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Article: Treatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study

TitleTreatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study
Authors
Issue Date2015
PublisherHGE Update Medical Publishing S.A. The Journal's web site is located at http://www.thieme.de/hepato/index.html
Citation
Hepato-Gastroenterology, 2015, v. 62 n. 139, p. 748-751 How to Cite?
AbstractBACKGROUND/AIMS: Patients with gastric intestinal metaplasia and dysplasia are at increased risk of gastric cancer development. We tested the feasibility of using endoscopic radiofrequency ablation for the treatment of dysplasia and metaplasia in the stomach. METHODOLOGY: Patients who had histologically confirmed low-grade gastric dysplasia or IM were recruited. Endoscopic RFA was performed at 8 week-intervals for a maximum of 3 sessions. All patients were followed up by endoscopy until 12 months post-RFA. The primary outcome was the complete eradication of dysplasia or IM on follow-up. Secondary outcome was adverse events related to RFA. RESULTS: A total of 12 patients were recruited. Four patients had low-grade dysplasia and the remaining 8 patients had non-dysplastic IM at baseline. At one year after RFA, complete eradication of dysplasia was noted in four patients with low-grade dysplasia (100%). Gastric IM persisted in all patients with baseline metaplasia but the severity of IM improved in 6 (75%) patients. Endoscopic RFA was safe with minimal complications encountered. CONCLUSIONS: RFA successfully eradicated low-grade dysplasia of the stomach. Gastric IM however persisted after RFA but most patients had evidence of histological improvement on follow up. TRIAL REGISTRATION: ClinicalTrials.gov NCT01614418.
Persistent Identifierhttp://hdl.handle.net/10722/226335
ISSN
2015 Impact Factor: 0.792
2015 SCImago Journal Rankings: 0.446

 

DC FieldValueLanguage
dc.contributor.authorLeung, WK-
dc.contributor.authorTong, DKH-
dc.contributor.authorLeung, SY-
dc.contributor.authorChan, FSY-
dc.contributor.authorTong, TSM-
dc.contributor.authorHo, RSL-
dc.contributor.authorChu, KM-
dc.contributor.authorLaw, SYK-
dc.date.accessioned2016-06-17T07:43:26Z-
dc.date.available2016-06-17T07:43:26Z-
dc.date.issued2015-
dc.identifier.citationHepato-Gastroenterology, 2015, v. 62 n. 139, p. 748-751-
dc.identifier.issn0172-6390-
dc.identifier.urihttp://hdl.handle.net/10722/226335-
dc.description.abstractBACKGROUND/AIMS: Patients with gastric intestinal metaplasia and dysplasia are at increased risk of gastric cancer development. We tested the feasibility of using endoscopic radiofrequency ablation for the treatment of dysplasia and metaplasia in the stomach. METHODOLOGY: Patients who had histologically confirmed low-grade gastric dysplasia or IM were recruited. Endoscopic RFA was performed at 8 week-intervals for a maximum of 3 sessions. All patients were followed up by endoscopy until 12 months post-RFA. The primary outcome was the complete eradication of dysplasia or IM on follow-up. Secondary outcome was adverse events related to RFA. RESULTS: A total of 12 patients were recruited. Four patients had low-grade dysplasia and the remaining 8 patients had non-dysplastic IM at baseline. At one year after RFA, complete eradication of dysplasia was noted in four patients with low-grade dysplasia (100%). Gastric IM persisted in all patients with baseline metaplasia but the severity of IM improved in 6 (75%) patients. Endoscopic RFA was safe with minimal complications encountered. CONCLUSIONS: RFA successfully eradicated low-grade dysplasia of the stomach. Gastric IM however persisted after RFA but most patients had evidence of histological improvement on follow up. TRIAL REGISTRATION: ClinicalTrials.gov NCT01614418.-
dc.languageeng-
dc.publisherHGE Update Medical Publishing S.A. The Journal's web site is located at http://www.thieme.de/hepato/index.html-
dc.relation.ispartofHepato-Gastroenterology-
dc.titleTreatment of Gastric Metaplasia or Dysplasia by Endoscopic Radiofrequency Ablation: A Pilot Study-
dc.typeArticle-
dc.identifier.emailLeung, WK: waikleung@hku.hk-
dc.identifier.emailTong, DKH: esodtong@hku.hk-
dc.identifier.emailLeung, SY: suetyi@hku.hk-
dc.identifier.emailChan, FSY: fsychan@hku.hk-
dc.identifier.emailTong, TSM: tongsma@hkucc.hku.hk-
dc.identifier.emailHo, RSL: hsl388@hku.hk-
dc.identifier.emailChu, KM: chukm@hkucc.hku.hk-
dc.identifier.emailLaw, SYK: slaw@hkucc.hku.hk-
dc.identifier.authorityLeung, WK=rp01479-
dc.identifier.authorityLeung, SY=rp00359-
dc.identifier.authorityChu, KM=rp00435-
dc.identifier.authorityLaw, SYK=rp00437-
dc.identifier.pmid26897966-
dc.identifier.hkuros258125-
dc.identifier.hkuros243225-
dc.identifier.hkuros263793-
dc.identifier.volume62-
dc.identifier.issue139-
dc.identifier.spage748-
dc.identifier.epage751-
dc.publisher.placeGreece-

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