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Article: Serum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome

TitleSerum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome
Authors
Issue Date2016
Citation
Gynecological Endocrinology, 2016, v. 32, p. 390-394 How to Cite?
AbstractOBJECTIVE: To evaluate the association of serum adiponectin level with the metabolic syndrome in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a cross-sectional study carried out in Hong Kong Chinese women with PCOS at a university-affiliated tertiary hospital between January 2010 and January 2011. Clinical and biochemical parameters of the women were analysed. Prediction of the metabolic syndrome was determined by receiver-operator characteristic (ROC) curves, univariate and multivariate logistic regression analyses. RESULTS: A total of 116 women diagnosed to have PCOS were analysed. The area under the ROC curve of adiponectin for the prediction of metabolic syndrome was 0.820, 95% confidence interval (CI) 0.737-0.886. Univariate binary logistic regression showed that testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), waist circumference, body mass index (BMI), quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment of insulin resistance (HOMA-IR) and adiponectin were significantly associated with the metabolic syndrome. On multivariate logistic regression analysis, adiponectin (p =  0.020), HOMA-IR, age (p =  0.011) and BMI (p =  0.019) were independently associated with the metabolic syndrome, but not FAI (p =  0.256). CONCLUSIONS: Serum adiponectin is independently associated with the metabolic syndrome in Chinese women with PCOS. Further longitudinal follow-up studies are needed to determine whether serum adiponectin adds to the prediction of long-term cardiometabolic morbidity conferred by age, BMI and measures of insulin resistance.
Persistent Identifierhttp://hdl.handle.net/10722/234067

 

DC FieldValueLanguage
dc.contributor.authorKo, KYJ-
dc.contributor.authorLi, RHW-
dc.contributor.authorLam, KSL-
dc.contributor.authorTam, S-
dc.contributor.authorLee, VCY-
dc.contributor.authorYeung, TWY-
dc.contributor.authorHo, PC-
dc.contributor.authorNg, EHY-
dc.date.accessioned2016-10-14T06:58:51Z-
dc.date.available2016-10-14T06:58:51Z-
dc.date.issued2016-
dc.identifier.citationGynecological Endocrinology, 2016, v. 32, p. 390-394-
dc.identifier.urihttp://hdl.handle.net/10722/234067-
dc.description.abstractOBJECTIVE: To evaluate the association of serum adiponectin level with the metabolic syndrome in Chinese women with polycystic ovary syndrome (PCOS). METHODS: This was a cross-sectional study carried out in Hong Kong Chinese women with PCOS at a university-affiliated tertiary hospital between January 2010 and January 2011. Clinical and biochemical parameters of the women were analysed. Prediction of the metabolic syndrome was determined by receiver-operator characteristic (ROC) curves, univariate and multivariate logistic regression analyses. RESULTS: A total of 116 women diagnosed to have PCOS were analysed. The area under the ROC curve of adiponectin for the prediction of metabolic syndrome was 0.820, 95% confidence interval (CI) 0.737-0.886. Univariate binary logistic regression showed that testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), waist circumference, body mass index (BMI), quantitative insulin-sensitivity check index (QUICKI), homeostasis model assessment of insulin resistance (HOMA-IR) and adiponectin were significantly associated with the metabolic syndrome. On multivariate logistic regression analysis, adiponectin (p =  0.020), HOMA-IR, age (p =  0.011) and BMI (p =  0.019) were independently associated with the metabolic syndrome, but not FAI (p =  0.256). CONCLUSIONS: Serum adiponectin is independently associated with the metabolic syndrome in Chinese women with PCOS. Further longitudinal follow-up studies are needed to determine whether serum adiponectin adds to the prediction of long-term cardiometabolic morbidity conferred by age, BMI and measures of insulin resistance.-
dc.languageeng-
dc.relation.ispartofGynecological Endocrinology-
dc.titleSerum adiponectin is independently associated with the metabolic syndrome in Hong Kong, Chinese women with polycystic ovary syndrome-
dc.typeArticle-
dc.identifier.emailKo, KYJ: jenko@hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.emailLam, KSL: ksllam@hku.hk-
dc.identifier.emailTam, S: stam@hkucc.hku.hk-
dc.identifier.emailLee, VCY: v200lee@hku.hk-
dc.identifier.emailYeung, TWY: twyyeung@hku.hk-
dc.identifier.emailHo, PC: pcho@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.authorityLi, RHW=rp01649-
dc.identifier.authorityLam, KSL=rp00343-
dc.identifier.authorityHo, PC=rp00325-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.doi10.3109/09513590.2015.1126708-
dc.identifier.hkuros267396-
dc.identifier.volume32-
dc.identifier.spage390-
dc.identifier.epage394-

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