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  Patent History
  • Application
    PC T/CN2010000216 2010-02-18
  • Publication
    WO 2010094212 2010-08-26
Supplementary

published patent: ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION

TitleANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
Priority Date2009-02-19 US 12/153840P
2009-02-20 US 12/154278P
Inventors
Issue Date2010
Citation
WO Published patent application WO 2010094212. World Intellectual Property Organization (WIPO), PatentScope, 2010 How to Cite?
AbstractThis invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.
Persistent Identifierhttp://hdl.handle.net/10722/126682
References

 

DC FieldValueLanguage
dc.date.accessioned2010-10-31T12:42:22Z-
dc.date.available2010-10-31T12:42:22Z-
dc.date.issued2010en_HK
dc.identifier.citationWO Published patent application WO 2010094212. World Intellectual Property Organization (WIPO), PatentScope, 2010en_HK
dc.identifier.urihttp://hdl.handle.net/10722/126682-
dc.description.abstractThis invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.; An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.en_HK
dc.languageengen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License For Public Patent Documents-
dc.titleANTIBACTERIAL SURFACE AND METHOD OF FABRICATIONen_HK
dc.typePatenten_HK
dc.identifier.emailYeung, KWK: wkkyeung@hkucc.hku.hken_HK
dc.identifier.emailCheung, KMC: cheungmc@hku.hken_HK
dc.identifier.emailLuk, KDK: hrmoldk@hkucc.hku.hken_HK
dc.identifier.emailYeung, CY: sheepyyan@gmail.comen_HK
dc.identifier.emailKao, RYT: rytkao@hkucc.hku.hken_HK
dc.identifier.authorityYeung, KWK=rp00309en_HK
dc.identifier.authorityCheung, KMC=rp00387en_HK
dc.identifier.authorityLuk, KDK=rp00333en_HK
dc.identifier.authorityKao, RYT=rp00481en_HK
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros180221en_HK
dc.contributor.inventorYeung, KWKen_HK
dc.contributor.inventorCheung, KMCen_HK
dc.contributor.inventorLuk, KDKen_HK
dc.contributor.inventorYeung, CYen_HK
dc.contributor.inventorKao, RYTen_HK
dc.contributor.inventorChu, PKen_HK
patents.identifier.applicationPC T/CN2010000216en_HK
patents.description.assigneeVERSITECH LTD [CN]; UNIV CITY HONG KONG [CN]; YEUNG WAIKWOK KELVIN [CN]; CHEUNG MANCHEE [CN]; LUK DIPKEI KEITH [CN]; YEUNG CHEYAN [CN]; KAO YITSUN RICHARD [CN]; CHU KIMHO PAUL [CN]en_HK
patents.description.countryWorld Intellectual Property Organization (WIPO)en_HK
patents.date.publication2010-08-26en_HK
dc.relation.referencesCN 1933859 (A) 2007-03-21en_HK
dc.relation.referencesCN 100594947 (C) 2010-03-24en_HK
dc.relation.referencesCN 101128224 (A) 2008-02-20en_HK
dc.relation.referencesCN 101020087 (A) 2007-08-22en_HK
dc.relation.referencesCN 100579588 (C) 2010-01-13en_HK
patents.date.application2010-02-18en_HK
patents.date.priority2009-02-19 US 12/153840Pen_HK
patents.date.priority2009-02-20 US 12/154278Pen_HK
patents.description.ccWOen_HK
patents.identifier.publicationWO 2010094212en_HK
patents.relation.familyCN 102341132 (A) 2012-02-01en_HK
patents.relation.familyEP 2398517 (A2) 2011-12-28en_HK
patents.relation.familyUS 2011046747 (A1) 2011-02-24en_HK
patents.description.kindA2en_HK
patents.typePatent_publisheden_HK

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