File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: A territorywide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong

TitleA territorywide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong
Authors
KeywordsHBV
HCV
Vaccination
Immigration
HAV
HEV
Issue Date2019
PublisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org
Citation
The Journal of Infectious Diseases, 2019 How to Cite?
AbstractBackground: Viral hepatitis epidemiological data are important for the World Health Organization plan of eliminating viral hepatitis. We aimed to document the prevalence of viral hepatitis A to E in Hong Kong. Methods: This community-based study was open to all Hong Kong Chinese citizens aged ≥18 years. Baseline data and risk factors were collected. Hepatitis A–E serology was measured, including hepatitis B e antigen, antibodies to hepatitis B e antigen, antibodies to hepatitis D, hepatitis B virus (HBV) DNA for hepatitis B surface antigen (HBsAg)–positive participants, and antibodies to hepatitis B surface antigen and antibodies to hepatitis B core antigen (anti-HBc) in HBsAg-negative participants. Hepatitis C virus (HCV) RNA and genotypes were determined in anti-HCV–positive participants. Results: A total of 10 256 participants were recruited from February 2015 to July 2016. Overall HBsAg seroprevalence was 7.8% (95% confidence interval [CI], 7.3%–8.3%), which was reduced significantly with HBV vaccination (odds ratio, 0.15 [95% CI, .11–.21]). Among HBsAg-negative participants, anti-HBc seroprevalence increased from 5.4% (<26 years) to 60.1% (>65 years). No hepatitis D virus (HDV) cases were detected. Anti-HCV positivity was 0.5% (95% CI, .3%–.6%). Prevalence of antibodies to hepatitis A virus (anti-HAV) and hepatitis E virus (anti-HEV) was 65.2% (95% CI, 64.2%–66.1%) and 33.3% (95% CI, 32.4%–34.2%), respectively, and were influenced by age, family income, and being born in mainland China. Conclusions: HBV seroprevalence remained high despite universal vaccination. High anti-HBc seroprevalence underlines the potential issue of HBV reactivation during profound immunosuppression. HCV and HDV remained uncommon. Anti-HAV seroprevalence had decreased whereas anti-HEV seroprevalence had risen.
Persistent Identifierhttp://hdl.handle.net/10722/267336
ISSN
2017 Impact Factor: 5.186
2015 SCImago Journal Rankings: 4.000

 

DC FieldValueLanguage
dc.contributor.authorLiu, SHK-
dc.contributor.authorSeto, WKW-
dc.contributor.authorLau, EHY-
dc.contributor.authorWong, DKH-
dc.contributor.authorLam, YF-
dc.contributor.authorCheung, KSM-
dc.contributor.authorMak, LY-
dc.contributor.authorKo, KL-
dc.contributor.authorTo, WP-
dc.contributor.authorLaw, MWK-
dc.contributor.authorWu, JTK-
dc.contributor.authorLai, CL-
dc.contributor.authorYuen, RMF-
dc.date.accessioned2019-02-18T08:59:53Z-
dc.date.available2019-02-18T08:59:53Z-
dc.date.issued2019-
dc.identifier.citationThe Journal of Infectious Diseases, 2019-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/267336-
dc.description.abstractBackground: Viral hepatitis epidemiological data are important for the World Health Organization plan of eliminating viral hepatitis. We aimed to document the prevalence of viral hepatitis A to E in Hong Kong. Methods: This community-based study was open to all Hong Kong Chinese citizens aged ≥18 years. Baseline data and risk factors were collected. Hepatitis A–E serology was measured, including hepatitis B e antigen, antibodies to hepatitis B e antigen, antibodies to hepatitis D, hepatitis B virus (HBV) DNA for hepatitis B surface antigen (HBsAg)–positive participants, and antibodies to hepatitis B surface antigen and antibodies to hepatitis B core antigen (anti-HBc) in HBsAg-negative participants. Hepatitis C virus (HCV) RNA and genotypes were determined in anti-HCV–positive participants. Results: A total of 10 256 participants were recruited from February 2015 to July 2016. Overall HBsAg seroprevalence was 7.8% (95% confidence interval [CI], 7.3%–8.3%), which was reduced significantly with HBV vaccination (odds ratio, 0.15 [95% CI, .11–.21]). Among HBsAg-negative participants, anti-HBc seroprevalence increased from 5.4% (<26 years) to 60.1% (>65 years). No hepatitis D virus (HDV) cases were detected. Anti-HCV positivity was 0.5% (95% CI, .3%–.6%). Prevalence of antibodies to hepatitis A virus (anti-HAV) and hepatitis E virus (anti-HEV) was 65.2% (95% CI, 64.2%–66.1%) and 33.3% (95% CI, 32.4%–34.2%), respectively, and were influenced by age, family income, and being born in mainland China. Conclusions: HBV seroprevalence remained high despite universal vaccination. High anti-HBc seroprevalence underlines the potential issue of HBV reactivation during profound immunosuppression. HCV and HDV remained uncommon. Anti-HAV seroprevalence had decreased whereas anti-HEV seroprevalence had risen.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://jid.oxfordjournals.org-
dc.relation.ispartofThe Journal of Infectious Diseases-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Infectious Diseases following peer review. The definitive publisher-authenticated version is available online at: http://dx.doi.org/10.1093/infdis/jiz038.-
dc.subjectHBV-
dc.subjectHCV-
dc.subjectVaccination-
dc.subjectImmigration-
dc.subjectHAV-
dc.subjectHEV-
dc.titleA territorywide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong-
dc.typeArticle-
dc.identifier.emailLiu, SHK: drkliu@hku.hk-
dc.identifier.emailSeto, WKW: wkseto@hku.hk-
dc.identifier.emailLau, EHY: ehylau@hku.hk-
dc.identifier.emailWong, DKH: danywong@hku.hk-
dc.identifier.emailLam, YF: fyflam@hku.hk-
dc.identifier.emailCheung, KSM: cks634@hku.hk-
dc.identifier.emailWu, JTK: joewu@hku.hk-
dc.identifier.emailLai, CL: hrmelcl@hkucc.hku.hk-
dc.identifier.emailYuen, RMF: mfyuen@hku.hk-
dc.identifier.authoritySeto, WKW=rp01659-
dc.identifier.authorityLau, EHY=rp01349-
dc.identifier.authorityWong, DKH=rp00492-
dc.identifier.authorityCheung, KSM=rp02532-
dc.identifier.authorityWu, JTK=rp00517-
dc.identifier.authorityLai, CL=rp00314-
dc.identifier.authorityYuen, RMF=rp00479-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1093/infdis/jiz038-
dc.identifier.pmid30668746-
dc.identifier.hkuros296832-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats