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Conference Paper: Effect of temporal lobe epilepsy on auditory-motor integration for vocal pitch regulation: Evidence from brain functional network analysis

TitleEffect of temporal lobe epilepsy on auditory-motor integration for vocal pitch regulation: Evidence from brain functional network analysis
Authors
Issue Date2019
PublisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269
Citation
The 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Biomedical Engineering Ranging from Wellness to Intensive Care Medicine (EMBC’19), Berlin, Germany, 23-27 July 2019, p. 3849-3853 How to Cite?
AbstractTemporal lobe epilepsy (TLE) is a medically refractory focal epilepsy associated with structural deficits. Considerable evidence has revealed that patients with TLE also exhibit deficits in functional connectivity. According to previous research, patients with TLE exhibited decreased performance in speech sound perception and auditory-motor integration for voice control, which might be related to the compromised brain network connectivity. However, the specific nature of functional connectivity within and across brain regions remains largely unknown. To answer this question, we extended previous research from examining the topological properties of the entire brain network to the intra- and inter-regional communications of different brain regions. Patients with TLE and healthy controls were recruited to perform a pitch reflex task, during which electroencephalograph (EEG) data were acquired to construct graphical brain networks. Compared with healthy controls, inter-regional and cross-hemispheric connections were reduced in patients with TLE, whose functional networks were primarily composed of intra-regional connections. Significant differences in network parameters (betweenness centrality, modularity, and functional integration) as well as network hubs between the two groups further supported our findings that TLE is associated with alterations in functional connectivity during auditory-motor integration.
DescriptionFrB01: Neurological Disorders (II) (Oral Session): no. FrB01.2
Persistent Identifierhttp://hdl.handle.net/10722/274232
ISSN

 

DC FieldValueLanguage
dc.contributor.authorWang, T-
dc.contributor.authorLiu, H-
dc.contributor.authorWang, L-
dc.contributor.authorNg, ML-
dc.contributor.authorLi, H-
dc.contributor.authorYan, N-
dc.date.accessioned2019-08-18T14:57:43Z-
dc.date.available2019-08-18T14:57:43Z-
dc.date.issued2019-
dc.identifier.citationThe 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Biomedical Engineering Ranging from Wellness to Intensive Care Medicine (EMBC’19), Berlin, Germany, 23-27 July 2019, p. 3849-3853-
dc.identifier.issn1557-170X-
dc.identifier.urihttp://hdl.handle.net/10722/274232-
dc.descriptionFrB01: Neurological Disorders (II) (Oral Session): no. FrB01.2-
dc.description.abstractTemporal lobe epilepsy (TLE) is a medically refractory focal epilepsy associated with structural deficits. Considerable evidence has revealed that patients with TLE also exhibit deficits in functional connectivity. According to previous research, patients with TLE exhibited decreased performance in speech sound perception and auditory-motor integration for voice control, which might be related to the compromised brain network connectivity. However, the specific nature of functional connectivity within and across brain regions remains largely unknown. To answer this question, we extended previous research from examining the topological properties of the entire brain network to the intra- and inter-regional communications of different brain regions. Patients with TLE and healthy controls were recruited to perform a pitch reflex task, during which electroencephalograph (EEG) data were acquired to construct graphical brain networks. Compared with healthy controls, inter-regional and cross-hemispheric connections were reduced in patients with TLE, whose functional networks were primarily composed of intra-regional connections. Significant differences in network parameters (betweenness centrality, modularity, and functional integration) as well as network hubs between the two groups further supported our findings that TLE is associated with alterations in functional connectivity during auditory-motor integration.-
dc.languageeng-
dc.publisherInstitute of Electrical and Electronics Engineers. The Journal's web site is located at https://ieeexplore.ieee.org/xpl/conhome.jsp?punumber=1000269-
dc.relation.ispartofIEEE Engineering in Medicine and Biology Society (EMBC) Conference Proceedings-
dc.rightsIEEE Engineering in Medicine and Biology Society (EMBC) Conference Proceedings. Copyright © Institute of Electrical and Electronics Engineers.-
dc.rights©2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.-
dc.titleEffect of temporal lobe epilepsy on auditory-motor integration for vocal pitch regulation: Evidence from brain functional network analysis-
dc.typeConference_Paper-
dc.identifier.emailNg, ML: manwa@hku.hk-
dc.identifier.authorityNg, ML=rp00942-
dc.identifier.doi10.1109/EMBC.2019.8856902-
dc.identifier.hkuros302049-
dc.identifier.spage3849-
dc.identifier.epage3853-
dc.publisher.placeUnited States-

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