityNg, IOL=rp00335en_HK
dc.identifier.authorityJin, DY=rp00452en_HK
dc.description.naturepublished_or_final_versionen_HK
dc.identifier.doi10.1093/nar/gki332en_HK
dc.identifier.pmid15800215en_HK
dc.identifier.pmcidPMC1072803en_HK
dc.identifier.scopuseid_2-s2.0-17844395201en_HK
dc.identifier.hkuros98291-
dc.identifier.hkuros159396-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17844395201&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume33en_HK
dc.identifier.issue6en_HK
dc.identifier.spage1859en_HK
dc.identifier.epage1873en_HK
dc.identifier.isiWOS:000228398400025-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridChin, KT=7202995491en_HK
dc.identifier.scopusauthoridZhou, HJ=7404743611en_HK
dc.identifier.scopusauthoridWong, CM=16314668400en_HK
dc.identifier.scopusauthoridLee, JMF=36065603500en_HK
dc.identifier.scopusauthoridChan, CP=7404813842en_HK
dc.identifier.scopusauthoridQiang, BQ=7005510394en_HK
dc.identifier.scopusauthoridYuan, JG=7403401529en_HK
dc.identifier.scopusauthoridNg, IOL=7102753722en_HK
dc.identifier.scopusauthoridJin, DY=7201973614en_HK
dc.identifier.citeulike161551-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats