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Patent History
  • Application
    PC T/CN2010000216 2010-02-18
  • Publication
    WO 2010094212 2010-08-26
 
Supplementary

Published Patent: ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
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TitleANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
 
Priority Date2009-02-19 US 12/153840P
2009-02-20 US 12/154278P
 
InventorsYeung, KWK
Cheung, KMC
Luk, KDK
Yeung, CY
Kao, RYT
Chu, PK
 
Issue Date2010
 
CitationWO Published patent application WO 2010094212. World Intellectual Property Organization (WIPO), PatentScope, 2010 [How to Cite?]
 
AbstractThis invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.
 
ReferencesCN 1933859 (A) 2007-03-21

CN 100594947 (C) 2010-03-24

CN 101128224 (A) 2008-02-20

CN 101020087 (A) 2007-08-22

CN 100579588 (C) 2010-01-13
 
DC FieldValue
dc.contributor.inventorYeung, KWK
 
dc.contributor.inventorCheung, KMC
 
dc.contributor.inventorLuk, KDK
 
dc.contributor.inventorYeung, CY
 
dc.contributor.inventorKao, RYT
 
dc.contributor.inventorChu, PK
 
dc.date.accessioned2010-10-31T12:42:22Z
 
patents.date.application2010-02-18
 
dc.date.available2010-10-31T12:42:22Z
 
dc.date.issued2010
 
patents.date.priority2009-02-19 US 12/153840P
 
patents.date.priority2009-02-20 US 12/154278P
 
patents.date.publication2010-08-26
 
dc.description.abstractThis invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.
 
patents.description.assigneeVERSITECH LTD [CN]; UNIV CITY HONG KONG [CN]; YEUNG WAIKWOK KELVIN [CN]; CHEUNG MANCHEE [CN]; LUK DIPKEI KEITH [CN]; YEUNG CHEYAN [CN]; KAO YITSUN RICHARD [CN]; CHU KIMHO PAUL [CN]
 
patents.description.ccWO
 
patents.description.countryWorld Intellectual Property Organization (WIPO)
 
patents.description.kindA2
 
dc.description.naturepublished_or_final_version
 
patents.identifier.applicationPC T/CN2010000216
 
dc.identifier.citationWO Published patent application WO 2010094212. World Intellectual Property Organization (WIPO), PatentScope, 2010 [How to Cite?]
 
dc.identifier.hkuros180221
 
patents.identifier.publicationWO 2010094212
 
dc.identifier.urihttp://hdl.handle.net/10722/126682
 
dc.languageeng
 
patents.relation.familyCN 102341132 (A) 2012-02-01
 
patents.relation.familyEP 2398517 (A2) 2011-12-28
 
patents.relation.familyUS 2011046747 (A1) 2011-02-24
 
dc.relation.referencesCN 1933859 (A) 2007-03-21
 
dc.relation.referencesCN 100594947 (C) 2010-03-24
 
dc.relation.referencesCN 101128224 (A) 2008-02-20
 
dc.relation.referencesCN 101020087 (A) 2007-08-22
 
dc.relation.referencesCN 100579588 (C) 2010-01-13
 
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents
 
dc.titleANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
 
dc.typePatent
 
patents.typePatent_published
 
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<description.abstract>This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&amp;D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.</description.abstract>
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