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  Patent History
  • Application
    CN 2010808828 2010-02-18
  • Publication
    CN 102341132 2012-02-01

Patent: Antibacterial surface and method of fabrication

TitleAntibacterial surface and method of fabrication
Priority Date2010-02-18 PCT/CN2010000216
2009-02-19 US 12/153840P
2009-02-20 US 12/154278P
Inventors
Issue Date2012
Citation
China Published Patent Application CN 102341132. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2012 How to Cite?
AbstractThis invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.
Persistent Identifierhttp://hdl.handle.net/10722/210550

 

DC FieldValueLanguage
dc.date.accessioned2015-06-17T07:04:27Z-
dc.date.available2015-06-17T07:04:27Z-
dc.date.issued2012-
dc.identifier.citationChina Published Patent Application CN 102341132. Beijing, PRC: State Intellectual Property Office (SIPO) of the P.R.C., 2012-
dc.identifier.urihttp://hdl.handle.net/10722/210550-
dc.description.abstractThis invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License for public patent documents-
dc.titleAntibacterial surface and method of fabrication-
dc.typePatent-
dc.identifier.authorityKAO YITSUN RICHARD=rp00481-
dc.identifier.authorityYEUNG WAIKWOK KELVIN=rp00309-
dc.identifier.authorityCHEUNG MANCHEE=rp00387-
dc.identifier.authorityLUK DIPKEI KEITH=rp00333-
dc.description.naturepublished_or_final_version-
dc.contributor.inventorCHEUNG MANCHEE-
dc.contributor.inventorCHU KIMHO PAUL-
dc.contributor.inventorKAO YITSUN RICHARD-
dc.contributor.inventorLUK DIPKEI KEITH-
dc.contributor.inventorYEUNG CHEYAN-
dc.contributor.inventorYEUNG WAIKWOK KELVIN-
patents.identifier.applicationCN 2010808828-
patents.identifier.applicationZL201080008828.1-
patents.description.assigneeVERSITECH LTD; UNIV CITY HONG KONG-
patents.description.countryChina, PRC-
patents.date.publication2012-02-01-
patents.identifier.hkutechidO&T-2009-00305-2-
patents.identifier.hkutechidO&T-2009-00305-6-
patents.date.application2010-02-18-
patents.date.priority2010-02-18 PCT/CN2010000216-
patents.date.priority2009-02-19 US 12/153840P-
patents.date.priority2009-02-20 US 12/154278P-
patents.description.cccn-
patents.identifier.publicationCN 102341132-
patents.relation.familyUS 2011046747 (A1) 2011-02-24-
patents.relation.familyWO 2010094212 (A2) 2010-08-26-
patents.relation.familyEP 2398517 (A2) 2011-12-28-
patents.description.kindA-

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