Published Patent: ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
| Title | ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION |
|---|---|
| Priority Date | 2009-02-19 US 12/153840P 2009-02-20 US 12/154278P |
| Inventors | Yeung, KWK Cheung, KMC Luk, KDK Yeung, CY Kao, RYT Chu, PK |
| Issue Date | 2010 |
| Citation | WO Published patent application WO 2010094212. World Intellectual Property Organization (WIPO), PatentScope, 2010 [How to Cite?] |
| Abstract | This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule. |
| References | CN 1933859 (A) 2007-03-21 CN 100594947 (C) 2010-03-24 CN 101128224 (A) 2008-02-20 CN 101020087 (A) 2007-08-22 CN 100579588 (C) 2010-01-13 |
| dc.contributor.inventor | Yeung, KWK |
|---|---|
| dc.contributor.inventor | Cheung, KMC |
| dc.contributor.inventor | Luk, KDK |
| dc.contributor.inventor | Yeung, CY |
| dc.contributor.inventor | Kao, RYT |
| dc.contributor.inventor | Chu, PK |
| dc.date.accessioned | 2010-10-31T12:42:22Z |
| patents.date.application | 2010-02-18 |
| dc.date.available | 2010-10-31T12:42:22Z |
| dc.date.issued | 2010 |
| patents.date.priority | 2009-02-19 US 12/153840P |
| patents.date.priority | 2009-02-20 US 12/154278P |
| patents.date.publication | 2010-08-26 |
| dc.description.abstract | This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule. |
| patents.description.assignee | VERSITECH LTD [CN]; UNIV CITY HONG KONG [CN]; YEUNG WAIKWOK KELVIN [CN]; CHEUNG MANCHEE [CN]; LUK DIPKEI KEITH [CN]; YEUNG CHEYAN [CN]; KAO YITSUN RICHARD [CN]; CHU KIMHO PAUL [CN] |
| patents.description.cc | WO |
| patents.description.country | World Intellectual Property Organization (WIPO) |
| patents.description.kind | A2 |
| patents.identifier.application | PC T/CN2010000216 |
| dc.identifier.citation | WO Published patent application WO 2010094212. World Intellectual Property Organization (WIPO), PatentScope, 2010 [How to Cite?] |
| dc.identifier.hkuros | 180221 |
| patents.identifier.publication | WO 2010094212 |
| dc.identifier.uri | http://hdl.handle.net/10722/126682 |
| dc.language | eng |
| patents.relation.family | CN 102341132 (A) 2012-02-01 |
| patents.relation.family | EP 2398517 (A2) 2011-12-28 |
| patents.relation.family | US 2011046747 (A1) 2011-02-24 |
| dc.relation.references | CN 1933859 (A) 2007-03-21 |
| dc.relation.references | CN 100594947 (C) 2010-03-24 |
| dc.relation.references | CN 101128224 (A) 2008-02-20 |
| dc.relation.references | CN 101020087 (A) 2007-08-22 |
| dc.relation.references | CN 100579588 (C) 2010-01-13 |
| dc.rights | Creative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents |
| dc.title | ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION |
| dc.type | Patent |
| patents.type | Patent_published |