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Conference Paper: Causes of death in patients with severe lupus nephritis

TitleCauses of death in patients with severe lupus nephritis
Authors
Issue Date2010
PublisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP
Citation
The 12th Asian Pacific Congress of Nephrology (APCN 2010) in conjunction with 4th Asian Forum of CKD Initiative & Korea-Japan HDF Forum, Seoul, Korea, 5-8 June 2010. In Nephrology, 2010, v. 15 suppl. 3, p. 44, abstract no. FP05-10 How to Cite?
AbstractINTRODUCTION: Improvements in immunosuppression and medical care have brought about changes in the clinical outcome of patients with lupus nephritis. We investigated the causes and the mortality risk factors of these patients in the present era. METHODS: This was a retrospective study of all patients followed in a lupus nephritis clinic since January 1971. The causes of death were identifi ed and the standardized mortality ratios (SMR) of potential risk factors were calculated with reference to the local general population. RESULTS: 287 Chinese patients were included. The follow-up was 5164.1 personyears (mean 18.0 ± 8.4 years). 230 patients (80.1%) had a history of Class III/IV ± V renal involvement. 27 patients (9.4%) died during follow-up. The 5-, 10-, and 20-year patient survival rates were 98.9%, 98.1% and 90.9% respectively, while corresponding renal survival rates were 98.6%, 96.6% and 85.3% respectively. The leading causes of death were infection (44.8%), malignancy (20.7%) and cardiovascular disease (17.2%). The overall SMR was 6.3, while that associated with renal involvement, endstage renal failure, malignancy, and cardiovascular disease was 6.4, 26.1, 13.0, and 11.4 respectively. CONCLUSION: Lupus nephritis is associated with a 6.4-fold increase in the risk of death compared with the general population, and lupus patients who develop endstage renal failure have a 26-fold excess in the risk of death.
DescriptionOral Abstracts - Free Paper Session 05: no. FP05-10
This free journal suppl. entitled: Special Issue: 12th Asian Pacific Congress of Nephrology in conjunction with 4th Asian Forum of CKD Initiative 2010 & Korea-Japan HDF Forum 2010, June 5-8 2010, COEX, Seoul, Korea
Persistent Identifierhttp://hdl.handle.net/10722/185013
ISSN
2015 Impact Factor: 1.796
2015 SCImago Journal Rankings: 0.894

 

DC FieldValueLanguage
dc.contributor.authorYap, DYHen_US
dc.contributor.authorTang, CSOen_US
dc.contributor.authorMa, MKMen_US
dc.contributor.authorTse, KCen_US
dc.contributor.authorLam, MFen_US
dc.contributor.authorChan, TMen_US
dc.date.accessioned2013-07-15T10:23:51Z-
dc.date.available2013-07-15T10:23:51Z-
dc.date.issued2010en_US
dc.identifier.citationThe 12th Asian Pacific Congress of Nephrology (APCN 2010) in conjunction with 4th Asian Forum of CKD Initiative & Korea-Japan HDF Forum, Seoul, Korea, 5-8 June 2010. In Nephrology, 2010, v. 15 suppl. 3, p. 44, abstract no. FP05-10en_US
dc.identifier.issn1320-5358-
dc.identifier.urihttp://hdl.handle.net/10722/185013-
dc.descriptionOral Abstracts - Free Paper Session 05: no. FP05-10-
dc.descriptionThis free journal suppl. entitled: Special Issue: 12th Asian Pacific Congress of Nephrology in conjunction with 4th Asian Forum of CKD Initiative 2010 & Korea-Japan HDF Forum 2010, June 5-8 2010, COEX, Seoul, Korea-
dc.description.abstractINTRODUCTION: Improvements in immunosuppression and medical care have brought about changes in the clinical outcome of patients with lupus nephritis. We investigated the causes and the mortality risk factors of these patients in the present era. METHODS: This was a retrospective study of all patients followed in a lupus nephritis clinic since January 1971. The causes of death were identifi ed and the standardized mortality ratios (SMR) of potential risk factors were calculated with reference to the local general population. RESULTS: 287 Chinese patients were included. The follow-up was 5164.1 personyears (mean 18.0 ± 8.4 years). 230 patients (80.1%) had a history of Class III/IV ± V renal involvement. 27 patients (9.4%) died during follow-up. The 5-, 10-, and 20-year patient survival rates were 98.9%, 98.1% and 90.9% respectively, while corresponding renal survival rates were 98.6%, 96.6% and 85.3% respectively. The leading causes of death were infection (44.8%), malignancy (20.7%) and cardiovascular disease (17.2%). The overall SMR was 6.3, while that associated with renal involvement, endstage renal failure, malignancy, and cardiovascular disease was 6.4, 26.1, 13.0, and 11.4 respectively. CONCLUSION: Lupus nephritis is associated with a 6.4-fold increase in the risk of death compared with the general population, and lupus patients who develop endstage renal failure have a 26-fold excess in the risk of death.-
dc.languageengen_US
dc.publisherBlackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/NEP-
dc.relation.ispartofNephrologyen_US
dc.rightsNephrology. © Blackwell Publishing Asia.-
dc.titleCauses of death in patients with severe lupus nephritisen_US
dc.typeConference_Paperen_US
dc.identifier.emailYap, DYH: desmondy@hku.hken_US
dc.identifier.emailTang, CSO: csotang@hkucc.hku.hken_US
dc.identifier.emailLam, MF: feimflam@hku.hk-
dc.identifier.emailChan, TM: dtmchan@hku.hk-
dc.identifier.authorityYap, DYH=rp01607en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1440-1797.2010.01336.x-
dc.identifier.hkuros215683en_US
dc.identifier.volume15-
dc.identifier.issuesuppl. 3-
dc.identifier.spage44, abstract no. FP05-10-
dc.identifier.epage44, abstract no. FP05-10-
dc.publisher.placeAustralia-

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